Auswirkungen soziomedizinischer Risikofaktoren auf den Verlauf des Ovarialkarzinoms

Abstract

This newly described link between patients' psychological constitution and course of disease suggests psychotherapeutic support to be helpful for ovarian carcinoma patients. Risk factors, furthermore, may have an opposite effect on both cancer incidence and prognosis. The latter is discussed on the background of an ovarian carcinogenesis threshold model.

Influence of body mass index on prognosis in gynecological malignancies

“…In the case of the tumor, however, it is probably more aggressive than that which develops in a regular situation and under the influence of protective factors [39].…”

“…4 The effect of body mass index on overall survival in the total patient group of patients with ovarian cancer (Kaplan-Meier survival analysis, log rank = 3.74; df = 1; p = 0.053). Mean survival time of patients who died from ovariancancer is given below for the different BMI categories incidence of ovarian cancers but worsens the patients' prognosis [39,40]. This paradox has been explained by the threshold model, which suggests that under the influence of cancer-promoting factors the development of disease takes less time, fewer gene mutations and leads to more tumors.…”

Prevalence rate and influencing factors of preoperative anxiety and depression in gastric cancer patients in China: Preliminary study

“… 44 Research in psychosocial oncology and psychoneuroimmunology has found an interaction between inflammatory immune response and psychosocial factors. 45 Inflammation is an important component of tumour progression, and inflammatory cells in tumour microenvironments are critical precursors for the genesis and development of tumours; a series of inflammatory mediators released by tumour cells change the tumour microenvironment and facilitate proliferation and metastasis. 46 The peripheral neutrophil level can reflect the systemic inflammatory state in humans.…”