Autoantibodies to alfa-fodrin in patients with Hashimoto thyroiditis and Sjögren’s syndrome: possible markers for a common secretory disorder

Szántó, Antónia; Csípő, István; Horváth, Ildikó; Biró, Edit; Szodoray, Péter; Zeher, Margit

doi:10.1007/s00296-008-0582-z

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…Some studies declared that thyroid dysfunction including autoimmune thyroiditis affects both the quality and quantity of saliva [49] . Other studies declared that autoimmune changes that occur in endocrine glands such as thyroid may also occur in exocrine glands such as the salivary glands because the process of both is secretion [50] .…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the effect of experimentally induced hyperthyroidism and hypothyroidism on the parotid gland in adult male albino rats

Hashem

Saad

2019

Egyptian Journal of Histology

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Introduction:Thyroid dysfunctions are considered one of the most important endocrine disorders. Alterations in the level of thyroid hormones cause various subclinical or clinical manifestations. Salivary glands act as the biological media for food and the first line of defense for oral cavity and teeth. Any alterations in their integrity and activity can affect the patient's health. Aim: This study aimed to compare the possible histo-functional alterations that may occur in the parotid gland structure in an experimentally induced hyperthyroid and hypothyroid state. Materials and Methods: Twenty four adult male rats were divided into three equal groups. Group I: served as euthyroid.Group II (hyperthyroid group): rats received Eltroxine in a dose 600 μg/kg/day via an oral gavage feeding needle for three successive weeks. Group III (hypothyroid group): rats received Neomercazole in a dose of 1.35 mg /kg/day via an oral gavage feeding needle for three successive weeks. At the end of the experiment, all animals were weighed, blood samples were collected then all were sacrificed. The parotid glands were weighed and sampled for histopathological, Immunohistochemical and ultrastructural studies. Results: Examination of parotid sections of treated groups showed histopathological changes in the form of swollen serous acini, vacuolation, dilated duct, changes in secretory granules density, congested blood vessels and cellular infiltration. That is accompanied by significant changes in parotid gland weight, rat's body weight, mast cell number, Bcl-2 positive cells and serum amylase. Conclusion: It is recommended in cases of thyroid dysfunctions to monitor oral and dental health to follow salivary glands dysfunction.

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Section: Discussionmentioning

confidence: 99%

Comparative study of the effect of experimentally induced hyperthyroidism and hypothyroidism on the parotid gland in adult male albino rats

Hashem

Saad

2019

Egyptian Journal of Histology

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“…As Szanto A and his colleagues have suggested, autoimmune changes in endocrine glands such as thyroid, may also occur in exocrine glands such the salivary gland, because the process of both is secretion ( 13 ). These changes may occur in the salivary glands of HT patients too, and may cause salivary flow rate changes.…”

Section: Discussionmentioning

confidence: 99%

“…Sjögren´s syndrome is an autoimmune exocrinopathy often associated with Hashimoto´s Thyroiditis, and the probability of this association will increase through time ( 3 , 13 ). Therefore one of the most important considerations for a study on salivary changes in HT is ruling out Sjögren´s syndrome in these patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Xerostomia and salivary flow rate in Hashimoto’s Thyroiditis

Agha‐Hosseini

Shirzad²,

Moosavi³

2016

Med Oral

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BackgroundOne of the most common causes of hypothyroidism is Hashimoto´s Thyroiditis (HT). Early detection of dry mouth is critical in preserving and promoting systemic and oral health. In this study we have assessed, for the first time, salivary function and xerostomia in HT patients who have not been involved with Sjögren´s syndrome.Material and MethodsHT was diagnosed in 40 patients based on clinical findings and positive anti-thyroid peroxidase antibodies (anti-TPO). Controls, matched by sex, age and body mass index (BMI), and with no history of thyroid disease, were selected. A questionnaire was used for diagnosis of xerostomia. Saliva samples were taken between 8 a.m. and 9 a.m., and at least 2 hours after the last intake of food or drink. The flow rate was calculated in milliliters per minute.ResultsXerostomia was significantly higher in patients with HT. Unstimulated salivary flow rate was significantly lower in the HT group. Stimulated salivary flow rate was lower in HT group, but the difference was not significant.ConclusionsThe patients with HT experienced xerostomia, and their salivary flow rate was diminished. Spitting the saliva then assessing salivary flow rate based on milliliter per minute is non-invasive, fast, and simple for chair-side diagnosis of dry mouth. Autoimmune diseases can be accompanied by salivary gland dysfunction. This may be due to the effect of cytokines in the autoimmune process or because of thyroid hormone dysfunctions. Key words:Thyroid, salivary gland, xerostomia.

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“…Moreover, thyroid auto-antibodies such as TgAb have complement-fixing ability, if they are of an appropriate IgG a subclass, and complement-dependent antibody-mediated cytotoxicity leads to thyroid tissue damage [20]. Szanto et al [21] suggested that the thyroid endocrine gland and salivary exocrine glands may incur similar autoimmune changes, because both have secretory functions.…”

Section: Discussionmentioning

confidence: 99%

Salivary gland function in women with Hashimoto’s thyroiditis without xerostomia and the correlation with auto-thyroid antibodies

Xiaoan

Wei

et al. 2020

Nuklearmedizin

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Background Hashimoto’s thyroiditis (HT) may cause salivary dysfunction in patients resulting in xerostomia, but little is known about changes in salivary function in patients with no obvious dry mouth symptoms. In this study we assessed salivary function in women with HT, who had not experienced xerostomia and, for the first time, evaluated the effects of thyroid auto-antibodies on this function. Methods Sixty consecutive subjects were included, comprising 32 women (mean age, 36 ± 12 years) diagnosed with HT accompanied by differentiated thyroid cancer (DTC) in the study group (HT group), along with a control group (DTC group) of 28 women (mean age, 40 ± 12 years) diagnosed with DTC only. Salivary gland scintigraphy was used to assess salivary function with the semi-quantitative parameters of maximum absorption ratio and maximum secretion ratio, the decrease of which indicate impaired salivary function. Moreover, the HT and DTC groups were divided into four subgroups (Anti– HT, Anti+ HT, Anti– DTC, and Anti+ DTC), based on the presence of anti-thyroid peroxidase antibody (TPOAb) and anti-thyroglobulin antibody (TgAb). Finally, salivary gland semi-quantitative parameters were correlated with levels of thyroid-stimulating hormone (TSH), TGAb, and TPOAb in the HT and DTC groups. Results None of the semi-quantitative parameters examined in parotid or submandibular glands differed significantly between the HT and DTC groups. However, the maximum secretion ratio for the parotid and submandibular glands were significantly different in the subgroup comparison (p < 0.05). Furthermore, the TgAb, TPOAb, and TSH values correlated significantly with salivary excretive function (p ≤ 0.05). Conclusion Women with HT without xerostomia may not have salivary functional impairment during hypothyroidism. Serum thyroid autoantibody and TSH levels may mainly influence salivary excretive function but not uptake function.

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Autoantibodies to alfa-fodrin in patients with Hashimoto thyroiditis and Sjögren’s syndrome: possible markers for a common secretory disorder

Cited by 14 publications

References 19 publications

Comparative study of the effect of experimentally induced hyperthyroidism and hypothyroidism on the parotid gland in adult male albino rats

Comparative study of the effect of experimentally induced hyperthyroidism and hypothyroidism on the parotid gland in adult male albino rats

Evaluation of Xerostomia and salivary flow rate in Hashimoto’s Thyroiditis

Salivary gland function in women with Hashimoto’s thyroiditis without xerostomia and the correlation with auto-thyroid antibodies

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