Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations

García-Oscos, Francisco; Koch, Therese; Pancholi, Harshida; Trusel, Massimo; Daliparthi, Vamsi; Park, Seon-Hye E.; Ayhan, Fatma; Alam, Danyal; Holdway, Jennifer E.; Konopka, Genevieve; Roberts, Todd F.

doi:10.1126/sciadv.abd2827

Cited by 19 publications

(27 citation statements)

References 63 publications

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“…For example, one study reported that lesions within NCM did not significantly interfere with the accurate sensorimotor development of song (22,80). In addition, a number of experiments have suggested that tutoring-dependent plasticity within the sensorimotor nucleus HVC (used as a proper name) is critical for the sensory learning of song (81)(82)(83)(84)(85). In this respect, it is possible that NE infusions into NCM allow for greater tutoring-dependent plasticity within sensorimotor circuitry.…”

Section: Discussionmentioning

confidence: 99%

Norepinephrine in the avian auditory cortex enhances developmental song learning

Sakata

2021

Journal of Neurophysiology

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Sensory learning during critical periods in development has lasting effects on behavior. Neuromodulators like dopamine and norepinephrine (NE) have been implicated in various forms of sensory learning, but little is known about their contribution to sensory learning during critical periods. Songbirds like the zebra finch communicate with each other using vocal signals (e.g., songs) that are learned during a critical period in development, and the first crucial step in song learning is memorizing the sound of an adult conspecific's (tutor's) song. Here we analyzed the extent to which NE modulates the auditory learning of a tutor's song and the fidelity of song imitation. Specifically, we paired infusions of NE or vehicle into the caudomedial nidopallium (NCM) with brief epochs of song tutoring. We analyzed the effect of NE in juvenile zebra finches that had or had not previously been exposed to song. Regardless of previous exposure to song, juveniles that received NE infusions into NCM during song tutoring produced songs that were more acoustically similar to the tutor song and that incorporated more elements of the tutor song than juveniles with control infusions. These data support the notion that NE can regulate the formation of sensory memories that shape the development of vocal behaviors that are used throughout an organism's life.

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Section: Discussionmentioning

confidence: 99%

Norepinephrine in the avian auditory cortex enhances developmental song learning

Sakata

2021

Journal of Neurophysiology

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“…RELN (reelin) [133][134][135]. FOXP1 (forkhead box protein P1) [136][137][138][139]. SYNGAP1 (synaptic Ras GTPase-activating protein 1) [140,141].…”

Section: Genes and Geneticsmentioning

confidence: 99%

Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

et al. 2021

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Autism spectrum disorder (ASD) and Alzheimer’s disease (AD) are neurodevelopmental and neurodegenerative disorders affecting two opposite ends of life span, i.e., childhood and old age. Both disorders pose a cumulative threat to human health, with the rate of incidences increasing considerably worldwide. In the context of recent developments, we aimed to review correlated symptoms and genetics, and overlapping aspects in the mechanisms of the pathogenesis of ASD and AD. Dementia, insomnia, and weak neuromuscular interaction, as well as communicative and cognitive impairments, are shared symptoms. A number of genes and proteins linked with both disorders have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, and FMR1. Theories about the role of neuron development, processing, connectivity, and levels of neurotransmitters in both disorders have been discussed. Based on the recent literature, the roles of FMRP (Fragile X mental retardation protein), hnRNPC (heterogeneous ribonucleoprotein-C), IRP (Iron regulatory proteins), miRNAs (MicroRNAs), and α-, β0, and γ-secretases in the posttranscriptional regulation of cellular synthesis and processing of APP (amyloid-β precursor protein) have been elaborated to describe the parallel and overlapping routes and mechanisms of ASD and AD pathogenesis. However, the interactive role of genetic and environmental factors, oxidative and metal ion stress, mutations in the associated genes, and alterations in the related cellular pathways in the development of ASD and AD needs further investigation.

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“…Moreover, recent genomic research has identified potential genetic substrates for the evolution and regulation of vocal communication ( Warren et al, 2010 ). Furthermore, expression of the ASD gene FOXP1 is reported to cause severe impairment in speech/language learning and affect the cultural transmission of bird songs between adult and juvenile zebra finches ( Garcia-Oscos et al, 2021 ).…”

Section: Common Animals Used In Asd Studymentioning

confidence: 99%

Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Zhu

et al. 2021

Zoological Research

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Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental factors solely or in combination cause ASD. However, the underlying pathogenic mechanism is unclear due to its highly heterogeneous nature. To better understand the pathogenesis of ASD, various animal models have been generated, which can be generally divided into genetic, environment-induced, and idiopathic animal models. In this review, we summarize the common animals used for ASD study and then discuss the applications, clinical insights, as well as challenges and prospects of current ASD animal models.

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Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations

Cited by 19 publications

References 63 publications

Norepinephrine in the avian auditory cortex enhances developmental song learning

Norepinephrine in the avian auditory cortex enhances developmental song learning

Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

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