The hot intra-cluster medium (ICM) permeating galaxy clusters and groups is not pristine, as it has been continuously enriched by metals synthesised in Type Ia (SNIa) and core-collapse (SNcc) supernovae since the major epoch of star formation (z 2-3). The cluster/group enrichment history and mechanisms responsible for releasing and mixing the metals can be probed via the radial distribution of SNIa and SNcc products within the ICM. In this paper, we use deep XMM-Newton/EPIC observations from a sample of 44 nearby cool-core galaxy clusters, groups, and ellipticals (CHEERS) to constrain the average radial O, Mg, Si, S, Ar, Ca, Fe, and Ni abundance profiles. The radial distributions of all these elements, averaged over a large sample for the first time, represent the best constrained profiles available currently. Specific attention is devoted to a proper modelling of the EPIC spectral components, and to other systematic uncertainties that may affect our results. We find an overall decrease of the Fe abundance with radius out to ∼0.9r 500 and ∼0.6r 500 for clusters and groups, respectively, in good agreement with predictions from the most recent hydrodynamical simulations. The average radial profiles of all the other elements (X) are also centrally peaked and, when rescaled to their average central X/Fe ratios, follow well the Fe profile out to at least ∼0.5r 500 . As predicted by recent simulations, we find that the relative contribution of SNIa (SNcc) to the total ICM enrichment is consistent with being uniform at all radii, both for clusters and groups using two sets of SNIa and SNcc yield models that reproduce the X/Fe abundance pattern in the core well. In addition to implying that the central metal peak is balanced between SNIa and SNcc, our results suggest that the enriching SNIa and SNcc products must share the same origin and that the delay between the bulk of the SNIa and SNcc explosions must be shorter than the timescale necessary to diffuse out the metals. Finally, we report an apparent abundance drop in the very core of 14 systems (∼32% of the sample). Possible origins of these drops are discussed.

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High-resolution X-ray spectroscopy with Hitomi was expected to resolve the origin of the faint unidentified » E 3.5 keV emission line reported in several low-resolution studies of various massive systems, such as galaxies and clusters, including the Perseus cluster. We have analyzed the Hitomi first-light observation of the Perseus cluster. The emission line expected for Perseus based on the XMM-Newton signal from the large cluster sample under the dark matter decay scenario is too faint to be detectable in the Hitomi data. However, the previously reported 3.5 keV flux from Perseus was anomalously high compared to the sample-based prediction. We find no unidentified line at the reported high flux level. Taking into account the XMM measurement uncertainties for this region, the inconsistency with Hitomi is at a 99% significance for a broad dark matter line and at 99.7% for a narrow line from the gas. We do not find anomalously high fluxes of the nearby faint K line or the Ar satellite line that were proposed as explanations for the earlier 3.5 keV detections. We do find a hint of a broad excess near the energies of high-n transitions of S XVI (  E 3.44 keV rest-frame)-a possible signature of charge exchange in the molecular nebula and another proposed explanation for the unidentified line. While its energy is consistent with XMM pn detections, it is unlikely to explain the MOS signal. A confirmation of this interesting feature has to wait for a more sensitive observation with a future calorimeter experiment.

Motivated by recent claims of a compelling ∼3.5 keV emission line from nearby galaxies and galaxy clusters, we investigate a novel plasma model incorporating a charge exchange component obtained from theoretical scattering calculations. Fitting this kind of component with a standard thermal model yields positive residuals around 3.5 keV, produced mostly by S xvi transitions from principal quantum numbers n ≥ 9 to the ground. Such high-n states can only be populated by the charge exchange process. In this scenario, the observed 3.5 keV line flux in clusters can be naturally explained by an interaction in an effective volume of ∼1 kpc 3 between a ∼3 keV temperature plasma and cold dense clouds moving at a few hundred keV −1 . The S xvi lines at ∼3.5 keV also provide a unique diagnostic of the charge exchange phenomenon in hot cosmic plasmas.

High-resolution spectroscopy of the core of the Perseus Cluster of galaxies, using the Hitomi satellite above 2 keV and the XMM-Newton Reflection Grating Spectrometer at lower energies, provides reliable constraints on the abundances of O, Ne, Mg, Si, S, Ar, Ca, Cr, Mn, Fe, and Ni. Accounting for all known systematic uncertainties, the Ar/Fe, Ca/Fe, and Ni/Fe ratios are determined with a remarkable precision of less than 10%, while the constraints on Si/Fe, S/Fe, and Cr/Fe are at the 15% level, and Mn/Fe is measured with a 20% uncertainty. The average biases in determining the chemical composition using archival CCD spectra from XMM-Newton and Suzaku range typically from 15-40%. A simple model in which the enrichment pattern in the Perseus Cluster core and the proto-solar nebula are identical gives a surprisingly good description of the high-resolution X-ray spectroscopy results, with χ 2 = 10.7 for 10 d.o.f. However, this pattern is challenging to reproduce with linear combinations of existing supernova nucleosynthesis calculations, particularly given the precise measurements of intermediate α-elements enabled by Hitomi. We discuss in detail the degeneracies between various supernova progenitor models and explosion mechanisms, and the remaining uncertainties in these theoretical models. We suggest that including neutrino physics in the core-collapse supernova yield calculations may improve the agreement with the observed pattern of α-elements in the Perseus Cluster core. Our results provide a complementary benchmark for testing future nucleosynthesis calculations required to understand the origin of chemical elements.

