Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele

Trevisani, Virgínia Fernandes Moça; Mattos, Kimble T.F.; Esteves, Renata F.; Olialves, Stella M.R.; Andrade, Luís Eduardo Coelho

doi:10.1076/ocii.9.4.231.3952

Cited by 9 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fifty percent to 67% of patients with acute anterior uveitis are HLA-B27 ϩ . [43][44][45] Recurrent episodes are frequent in HLA-B27-associated anterior uveitis, 46,47 and HLA-B27-associated anterior uveitis has been shown to develop at a younger age. 48 Our results were similar.…”

Section: Discussionmentioning

confidence: 99%

TNF−857T, a Genetic Risk Marker for Acute Anterior Uveitis

Kuo

Lympany

Menezo

et al. 2005

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

A significant difference in the frequency of TNF-857T allele was found in patients with IAU. There was a trend toward the development of inflammation-related complications in HLA-B27(+) patients with IAU who were carriers of TNFRSF1A-201T or TNFRSF1A-1135T alleles. Genetic variations in these proinflammatory mediators and their receptors appear to influence the susceptibility and severity of the inflammatory response within the eyes of patients during the development of IAU.

show abstract

Section: Discussionmentioning

confidence: 99%

TNF−857T, a Genetic Risk Marker for Acute Anterior Uveitis

Kuo

Lympany

Menezo

et al. 2005

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…The presence of specific autoantibodies against cornea, iris, crystalline, and some proteins of the posterior segment as antigen-S and rodopsin have been reported, specially in the context of idiopathic uveitis (31,32) . Our group has demonstrated the presence of specific antibodies against uveal extract in patients with non-HLA-B27 associated idiopathic uveitis (32) . However, the literature does not report on autoantibodies in idiopathic scleritis.…”

Section: Discussionmentioning

confidence: 99%

Sclera-Specific and non-sclera-specific autoantibodies in the serum of patients with non-infectious anterior scleritis

Aragaki¹,

Sousa²,

Trevisani³

et al. 2007

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

“…Sera from rats with EAU could not transfer disease [80], but antibodies to retinal autoantigens were detected in sera of human uveitis patients [81][82][83].…”

Section: Autoantibodiesmentioning

confidence: 99%

Uveitis in Horses, Rats and Man: What Do We Learn from Our Pets?

Deeg¹,

Wildner²,

Thurau

2011

CIR

View full text Add to dashboard Cite

The rat model of experimental autoimmune uveitis (EAU) is well established and has served for the development of new therapies in human uveitis. Uveitis in rats can be induced with a number of different autoantigens or peptides, while EAU in mice is only inducible with interphotoreceptor retinoid-binding protein (IRBP) or a single peptide of IRBP. For a long time the rat model was regarded as acute and monophasic, thus therapeutic interventions had to precede the induction of the disease by immunization or adoptive transfer of activated, autoantigen-specific T cells. Only recently spontaneous relapsing-remitting disease, induced with a peptide derived from IRBP, was detected in rats. Some years ago we have introduced the horse as a new animal model for uveitis: horses frequently have spontaneous uveitis (Equine Recurrent Uveitis, ERU) and will also develop the disease after immunization with retinal autoantigens. This offers the opportunity to directly compare spontaneous and induced diseases in the same species, which show high identities. Comparing different species, we found similarities between horses, rats, mice and humans with respect to the antigen-specificity of T cell responses, course of disease and histology. Proteomics of healthy and diseased equine eyes offered an insight of intraocular alterations during inflammation, which might be representative for uveitis in general.

show abstract

Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele

Abstract: Antibodies specific to iris antigens were equally frequent in both acute uveitis groups, whereas non-organ-specific autoantibodies, especially those to HeLa cell proteins, were far less frequent in B27(+)/AAU than in B27(-)/AAU patients.

Cited by 9 publications

References 38 publications

TNF−857T, a Genetic Risk Marker for Acute Anterior Uveitis

TNF−857T, a Genetic Risk Marker for Acute Anterior Uveitis

Sclera-Specific and non-sclera-specific autoantibodies in the serum of patients with non-infectious anterior scleritis

Uveitis in Horses, Rats and Man: What Do We Learn from Our Pets?

Contact Info

Product

Resources

About