Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation

Akizuki, Kazutoshi; Kinumi, Tomoya; Ono, Aoi; Senga, Yukako; Osawa, Jin; Shigeri, Yasushi; Ishida, Atsuhiko; Kameshita, Isamu; Sueyoshi, Noriyuki

doi:10.1016/j.abb.2019.05.004

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…EphA3 and SPATA9 were lower in some tumors tissue and served as tumor-suppressors [41]. Many studies have confirmed that MYO7A, Ninj1, IGF2R, METTL7B, and CAMK1 increased expression is related to tumors [42][43][44][45]. However, the correlation of these genes with RhoBTB3 has not been verified in molecular biology experiment.…”

Section: Discussionmentioning

confidence: 98%

High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia

Yang¹,

Liu²,

Peng³

et al. 2021

J. Cancer

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Background:The expression patterns and prognostic significance of the Rho family GTPases in acute myeloid leukemia have not been systematically studied yet. Methods: In our study, we analyzed the expression patterns of 21 Rho family GTPases gene members in AML patients based on GEPIA database. 10 gene members with significant differential expression in AML tissue and healthy tissue were selected for subsequent research. Survival curve analysis in TCGA and GEO dataset preliminary showed that RhoBTB3 is related with the prognosis of non-M3 AML patients. The differential expression of RhoBTB3 on AML bone marrow and normal bone marrow was verified by RT-qPCR. We performed Kaplan-Meier survival analysis and Multivariate Cox analysis to assess the prognostic value of RhoBTB3 in non-M3 AML patients with different treatment regimens. Gene functional enrichment analysis of RhoBTB3 was performed using GO, KEGG and PPI network. Results: The AML patients from TCGA database were partitioned into 2 groups based on different treatment regimens: chemotherapy group and allo-HSCT group. In chemotherapy group, patients with higher expression level of RhoBTB3 showed relatively longer OS and EFS, multivariate Cox analysis revealed high RhoBTB3 mRNA expression as an independent favorable prognostic factor. However, in allo-HSCT group, no significant difference of OS and EFS were found between RhoBTB3 high and low subgroups. Meanwhile, allo-HSCT could circumvent the unfavorable prognosis that was associated with downregulation of RhoBTB3. Functional enrichment analysis showed the association of RhoBTB3 expression with several fundamental physiological components and pathways, including extracellular matrix components, extracellular structure organization, and cytokine-cytokine receptor interaction. Conclusions: Our study identified RhoBTB3 as a prognostic marker and may aid in the selection of the appropriate treatment options between chemotherapy and allo-HCST in non-M3 AML patients. Further researches are necessary to clarify the involvement of RhoBTB3 in the pathogenesis of AML.

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Section: Discussionmentioning

confidence: 98%

High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia

Yang¹,

Liu²,

Peng³

et al. 2021

J. Cancer

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“…In addition, some studies have found that GGT5 is a poor prognostic factor for gastric cancer [30]. CAMK1D is a member of the Ca2+/CaMdependent kinase CaMKI family and is widely expressed in human tissues [31]. CAMK1D has been con rmed to be involved in developmental differentiation and disease processes in various cells and tissues.…”

Section: Discussionmentioning

confidence: 99%

Discovery of N6-methyladenosine modification regulators and their related mRNAs in endometriosis

Ren¹,

He²,

Wang³

et al. 2023

Preprint

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Background N6-methyladenosine(m6A) modification regulates the processes of RNA splicing, subcellular localization, translation and stability by changing the RNA structure and the interaction between RNA and RNA-binding proteins to ensure the timely and accurate expression of genes. In this study, we investigated m6A regulators and m6A-related genes and for the first time explored effective prevention and treatment targets in endometriosis (EM). Methods By incorporating the Gene Expression Omnibus (GEO) database, biological information analysis technologies, and validation of other databases, aberrant m6A-methylated genes and m6A-related genes were uncovered, as well as efficient therapeutic drugs. Results METTL3, RMB15B, FTO, YTHDF1, and YTHDF2 might be vital m6A regulators, and GGT5 and CAMK1D may be essential m6A-related genes of EM. A few crucial small-molecule agents supply new views for the treatment of EM. Conclusion These results demonstrated novel insights into m6A methylation of EM and revealed potential biomarkers and precision medicine strategies for EM.

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Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection

Acharya,

Singh,

Gupta

et al. 2024

Cellular Signalling

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Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation

Cited by 4 publications

References 30 publications

High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia

High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia

Discovery of N6-methyladenosine modification regulators and their related mRNAs in endometriosis

Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection

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