Austrian consensus on the definition and treatment of portal hypertension and its complications (Billroth II)

Peck‐Radosavljevic, Markus; Angermayr, Bernhard; Datz, Christian; Ferlitsch, Arnulf; Ferlitsch, Monika; Fuhrmann, Valentin; Häfner, Michael; Kramer, Ludwig; Maieron, A; Payer, BA; Reiberger, Thomas; Stauber, Rudolf; Steininger, R.; Trauner, Michael; Thurnher, Siegfried; Ulbrich, Gregor; Vogel, Wolfgang; Zoller, Heinz; Graziadei, Ivo

doi:10.1007/s00508-013-0337-z

Cited by 45 publications

(55 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Then a balloon catheter (Pejcl Medicintechnik, Austria)[22] was chosen to cannulate the liver vein via the transjugular access as described previously [23]. CSPH was defined as ≥10 mm Hg [24]. …”

Section: Methodsmentioning

confidence: 99%

Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis

Paternostro

Wagner

Reiberger

et al. 2016

Wien Klin Wochenschr

Self Cite

View full text Add to dashboard Cite

SummaryBackground and aimsVitamin D deficiency is frequent in patients with cirrhosis. The aims of this study were to evaluate the relation of vitamin D status to portal hypertension, degree of liver dysfunction and survival.MethodsPatients with cirrhosis who have been tested for 25-OH-vitamin D levels were retrospectively included. Vitamin D deficiency was defined as 25-OH-vitamin D levels <10 ng/ml. Child–Pugh score, model for end-stage liver disease (MELD) and available hepatic venous pressure gradient (HVPG) were recorded. Mortality was documented during follow-up.ResultsA total of 199 patients were included. Prevalence of vitamin D deficiency (<10 ng/ml) was 40% (79/199), with 14% in Child–Pugh stage A, 39% in Child–Pugh stage B and 47% in Child–Pugh stage C (p = 0.001). Vitamin D deficiency was more common in patients with clinically significant portal hypertension (CSPH, HVPG ≥ 10 mm Hg) than in patients without (43.5% vs. 24.4%, p = 0.025). Significantly more deaths were observed in patients with vitamin D deficiency (32.9%, 26/79 vs. 13.3%, 16/120; p = 0.001). COX regression found presence of hepatocellular carcinoma (p < 0.001; HR: 5.763 95%CI:2.183–15.213), presence of CSPH (p = 0.026; HR: 5.487 95%CI: 1.226–24.55) and Child–Pugh stage C (p = 0.003; HR:5.429 95%CI: 1.771–16.638) as independent risk factors for mortality. Furthermore we could show a tendency towards group vitamin D deficiency being an independent risk factor (p = 0.060; HR: 1.86 95%CI:0.974–3.552).ConclusionsVitamin D levels progressively decrease in more advanced Child stages and in patients with increasing HVPG. Vitamin D deficiency might be a valuable predictor of mortality in cirrhosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis

Paternostro

Wagner

Reiberger

et al. 2016

Wien Klin Wochenschr

Self Cite

View full text Add to dashboard Cite

show abstract

“…Paracenteses were performed as clinically indicated . Patients undergoing large‐volume paracentesis (> 5L) received 8‐g human serum albumin per liter of ascites removed . The index paracentesis was defined as the first paracentesis at our center.…”

Section: Methodsmentioning

confidence: 99%

Impact of acute kidney injury on prognosis of patients with liver cirrhosis and ascites: A retrospective cohort study

Bucsics

Mandorfer

Schwabl

et al. 2015

J of Gastro and Hepatol

Self Cite

View full text Add to dashboard Cite

show abstract

“…In accordance with national guidelines [25], [26], albumin was administered in LVPs and patients received long-term prophylaxis with quinolones after SBP development. SBP was diagnosed if the ascitic PMN count was>250cells x mL -1 in absence of an intra-abdominal source of infection or any other explanation for an elevated PMN count [26]–[28].…”

Section: Methodsmentioning

confidence: 99%

“…SBP was diagnosed if the ascitic PMN count was>250cells x mL -1 in absence of an intra-abdominal source of infection or any other explanation for an elevated PMN count [26]–[28].…”

Section: Methodsmentioning

confidence: 99%

Proton Pump Inhibitor Intake neither Predisposes to Spontaneous Bacterial Peritonitis or Other Infections nor Increases Mortality in Patients with Cirrhosis and Ascites

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background and AimThe aim of this study was to assess the impact of proton pump inhibitor (PPI) intake on the development of spontaneous bacterial peritonitis (SBP) or other infections, as well as on mortality, in a thoroughly documented cohort of patients with cirrhosis and ascites.Patients and MethodsWe performed a retrospective analysis of follow-up data from 607 consecutive patients with cirrhosis undergoing their first paracentesis at a tertiary center. A binary logistic regression model investigating the association between PPI intake and SBP at the first paracentesis was calculated. Competing risk analyses and Cox models were used to investigate the effect of PPIs on the cumulative incidence of SBP or other infections and transplant-free survival, respectively. Adjustments were made for age, hepatocellular carcinoma, history of variceal bleeding, varices and model of end-stage liver disease score.ResultsEighty-six percent of patients were receiving PPIs. After adjusting for potential confounding factors, PPI intake was neither associated with increased SBP prevalence at the first paracentesis (odds ratio (OR):1.11,95% confidence interval (95%CI):0.6–2.06; P = 0.731) nor cumulative incidence of SBP (subdistribution hazard ratio (SHR): 1.38; 95%CI:0.63–3.01; P = 0.42) and SBP or other infections (SHR:1.71; 95%CI:0.85–3.44; P = 0.13) during follow-up. Moreover, PPI intake had no impact on transplant-free survival in both the overall cohort (hazard ratio (HR):0.973,95%CI:0.719–1.317; P = 0.859) as well as in the subgroups of patients without SBP (HR:1.01,95%CI:0.72–1.42; P = 0.971) and without SBP or other infections at the first paracentesis (HR:0.944,95%CI:0.668–1.334; P = 0.742).ConclusionsThe proportion of cirrhotic patients with PPI intake was higher than in previous reports, suggesting that PPI indications were interpreted liberally. In our cohort with a particularly high prevalence of PPI intake, we observed no association between PPIs and SBP or other infections, as well as mortality. Thus, the severity of liver disease and other factors, rather than PPI treatment per se may predispose for infectious complications.

show abstract

Austrian consensus on the definition and treatment of portal hypertension and its complications (Billroth II)

Cited by 45 publications

References 115 publications

Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis

Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis

Impact of acute kidney injury on prognosis of patients with liver cirrhosis and ascites: A retrospective cohort study

Proton Pump Inhibitor Intake neither Predisposes to Spontaneous Bacterial Peritonitis or Other Infections nor Increases Mortality in Patients with Cirrhosis and Ascites

Contact Info

Product

Resources

About