Author Correction: Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

Abstract

The original version of this Article contained an error in the spelling of the author Christopher A. McCulloch, which was incorrectly given as Christopher McCulloch. This has now been corrected in both the PDF and HTML versions of the Article.

Cancer-Associated Fibroblasts in Oral Cancer: A Current Perspective on Function and Potential for Therapeutic Targeting

“…The recruitment of immune cells by CAF is usually described in terms of soluble immunomodulatory factors, such as CXCL10 (C-X-C motif chemokine ligand 10), IL-6, MCP-1 [ 96 ], but recently a novel mechanism for recruitment of macrophages was proposed by Pakshir et al [ 97 ], who demonstrated that macrophages can sense ECM deformation resulting from myofibroblast contraction, and migrate towards them. This mechanosensing mechanism could potentially attract macrophages into CAF-rich tumours independent of chemotactic factors.…”

The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

“…Apart from stroma cells, such as tissue fibroblasts, immune cells can affect the mechanical properties of the extracellular matrix microenvironment (Hynes and Naba, 2012 ; Cox et al, 2013 ; Gonzalez et al, 2018 ; Pakshir et al, 2019 ; D'Urso and Kurniawan, 2020 ) and other nearby cells, such as cancer cells (Fiegl et al, 2006 ; Zhan et al, 2017 ; Zheng and Li, 2020 ). Thus, these immune cell types, encompassing γδT-cells, B-lymphocytes, tumor-associated macrophages, CD8+ and CD4+ lymphocytes, natural killer cells, dendritic cells, T-helper-1 (Th1) cells, Th9 cells and M1 macrophages, T-regulatory (Treg) cells, N1 and N2 neutrophils and cancer associated eosinophiles need to be included in this scenario of cell adhesion and migration (Stankovic et al, 2019 ; Grisaru-Tal et al, 2020 ).…”