Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection

Acharya, Manish; Singh, Nicky; Gupta, Gaurav; Tambuwala, Murtaza M.; Aljabali, Alaa A.A.; Chellappan, Dinesh Kumar; Dua, Kamal; Goyal, Rohit

doi:10.1016/j.cellsig.2024.111043

Cited by 3 publications

(3 citation statements)

References 161 publications

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“…Specifically, our investigation into calbindin-D28k expressing neurons unveils a novel association: That is a minority of these neurons express NPY, featuring enlarged soma with shorter neurite extension, correlated with decreased excitability and a reduced N-type calcium current density. Calbindin-D28K, a calcium-binding protein regulated by vitamin D [1, 2, 7], has served as a marker to distinguish between neuronal subtypes within both the central and peripheral nervous system [10, 11, 15, 28]. However, the cardiac population of calbindin neurons has been relatively understudied, with only one investigation conducted in rats [25] and a prior examination from our team identifying this population in mice [21].…”

Section: Discussionmentioning

confidence: 99%

“…This remodeling mirrors the characteristics observed in cardiac calbindin neurons, prompting an important inquiry into whether changes in calbindin expression could underlie these pathologies. Furthermore, calbindin D28K expression is known to be dependent on vitamin D3 [1, 2, 7]. Since vitamin D deficiency has been associated with type 2 diabetes, heart failure, and atrial fibrillation [9], investigating calbindin expression in cardiac neurons within this context holds considerable interest.…”

Section: Discussionmentioning

confidence: 99%

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Distinct Excitability Properties of Cardiac Calbindin Neurons: Identifying a Unique Neuronal Population

Lizot,

Bescond,

De Koninck

et al. 2024

Preprint

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The intrinsic cardiac nervous system is a complex system that plays a critical role in the regulation of cardiac physiological parameters and has been shown to contribute to cardiac arrhythmias. To date, several types of neurons with distinct neurochemical and electrophysiological phenotypes have been identified. However, no study has correlated the neurochemical phenotype to a specific electrophysiological behavior. Calbindin-D28k, a calcium binding protein, is expressed in numerous cardiac neurons. Given that changes in neuronal excitability have been associated with arrhythmia susceptibility and that calbindin expression has been associated with modulations of neuronal excitability, our objective is to assess whether the cardiac calbindin neuronal population has specific properties that could be involved in cardiac modulation and arrhythmias. By using a Cre-Lox mouse model to specifically target calbindin neurons with a fluorescent reporter, we characterized the neurochemical and the electrophysiological phenotype of this cardiac neuronal population. Calbindin neurons exhibit a specific neurochemical profile and a larger soma with shorter neurite length compared to other neurons. This was combined with a distinct electrophysiological signature characterized by a lower excitability with a predominantly phasic profile associated to a lower N-type calcium current density. These properties resemble to the cardiac neuronal remodeling observed in pathologies such as type II diabetes and heart failure. Therefore, we believe that this specific neuronal population deserves investigations in the context of these pathologies.Statements and DeclarationsThe authors have no competing interests to declare that are relevant to the content of this article.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distinct Excitability Properties of Cardiac Calbindin Neurons: Identifying a Unique Neuronal Population

Lizot,

Bescond,

De Koninck

et al. 2024

Preprint

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“…Last but not least, all these calbindins may be correlated with the pathophysiology of lung cancer through the inflammatory processes. This is based on the observation that calcium modulation was proven to be important in many diseases that exhibit inflammation, such as Alzheimer’s and diabetes, or in inflammation-associated bone resorption, which was correlated with calcium presence, even if the effects of an increased/decreased calcium level led to different responses for different inflammatory processes [ 50 , 52 , 62 ].…”

Section: The Role Of Vitamin D and Vitamin D Receptor In Immunity And...mentioning

confidence: 99%

Exploring the Role of Vitamin D, Vitamin D-Dependent Proteins, and Vitamin D Receptor Gene Variation in Lung Cancer Risk

Ciocarlie,

Motofelea,

Motofelea

et al. 2024

IJMS

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Lung cancer has an unfavorable prognosis with a rate of low overall survival, caused by the difficulty of diagnosis in the early stages and resistance to therapy. In recent years, there have been new therapies that use specific molecular targets and are effective in increasing the survival chances of advanced cancer. Therefore, it is necessary to find more specific biomarkers that can identify early changes in carcinogenesis and allow the earliest possible treatment. Vitamin D (VD) plays an important role in immunity and carcinogenesis. Furthermore, the vitamin D receptor (VDR) regulates the expression of various genes involved in the physiological functions of the human organism. The genes encoding the VDR are extremely polymorphic and vary greatly between human populations. To date, there are significant associations between VDR polymorphism and several types of cancer, but the data on the involvement of VDR polymorphism in lung cancer are still conflicting. Therefore, in this review, our aim was to investigate the relationship between VDR single-nucleotide polymorphisms in humans and the degree of risk for developing lung cancer. The studies showcased different gene polymorphisms to be associated with an increased risk of lung cancer: TaqI, ApaI, BsmI, FokI, and Cdx2. In addition, there is a strong positive correlation between VD deficiency and lung cancer development. Still, due to a lack of awareness, the assessment of VD status and VDR polymorphism is rarely considered for the prediction of lung cancer evolution and their clinical applicability, despite the fact that studies have shown the highest risk for lung cancer given by TaqI gene polymorphisms and that VDR polymorphisms are associated with more aggressive cancer evolution.

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Investigating Deep Learning for Early Detection and Decision-Making in Alzheimer’s Disease: A Comprehensive Review

Hcini,

Jdey,

Dhahri

2024

Neural Process Lett

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Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people worldwide, making early detection essential for effective intervention. This review paper provides a comprehensive analysis of the use of deep learning techniques, specifically convolutional neural networks (CNN) and vision transformers (ViT), for the classification of AD using brain imaging data. While previous reviews have covered similar topics, this paper offers a unique perspective by providing a detailed comparison of CNN and ViT for AD classification, highlighting the strengths and limitations of each approach. Additionally, the review presents an updated and thorough analysis of the most recent studies in the field, including the latest advancements in CNN and ViT architectures, training methods, and performance evaluation metrics. Furthermore, the paper discusses the ethical considerations and challenges associated with the use of deep learning models for AD classification, such as the need for interpretability and the potential for bias. By addressing these issues, this review aims to provide valuable insights for future research and clinical applications, ultimately advancing the field of AD classification using deep learning techniques.

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Vitamin D, Calbindin, and calcium signaling: Unraveling the Alzheimer's connection

Cited by 3 publications

References 161 publications

Distinct Excitability Properties of Cardiac Calbindin Neurons: Identifying a Unique Neuronal Population

Distinct Excitability Properties of Cardiac Calbindin Neurons: Identifying a Unique Neuronal Population

Exploring the Role of Vitamin D, Vitamin D-Dependent Proteins, and Vitamin D Receptor Gene Variation in Lung Cancer Risk

Investigating Deep Learning for Early Detection and Decision-Making in Alzheimer’s Disease: A Comprehensive Review

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