‘Autistic psychopathy’ in childhood

Asperger, Hans

doi:10.1017/cbo9780511526770.002

Cited by 529 publications

(367 citation statements)

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“…19 Unaware of Kanner 's description of early infantile autism published just the year before, Asperger called the condition he described "autistic psychopathy", indicating a stable personality disorder marked by social isolation. Despite preserved intellectual skills, the children showed marked paucity of nonverbal communication involving both gestures and affective tone of voice, poor empathy and a tendency to intellectualize emotions, an inclination to engage in long winded, one-sided, and sometimes incoherent speech, rather formalistic speech (he called them "little professors"), all-absorbing interests involving unusual topics which dominated their conversation, and motoric clumsiness.…”

Section: History and Nosologymentioning

confidence: 99%

Autismo e síndrome de Asperger: uma visão geral

Klin

2006

Rev. Bras. Psiquiatr.

298

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Autismo e síndrome de Asperger são entidades diagnósticas em uma família de transtornos de neurodesenvolvimento nos quais ocorre uma ruptura nos processos fundamentais de socialização, comunicação e aprendizado. Esses transtornos são coletivamente conhecidos como transtornos invasivos de desenvolvimento. Esse grupo de condições está entre os transtornos de desenvolvimento mais comuns, afetando aproximadamente 1 em cada 200 indivíduos. Eles estão também entre os com maior carga genética entre os transtornos de desenvolvimento, com riscos de recorrência entre familiares da ordem de 2 a 15% se for adotada uma definição mais ampla de critério diagnóstico. Seu início precoce, perfil sintomático e cronicidade envolvem mecanismos biológicos fundamentais relacionados à adaptação social. Avanços em sua compreensão estão conduzindo a uma nova perspectiva da neurociência ao estudar os processos típicos de socialização e das interrupções específicas deles advindas. Esses processos podem levar à emergência de fenótipos altamente heterogêneos associados ao autismo, o paradigmático transtorno invasivo de desenvolvimento e suas variantes. Esta revisão foca o histórico, a nosologia e as características clínicas e associadas aos dois transtornos invasivos de desenvolvimento mais conhecidos - o autismo e a síndrome de Asperger.

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Section: History and Nosologymentioning

confidence: 99%

Autismo e síndrome de Asperger: uma visão geral

Klin

2006

Rev. Bras. Psiquiatr.

298

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“…Likewise, others have hypothesized about the nature of the relationship between Asperger's and schizoid or schizotypal characteristics in children (Wolff, 2000) and adults (Tantum, 1991). It should be noted that, over the years, children who displayed odd-eccentric characteristics have been variously classified using terms including "schizoid psychopathy of childhood" (Ssucharewa, 1926), "autistic psychopathy of childhood" (Asperger, 1944;translated by Frith, 1991), "schizoid personality disorder" (Wolff, 2000), and "schizotypal personality disorder" (Nagy and Szatmari, 1986). It is unclear how these taxonomic variations related to diagnosis of these children when they reached adulthood.…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Asperger’s Characteristics and Schizotypal Personality Traits in a Non-clinical Adult Sample

Hurst

Nelson‐Gray

Mitchell

et al. 2006

J Autism Dev Disord

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“…1,2 The syndrome remained widely unrecognised until the 1980s, when the general knowledge of this condition began to expand. 3 Detailed cross-sectional studies have defined the disease to belong to the autism spectrum disorders, [4][5][6] and currently the diagnostic definitions are outlined in the International Classification of Diseases (ICD-10) 7 and in the 4th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide scan for loci of Asperger syndrome

et al. 2004

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Asperger syndrome (AS), characterised by inadequate social interaction, lack of empathy and a dependence of routines and rituals, is classified as belonging to the autism spectrum disorders (DSM-IV and ICD-10). Although the prevalence of AS has been estimated to range from 0.3 up to 48.4 per 10 000, the phenotype still remains relatively unrecognised by clinicians. Several reports, including the original description by Hans Asperger (1944), have suggested that AS has a strong genetic component. Here, we have performed a genome-wide scan on Finnish families ascertained for AS with a strictly defined phenotype. In the initial scan, Z max 41.5 was observed on nine chromosomal regions, 1q21-22, 3p14-24, 3q25-27, 4p14, 4q32, 6p25, 6q16, 13q31-33 and 18p11. In the fine mapping stage, the highest two-point LOD scores were observed on chromosomes 1q21-22 (D1S484, Z max dom ¼3.58), 3p14-24 (D3S2432, Z max dom ¼2.50) and 13q31-33 (D13S793, Z max dom ¼1.59). The loci on 1q21-22 and 3p14-24 overlap with previously published autism susceptibility loci, and the loci on 1q21-22 and 13q31-33 overlap with the reported schizophrenia susceptibility loci. The present study is the first genome-wide screen in AS and therefore replication data sets are needed to evaluate further the significance of the AS-loci identified here.

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‘Autistic psychopathy’ in childhood

Cited by 529 publications

References 0 publications

Autismo e síndrome de Asperger: uma visão geral

Autismo e síndrome de Asperger: uma visão geral

The Relationship of Asperger’s Characteristics and Schizotypal Personality Traits in a Non-clinical Adult Sample

Genome-wide scan for loci of Asperger syndrome

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