Autofluorescence imaging endoscopy for screening of esophageal squamous mucosal high‐grade neoplasia: A phase II study

Abstract

The sensitivity of AFI for the detection of new squamous mucosal high-grade neoplasias, and its PPV, were both low. Based on these results, a randomized study to compare AFI with standard techniques is not justified.

Histological features responsible for brownish epithelium in squamous neoplasia of the esophagus by narrow band imaging

“…Narrow band imaging (NBI) is a non‐invasive optical technique that uses reflected light to visualize the organ surface . NBI can enhance the superficial structure and facilitate the detection of neoplastic lesions, and is regarded as the standard modality for screening of esophageal squamous neoplasias …”

Value of Autofluorescence in Video-Assisted Thoracoscopic Surgery in Pleural Diseases

“…Of these, 169 biopsies were from pleural thickenings (118 lesions) and 95 were from nodules (78 lesions). The mean number of biopsies per patient was 8 (range, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], and the mean numbers of nodules and pleural thickenings biopsied per patient were 6.7 and 6.5, respectively.…”

“…[1][2][3][4] AF illumination has been shown to improve diagnostic yield in various endoscopic procedures, including colonoscopy, esophagoscopy, and others. [5][6][7][8][9] Thoracic surgeons and chest specialists frequently use AF in bronchoscopy, where its efficacy has been well documented. [10][11][12] In bronchoscopy for the detection of premalignant and malignant lesions, the combination of AF and WL examination provides better diagnostic yield than WL examination alone.…”

Screening for Precancerous Lesions of Upper Gastrointestinal Tract: From the Endoscopists' Viewpoint

“…Recently, a phase-II study in Japan has shown unsatisfactory diagnostic power of AFI system in screening esophageal HGINs, with sensitivity of 71% (95% CI 55–87%) and PPV of 25% (95% CI 16–34%), especially for lesions ≦10 mm [63]. Therefore, AFI system plays a limited role in screening ESCC, especially for those with small size and depressed morphology.…”