Autoantibodies against type XVII collagen C-terminal domain in a patient with bullous pemphigoid associated with psoriasis vulgaris

Abstract

effect of reproductive hormones on skin disorders have been somewhat hampered, however, by the fact that individual patient sensitivity varies widely and by a body of research that has employed diverse research parameters, such as dosage, testing sites, concentration, vehicle of irritant delivery, and method of assessment. Further research, with strict attention to standardizing experimental parameters and limiting compounding factors, will help to elucidate the biochemical basis for the observed effects of progesterone and oestrogen levels on skin health. Dermatologists should be aware that the menstrual cycle can affect the sensitivity of women to primary irritants and can affect their allergic response. References1 Itsekson A, Lazarov A, Cordoba M et al. Premenstrual syndrome and associated skin diseases related to hypersensitivity to female sex hormones. J Reprod Med 2004; 49:195-9. 2 Kirmaz C, Yuksel H, Mete N et al. Is the menstrual cycle affecting the skin prick test reactivity? Asian Pac J Allergy Immunol 2004; 22:197-203. 3 Agarwal S, Shukla HS, Verma M et al. Investigation of lymphocyte subpopulations and hypersensitivity skin tests during the menstrual cycle and pregnancy. Ann Chir Gynaecol 1982; 71:117-21. 4 Bonamonte D, Foti C, Antelmi AR et al. Nickel contact allergy and menstrual cycle. Contact Dermatitis 2005; 52:309-13. 5 Kiriyama K, Sugiura H, Uehara M. Premenstrual deterioration of skin symptoms in female patients with atopic dermatitis. Dermatology 2003; 206:110-12. 6 Agner T. Noninvasive measuring methods for the investigation of irritant patch test reactions. a study of patients with hand eczema, atopic dermatitis and controls. Acta Derm Venereol (Stockh) 1992; 173 (Suppl.):1-26. 7 Tamer E, Ikizoglu G, Toy GG et al. Comparison of nickel patch test reactivity in phases of the menstrual cycle. Int J Dermatol 2003; 42:455-8. 8 Rohold AE, Halkier-Sørensen L, Andersen KE et al. Nickel patch test reactivity and the menstrual cycle. Acta Derm Venereol (Stockh) 1994; 74:383-5. 9 Kemmett D, Tidman MJ. The influence of the menstrual cycle and pregnancy on atopic dermatitis. Br J Dermatol 1991; 125:59-61.

Psoriasis: an evidence-based update. Report of the 9th Evidenced Based Update Meeting, 12 May 2011, Loughborough, U.K.

“…However, the deficiencies in the evidence were clear to see: many trials are still relatively short with clinical and methodological heterogeneity, lack of effective treatments for nail psoriasis and PPP, a need for long‐term safety trials for various agents including potent and superpotent topical corticosteroids, as well as combination of biologics with phototherapy or other systemic treatments, and routine assessment of quality of life in trials with topical treatments. Numerous publications are currently produced in this field and it is hoped that with the aid of the Evidence Based Update Meeting and similar steering meetings the above deficiencies might be adequately addressed in due course 72–163 . The feedback from the delegates was very positive: 60% said the meeting was extremely useful and 39% useful.…”