Novelty detection is a task of machine learning that aims at detecting novel events without a prior knowledge. In particular, its techniques can be applied to detect unexpected signals from new phenomena at colliders. In this paper, we develop an analysis scheme that exploits the complementarity, originally studied in Ref. [1], between isolationbased and clustering-based novelty evaluators. This approach can significantly improve the performance and overall applicability of novelty detection at colliders, which we demonstrate using a variety of two dimensional Gaussian samples mimicking collider events. As a further proof of principle, we subsequently apply this scheme to the detection of two significantly different signals at the LHC featuring a t tγγ final state: t th, giving a narrow resonance in the diphoton mass spectrum, and gravity-mediated supersymmetry, which results in broad distributions at high transverse momentum. Compared to existing dedicated searches at the LHC, the sensitivities for both signals are found to be encouraging.