Abstract:The rat model of experimental autoimmune uveitis (EAU) is well established and has served for the development of new therapies in human uveitis. Uveitis in rats can be induced with a number of different autoantigens or peptides, while EAU in mice is only inducible with interphotoreceptor retinoid-binding protein (IRBP) or a single peptide of IRBP. For a long time the rat model was regarded as acute and monophasic, thus therapeutic interventions had to precede the induction of the disease by immunization or ado… Show more
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