Autobronzants et bronzants artificiels

Martini, Mariele

doi:10.1016/j.annder.2017.03.021

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…The discovery of the chemical properties of DHA is what is called a serendipitous finding, as it was as interesting and stunning as it was unexpected. DHA was first used as a medicine to treat diabetic patients in the 1930s, but the scientists running the tests were surprised to observe a strong and unusual yellow staining of the patients’ gums [ 16 ]. A first artificial suntanning lotion was then released in California in 1945, but the coloration obtained was an unnatural orange color with strong stains on palms and other zones where the skin’s epidermis is thicker due to the lack of recommendations for an application method.…”

Section: An Overview Of Dha From Key Metabolite To Sunless Tanningmentioning

confidence: 99%

“…As mentioned above, DHA is primarily used as an ingredient in sunless tanning products, although minor uses are reported in various other fields ( Figure 4 ). It has been evaluated as a potential medicine for several diseases: for children with glycogen storage disease (diabetes) [ 14 , 17 , 23 , 24 , 25 , 26 ]; as a complementary photoprotector for patients suffering from various porphyric diseases, which are liver disorders leading notably to increased skin photosensitivity [ 27 , 28 ]; as an antifungal agent to cure dermatomycosis afflictions [ 29 , 30 ]; or as a symptomatic treatment for psoriasis [ 31 ] and vitiligo, a skin disorder resulting in the appearance of depigmented stains on the skin of affected patients [ 13 , 16 , 28 , 32 ]. DHA is also used as an important feedstock for the production of a range of industrially important chemicals, such as 1,2-propylene glycol, lactic acid, methotrexate, DL-serine and various surfactants [ 30 , 33 , 34 , 35 , 36 ].…”

Section: An Overview Of Dha From Key Metabolite To Sunless Tanningmentioning

confidence: 99%

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Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

et al. 2023

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1,3-dihydroxyacetone (DHA) is an underrated bio-based synthon, with a broad range of reactivities. It is produced for the revalorization of glycerol, a major side-product of the growing biodiesel industry. The overwhelming majority of DHA produced worldwide is intended for application as a self-tanning agent in cosmetic formulations. This review provides an overview of the discovery, physical and chemical properties of DHA, and of its industrial production routes from glycerol. Microbial fermentation is the only industrial-scaled route but advances in electrooxidation and aerobic oxidation are also reported. This review focuses on the plurality of reactivities of DHA to help chemists interested in bio-based building blocks see the potential of DHA for this application. The handling of DHA is delicate as it can undergo dimerization as well as isomerization reactions in aqueous solutions at room temperature. DHA can also be involved in further side-reactions, yielding original side-products, as well as compounds of interest. If this peculiar reactivity was harnessed, DHA could help address current sustainability challenges encountered in the synthesis of speciality polymers, ranging from biocompatible polymers to innovative polymers with cutting-edge properties and improved biodegradability.

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Section: An Overview Of Dha From Key Metabolite To Sunless Tanningmentioning

confidence: 99%

Section: An Overview Of Dha From Key Metabolite To Sunless Tanningmentioning

confidence: 99%

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

et al. 2023

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Exogenous exposure to dihydroxyacetone mimics high fructose induced oxidative stress and mitochondrial dysfunction

Mehta

Sonavane

Migaud

et al. 2021

Environ and Mol Mutagen

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Dihydroxyacetone (DHA) is a three‐carbon sugar that is the active ingredient in sunless tanning products and a by‐product of electronic cigarette (e‐cigarette) combustion. Increased use of sunless tanning products and e‐cigarettes has elevated exposures to DHA through inhalation and absorption. Studies have confirmed that DHA is rapidly absorbed into cells and can enter into metabolic pathways following phosphorylation to dihydroxyacetone phosphate (DHAP), a product of fructose metabolism. Recent reports have suggested metabolic imbalance and cellular stress results from DHA exposures. However, the impact of elevated exposure to DHA on human health is currently under‐investigated. We propose that exogenous exposures to DHA increase DHAP levels in cells and mimic fructose exposures to produce oxidative stress, mitochondrial dysfunction, and gene and protein expression changes. Here, we review cell line and animal model exposures to fructose to highlight similarities in the effects produced by exogenous exposures to DHA. Given the long‐term health consequences of fructose exposure, this review emphasizes the pressing need to further examine DHA exposures from sunless tanning products and e‐cigarettes.

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Dihydroxyacetone: An Updated Insight into an Important Bioproduct

et al. 2018

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Currently obtained from glycerol through microbial fermentation, the demand of 1,3‐dihydroxyacetone (DHA) has significantly grown during the course of the last decade, driven by the consumer passion for a tan and increasing awareness of UV photodamage to the skin caused by prolonged exposure to the sun. We provide an updated bioeconomy perspective into a valued bioproduct (DHA), whose supply and production from glycerol, we argue in this study, will rapidly expand and diversify, with important global health benefits.

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Autobronzants et bronzants artificiels

Cited by 5 publications

References 19 publications

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

Exogenous exposure to dihydroxyacetone mimics high fructose induced oxidative stress and mitochondrial dysfunction

Dihydroxyacetone: An Updated Insight into an Important Bioproduct

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