Anti-alpha-actinin antibodies are part of the anti-cell membrane antibody spectrum that characterize patients with lupus nephritis

The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

“…68 Another glomerular antigen, α-actinin, had been described as a major target for cross-reactive anti-dsDNA Ab in murine lupus models and human disease. 62,69–76 Most recently, Seret et al demonstrated that sera from LN patients distinguish themselves from those with other autoimmune diseases by circulating anti-cell-membrane Ab that predominantly target α-actinin. 76 Interestingly, the binding of anti-cell-membrane Ab was not affected by pre-treatment with DN ase I.…”

Pathogenesis of proliferative lupus nephritis from a historical and personal perspective

“…In addition it was shown that the anti-α-enolase and anti-annexin Abs did not cross react with DNA. Recently circulating Abs to multiple membrane components were preferentially demonstrated in patients with LN (18), suggesting that these Ab may participate in the initiation of LN. In summary, multiple studies suggest that auto-Ab of diverse specificity are capable of initiating LN.…”

“…The above cited studies (16–18) regarding auto-Ab that may initiate LN provide useful information regarding the distribution of IgG subclasses of these Ab. It has been emphasized that anti-cell membrane Ab such as anti-α enolase, anti-laminin Ab and anti-C1q auto-Abs are predominantly IgG2 and anti-dsDNA Ab are IgG2 and IgG3.…”

Anti-DNA and Anti-Nucleosome Antibodies: An Update

“…alpha-actinin, annexin A1), podocyte targets (e.g. α-enolase) and anti-anti-C1q [21][22][23][24]; (ii) psychiatric and/or neurological involvement through cross-reactivity with anti-ribosomal P Ab and anti-cardiolipin Ab [25,26]; and (iii) infections by inhibiting plasmodial growth [27] or by cross reacting with the Herp protein synthesized by Escherichia Coli [28] and the EBNA-1 protein from the Epstein Barr virus [29].…”