Author Correction: Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet

Cheng, Kuang Yao; Lin, Zhi; Cheng, Yu-Pin; Chiu, Hsien‐Tang; Yeh, Nai-Lun; Wu, Tung‐Kung; Wu, Jong-Shinn

doi:10.1038/s41598-018-31449-8

Cited by 5 publications

(5 citation statements)

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“…In contrast to normal wound healing processes that are characterized by activation of the TGFβ signaling, chronic nonhealing wounds have attenuated TGFβ signaling in the epidermis [ 26 ]. In other previous reports, MP treatment was indicated to increase TGFβ expression and enhance wound healing in streptozotocin (STZ)-induced diabetic rats [ 20 ], and it delayed the re-epithelialization of wounds when NO synthesis was inhibited [ 48 ]. NO synthesis in the epidermis of chronic wounds is shown to contribute to TGFβ signaling activation [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…By adjusting the composition of ROS and RNS produced by MP, MP treatment can be used for different biomedical applications, including sterilization, disinfection, and wound treatment [ 16 , 17 , 18 , 19 ]. An increasing number of exploratory preclinical and clinical studies have evaluated MP treatment for healing chronic diabetic wounds [ 20 , 21 ]. We previously developed a capillary tube-based MP device for treating burn wounds [ 18 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice

Shao

Liao

et al. 2021

IJMS

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The delayed healing response of diabetic wounds is a major challenge for treatment. Negative pressure wound therapy (NPWT) has been widely used to treat chronic wounds. However, it usually requires a long treatment time and results in directional growth of wound healing skin tissue. We investigated whether nonthermal microplasma (MP) treatment can promote the healing of skin wounds in diabetic mice. Splint excision wounds were created on diabetic mice, and various wound healing parameters were compared among MP treatment, NPWT, and control groups. Quantitative analysis of the re-epithelialization percentage by detecting Ki67 and DSG1 expression in the extending epidermal tongue (EET) of the wound area and the epidermal proliferation index (EPI) was subsequently performed. Both treatments promoted wound healing by enhancing wound closure kinetics and wound bed blood flow; this was confirmed through histological analysis and optical coherence tomography. Both treatments also increased Ki67 and DSG1 expression in the EET of the wound area and the EPI to enhance re-epithelialization. Increased Smad2/3/4 mRNA expression was observed in the epidermis layer of wounds, particularly after MP treatment. The results suggest that the Smad-dependent transforming growth factor β signaling contributes to the enhancement of re-epithelialization after MP treatment with an appropriate exposure time. Overall, a short-term MP treatment (applied for 30 s twice a day) demonstrated comparable or better efficacy to conventional NPWT (applied for 4 h once a day) in promoting wound healing in diabetic mice. Thus, MP treatment exhibits promise for treating diabetic wounds clinically.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice

Shao

Liao

et al. 2021

IJMS

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“…The initial studies (granulation tissue experiment) allowed 7 days for wound recovery but was modified to 6 days for subsequent studies to ensure that wounds were not completely closed at harvesting should a test material increase, rather decrease healing. Previous studies examining the effects of diabetes on wound repair used animals that are diabetic through genetic abnormalities ( 47 , 48 ) or through administration of compounds such as streptozotocin ( 49 , 50 ). In contrast, our hypothesis was not reliant on manipulating glucose control in the test animals and we therefore used non-diabetic animals.…”

Section: Discussionmentioning

confidence: 99%

Intralesional Infiltrations of Cell-Free Filtrates Derived from Human Diabetic Tissues Delay the Healing Process and Recreate Diabetes Histopathological Changes in Healthy Rats

Berlanga‐Acosta

Fernández‐Mayola

Mendoza‐Marí

et al. 2021

Front. Clin. Diabetes Healthc.

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Lower limb ulcers in type-2 diabetic patients are a frequent complication that tributes to amputation and reduces survival. We hypothesized that diabetic healing impairment and other histopathologic hallmarks are mediated by a T2DM-induced tissue priming/metabolic memory that can be transferred from humans to healthy recipient animals and consequently reproduce diabetic donor’s phenotypes. We examined the effect of human T2DM tissue homogenates injected into non-diabetic rat excisional wounds. Fresh granulation tissue, popliteal artery, and peroneal nerve of patients with T2DM were obtained following amputation. Post-mammoplasty granulation and post-traumatic amputation-tissue of normal subjects acted as controls. The homogenates were intralesionally injected for 6–7 days into rats’ excisional thickness wounds. Infiltration with the different homogenates caused impaired wound closure, inflammation, nerve degeneration, and arterial thickening (all P < 0.01 vs relevant control) resembling histopathology of diabetic donor tissues. Control materials caused marginal inflammation only. Infiltration with glycated bovine albumin provoked inflammation and wound healing delay but did not induce arterial thickening. The reproduction of human diabetic traits in healthy recipient animals through a tissue homogenate support the notion on the existence of tissue metabolic memory-associated and transmissible factors, involved in the pathogenesis of diabetic complications. These may have futuristic clinical implications for medical interventions.

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“…We followed the methods of others for randomization and grouping of animals [ 1 ]. We randomized fifty diabetic male rats into 5 groups.…”

Section: Methodsmentioning

confidence: 99%

“…Diabetes mellitus, a metabolic disease, is a public issue which results in wounds in chronic form as a result of accumulation of anomalous blood glucose and results in neuropathy, arterial impairment, and disturbing function of numerous tissues and organs [ 1 ]. Lots of human beings are affected by diabetes, and it consumes bulky amount of medical expenses.…”

Section: Introductionmentioning

confidence: 99%

Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats

Ali

Najafpour

Farahpour

et al. 2021

BioMed Research International

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Objective. The aim of the present study was to investigate the effect of cinnamon nanoparticles (CNPs) on healing of wounds infected with methicillin-resistant Staphylococcus aurous with human alpha-lactalbumin made lethal to tumor cells sensitization in diabetic rats. Methods. We included fifty diabetic male rats and divided them into 5 groups. There were 10 rats in each group as follows: CONTROL group: we did not infect the CONTROL group. The wound was only covered with sterile saline 0.9% solution (0.1 mL). INFCTD group: in this group, the wounds were infected with MRSA and covered with sterile saline 0.9% solution (0.1 mL). INFCTD-HMLT group: in this group, the wounds were infected with MRSA and HAMLET (100 μg). INFCTD-CNM group: in this group, the wounds were infected with MRSA and 0.1 mL CNPs (1 mg/mL) were applied topically to wounds. INFCTD-HMLT-CNM group: in this group, the wounds were infected with MRSA, HAMLET (100 μg), and 0.1 mL CNPs (1 mg/mL). Results. Bacteriology, wound area reduction measurements, biochemistry, histomorphometrical studies, hydroxyproline levels, and reverse transcription polymerase chain reaction for caspase-3, Bcl-2, and p53 showed significant difference between rats in the INFCTD-HMT-CNM group in comparison with other groups ( P < 0.05 ). Conclusions. Accelerated healing of diabetic wounds infected with MRSA showed that local application of cinnamon nanoparticles along with HAMLET sensitization on S. aureus-infected wound could be taken into consideration.

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Author Correction: Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Cited by 5 publications

References 0 publications

Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice

Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice

Intralesional Infiltrations of Cell-Free Filtrates Derived from Human Diabetic Tissues Delay the Healing Process and Recreate Diabetes Histopathological Changes in Healthy Rats

Accelerative Effect of Cinnamon Nanoparticles as well as HAMLET on Healing of Wounds Infected with MRSA in Diabetic Rats

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