MicroRNAs have recently been identified as regulators that modulate target gene expression and are suggested to be involved in the development and progression of endometriosis. This study was undertaken to analyze the expression level of in paired ovarian endometrioma and eutopic endometrium from women with endometriosis, and to investigate the contribution of miR-199a to the invasive capability of endometrial stromal cells (ESCs). Cell adhesion, migration and Matrigel invasion assays were carried out to measure the invasiveness of ESCs. Bioinformatics prediction, reporter gene assay, PCR, western blotting and ELISA were performed to identify miR-199a targets and related signaling pathways. The results showed that the expression level of miR-199a was lower in the eutopic endometrium from women with endometriosis, and even lower in the paired ovarian endometrioma, compared with the expression in normal controls. Moreover, ectopic expression of miR-199a attenuated ESC adhesion, migration and invasiveness. MiR-199a targeted and inhibited IkappaB kinase beta (IKKb) in ESCs. Accompanied by IKKb reduction, miR-199a suppressed nuclear factor-kappa B (NF-kB) pathway activation and interleukin-8 (IL-8) production in ESCs. All these findings suggest that miR-199a, down-regulated in endometriosis, attenuates the invasive capability of ESCs in vitro partly through IKK/NF-kB pathway suppression and reduced IL-8 expression. In conclusion, miR-199a could be involved in the pathogenesis of endometriosis.

Four decades ago, the firm detection of an Fe-K emission feature in the X-ray spectrum of the Perseus cluster revealed the presence of iron in its hot intracluster medium (ICM). With more advanced missions successfully launched over the last 20 years, this discovery has been extended to many other metals and to the hot atmospheres of many other galaxy clusters, groups, and giant elliptical galaxies, as evidence that the elemental bricks of life -synthesized by stars and supernovae -are also found at the largest scales of the Universe. Because the ICM, emitting in X-rays, is in collisional ionisation equilibrium, its elemental abundances can in principle be accurately measured. These abundance measurements, in turn, are valuable to constrain the physics and environmental conditions of the Type Ia and core-collapse supernovae that exploded and enriched the ICM over the entire cluster volume. On the other hand, the spatial distribution of metals across the ICM constitutes a remarkable signature of the chemical history and evolution of clusters, groups, and ellipticals. Here, we summarise the most significant achievements in measuring elemental abundances in the ICM, from the very first attempts up to the era of XMM-Newton, Chandra, and Suzaku and the unprecedented results obtained by Hitomi. We also discuss the current systematic limitations of these measurements and how the future missions XRISM and Athena will further improve our current knowledge of the ICM enrichment.

Previous studies have shown that CIZA J2242.8+5301 (the 'Sausage' cluster, z = 0.192) is a massive merging galaxy cluster that hosts a radio halo and multiple relics. In this paper we present deep, high fidelity, low-frequency images made with the LOw-Frequency Array (LOFAR) between 115.5 and 179 MHz. These images, with a noise of 140 µJy/beam and a resolution of θ beam = 7.3 × 5.3 , are an order of magnitude more sensitive and five times higher resolution than previous low-frequency images of this cluster. We combined the LOFAR data with the existing GMRT (153, 323, 608 MHz) and WSRT (1.2, 1.4, 1.7, 2.3 GHz) data to study the spectral properties of the radio emission from the cluster. Assuming diffusive shock acceleration (DSA), we found Mach numbers of M n = 2.7 +0.6 −0.3 and M s = 1.9 +0.3 −0.2 for the northern and southern shocks. The derived Mach number for the northern shock requires an acceleration efficiency of several percent to accelerate electrons from the thermal pool, which is challenging for DSA. Using the radio data, we characterised the eastern relic as a shock wave propagating outwards with a Mach number of M e = 2.4 +0.5 −0.3 , which is in agreement with M X e = 2.5 +0.6 −0.2 that we derived from Suzaku data. The eastern shock is likely to be associated with the major cluster merger. The radio halo was measured with a flux of 346 ± 64 mJy at 145 MHz. Across the halo, we observed a spectral index that remains approximately constant (α 145 MHz-2.3 GHz across ∼1 Mpc 2 = −1.01 ± 0.10) after the steepening in the post-shock region of the northern relic. This suggests a generation of post-shock turbulence that re-energies aged electrons.