The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

Mierke, Claudia Tanja

doi:10.3389/fcell.2021.720494

“…From this review work, both integrins and laminins were observed to be upregulated in PD (15, 16, 90, 97, 103-105). Furthermore, the significance of cell adhesion for cell survival and physiology highlights the importance of proper communication between ECM and integrins (141). These evidences, together with dysregulation of their signaling pathways and individual genes in PD, underline integrins as a potential and valid target molecules for PD treatment.…”

Section: Discussionmentioning

confidence: 99%

Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson’s disease: A systematic review

Rike

¹

,

Stern

²

2023

Preprint

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The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network of bioactive macromolecules that modulate cellular events. Structural, organizational and functional changes in these macromolecules due to genetic variation or environmental stressors are thought to affect the cellular functions, and may result in disease. Most mechanistic studies to date usually focus on the cellular aspects of diseases and pay less attention to the relevance of the processes governing the dynamic nature of the extracellular matrix on disease pathogenesis. Here in this review, we gathered postmortem brain tissue and induced pluripotent stem cell (iPSC)-related studies from PubMed and Google scholar to identify, summarize and describe common macromolecular alterations in the expression of brain ECM components in Parkinson’s disease (PD). According to proteomic studies, proteins such as collagens, fibronectin, annexins and tenascins were recognized to be differentially expressed in Parkinson’s disease. Transcriptomic studies displayed dysregulated pathways including ECM-receptor interaction, focal adhesion, and cell adhesion molecules in Parkinson’s disease. Limited number of relevant studies were accessed from our search indicating that much work still remains to be done to better understand the roles of the ECM in neurodegeneration and Parkinson’s disease. However, we believe that our review will elicit focused primary studies and thus, support the ongoing efforts of the discovery and development of diagnostic biomarkers as well as therapeutic agents for Parkinson’s disease.

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“…Next, stress relaxation is an important parameter to explain cell growth because it is responsible for the ability of cells to engage their clutch in transmitting their traction to enable spreading and actively deform their surrounding matrix for building a proper growth microenvironment [ 30 , 31 ]. The stress relaxation time obtained by fitting the individual normalized stress relaxation curve ( Figure 1 b) to the standard linear solid equation was hundreds of milliseconds.…”

Section: Resultsmentioning

confidence: 99%

Viscoelastic Liquid Matrix with Faster Bulk Relaxation Time Reinforces the Cell Cycle Arrest Induction of the Breast Cancer Cells via Oxidative Stress

Najmina

¹

,

Ebara

²

,

Ohmura

³

et al. 2022

IJMS

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The reactivating of disseminated dormant breast cancer cells in a soft viscoelastic matrix is mostly correlated with metastasis. Metastasis occurs due to rapid stress relaxation owing to matrix remodeling. Here, we demonstrate the possibility of promoting the permanent cell cycle arrest of breast cancer cells on a viscoelastic liquid substrate. By controlling the molecular weight of the hydrophobic molten polymer, poly(ε-caprolactone-co-D,L-lactide) within 35–63 g/mol, this study highlights that MCF7 cells can sense a 1000 times narrower relaxation time range (80–290 ms) compared to other studies by using a crosslinked hydrogel system. We propose that the rapid bulk relaxation response of the substrate promotes more reactive oxygen species generation in the formed semi-3D multicellular aggregates of breast cancer cells. Our finding sheds light on the potential role of bulk stress relaxation in a viscous-dominant viscoelastic matrix in controlling the cell cycle arrest depth of breast cancer cells.

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“…From this review work, both integrins and laminins were observed to be upregulated in PD [ 67 , 68 , 113 , 120 , 126 , 127 , 128 ]. Furthermore, the significance of cell adhesion for cell survival and physiology highlights the importance of proper communication between the ECM and integrins [ 159 ]. This evidence, together with the dysregulation of their signaling pathways and individual genes in PD, underlines integrins as a potential and valid target molecule for PD treatment.…”

Section: Discussionmentioning

confidence: 99%

Proteins and Transcriptional Dysregulation of the Brain Extracellular Matrix in Parkinson’s Disease: A Systematic Review

Rike

¹

,

Stern

²

2023

IJMS

View full text Add to dashboard Cite

The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network of bioactive macromolecules that modulate cellular events. Structural, organizational, and functional changes in these macromolecules due to genetic variation or environmental stressors are thought to affect cellular functions and may result in disease. However, most mechanistic studies to date usually focus on the cellular aspects of diseases and pay less attention to the relevance of the processes governing the dynamic nature of the extracellular matrix in disease pathogenesis. Thus, due to the ECM’s diversified biological roles, increasing interest in its involvement in disease, and the lack of sufficient compiled evidence regarding its relationship with Parkinson’s disease (PD) pathology, we aimed to compile the existing evidence to boost the current knowledge on the area and provide refined guidance for the future research. Here, in this review, we gathered postmortem brain tissue and induced pluripotent stem cell (iPSC)-related studies from PubMed and Google Scholar to identify, summarize and describe common macromolecular alterations in the expression of brain ECM components in Parkinson’s disease (PD). A literature search was conducted up until 10 February 2023. The overall hits from the database and manual search for proteomic and transcriptome studies were 1243 and 1041 articles, respectively. Following a full-text review, 10 articles from proteomic and 24 from transcriptomic studies were found to be eligible for inclusion. According to proteomic studies, proteins such as collagens, fibronectin, annexins, and tenascins were recognized to be differentially expressed in Parkinson’s disease. Transcriptomic studies displayed dysregulated pathways including ECM–receptor interaction, focal adhesion, and cell adhesion molecules in Parkinson’s disease. A limited number of relevant studies were accessed from our search, indicating that much work remains to be carried out to better understand the roles of the ECM in neurodegeneration and Parkinson’s disease. However, we believe that our review will elicit focused primary studies and thus support the ongoing efforts of the discovery and development of diagnostic biomarkers as well as therapeutic agents for Parkinson’s disease.

show abstract

The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

Cited by 7 publications

References 87 publications

Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson’s disease: A systematic review

Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson’s disease: A systematic review

Viscoelastic Liquid Matrix with Faster Bulk Relaxation Time Reinforces the Cell Cycle Arrest Induction of the Breast Cancer Cells via Oxidative Stress

Proteins and Transcriptional Dysregulation of the Brain Extracellular Matrix in Parkinson’s Disease: A Systematic Review

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