Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells

Bigler, Cornelia; Schaller, Monica; Perahud, Iryna; Trendelenburg, Marten

doi:10.1016/j.molimm.2008.08.068

Cited by 25 publications

(28 citation statements)

References 4 publications

(5 reference statements)

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“…Regarding anti-C1q Ab, another mechanism is proposed that involves deposition in the glomeruli together with C1q to induce renal inflammation that occurs only in the context of glomerular immune complex disease [30]. Recent studies also suggest that anti-C1q Ab target C1q bound on early apoptotic cells during LN flares [31,32].…”

Section: Discussionmentioning

confidence: 99%

Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis

Séret¹,

Cañas²,

Costanzo³

et al. 2015

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 99%

Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis

Séret¹,

Cañas²,

Costanzo³

et al. 2015

Journal of Autoimmunity

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“…C1q is important in the clearance of immune complexes and self antigens generated during cell death [30,31], and a recent study suggests that the real target might be apoptotic cells [32]. Defective clearance of apoptotic cells, which may become antigenic, is an important hypothesis about the pathogenesis of SLE [33], and primary (hereditary) deWciency of C1q is a known risk factor for the development of the disease [34,35].…”

Section: Discussionmentioning

confidence: 99%

Nonrenal and renal activity of systemic lupus erythematosus: a comparison of two anti-C1q and five anti-dsDNA assays and complement C3 and C4

2011

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Associations of different assays for antibodies to C1q (anti-C1q) and to dsDNA (anti-dsDNA) and of complements C3 and C4 with disease activity in patients with systemic lupus erythematosus (SLE) were studied. The clinical manifestations of 223 SLE patients were recorded, and the disease activity was assessed by the SLEDAI score. Anti-C1q were determined by two enzyme-linked immunosorbent assays (ELISA) and anti-dsDNA by a radioimmunoassay (RIA), a Crithidia immunofluorescence (IF) assay and three ELISA assays using human telomere DNA, plasmid DNA circles, or calf thymus DNA as antigens, respectively. Complement C3 and C4 were determined by nephelometry. Control sera were obtained from 98 blood donors. In patients with SLE, the prevalence of anti-C1q was 17-18% and that of anti-dsDNA was 36-69%. Anti-C1q, anti-dsDNA, and complement C3 and C4 correlated well with the overall activity of SLE (r = 0.323-0.351, 0.353-0.566, and -0.372-0.444, respectively; P < 0.001). Sensitivity, specificity, positive predictive value, and negative predictive value for active lupus nephritis among SLE patients were 40-44, 92, 29, and 91-92% for anti-C1q and 48-68, 29-66, 11-16, and 86-91% for anti-dsDNA, respectively. Patients with active nephritis had higher levels of anti-C1q and lower levels of C3 and C4 than patients with inactive nephritis (P = 0.003-0.018). The corresponding associations of anti-dsDNA were somewhat weaker (P = 0.023-0.198). Hematological parameters reflecting disease activity correlated clearly better with anti-dsDNA and complement C3 and C4 than with anti-C1q. Anti-C1q is inferior to anti-dsDNA as a diagnostic test in SLE and in the evaluation of overall clinical activity of the disease. Anti-C1q together with complement C3 and C4 may offer useful additional information to monitor lupus nephritis activity. There are no practical differences between different assays for anti-C1q and anti-dsDNA.

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“…Rosen and co-workers suggested that a considerable number of lupus autoantigens were clustered within apoptotic blebs [49,50]. This condition is further compounded by the presence of anti-C1q autoantibodies detected in the sera of a number of patients suffering from SLE [51][52][53][54][55]. The CRT binds to the CD91 and C1q, which is known to bind to the CRT through its collagenous "tail", forms a complex with CRT/CD91.…”

Section: Clearance Of Apoptotic and Necrotic Cells Via C1qmentioning

confidence: 99%

The non-classical functions of the classical complement pathway recognition subcomponent C1q

et al. 2010

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Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells

Cited by 25 publications

References 4 publications

Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis

Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis

Nonrenal and renal activity of systemic lupus erythematosus: a comparison of two anti-C1q and five anti-dsDNA assays and complement C3 and C4

The non-classical functions of the classical complement pathway recognition subcomponent C1q

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