Ausência de correlação entre as alterações morfológicas e bioquímicas na microcirculação de pacientes com esclerose sistêmica

Kayser, Cristiane; Andrade, Luís Eduardo Coelho

doi:10.1590/s0482-50042004000100005

Cited by 3 publications

(8 citation statements)

References 16 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…O FR (10,31) foi considerado objetivo quando visto pelo médico e subjetivo quando referido pelo paciente. As alterações de polpas digitais consideradas foram microcicatrizes e ulcerações e, quando presentes, foram avaliadas se atuais ou pregressas.…”

Section: Study Of Macrovasculature By Doppler Ultrasound In Systemic unclassified

Estudo da macrovasculatura por ultra-sonografia Doppler na esclerose sistêmica

Godoi¹,

Barbosa²,

Godoi³

et al. 2008

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

Section: Study Of Macrovasculature By Doppler Ultrasound In Systemic unclassified

Estudo da macrovasculatura por ultra-sonografia Doppler na esclerose sistêmica

Godoi¹,

Barbosa²,

Godoi³

et al. 2008

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

“…Essas lesões vasculares são caracterizadas principalmente por proliferação miointimal, por exuberante atividade de fibroblasto e disfunção endotelial, presentes nas pequenas artérias e microcirculação, nos estágios iniciais da doença 21,22 .…”

Section: Doença Microvascular Na Esunclassified

Envolvimento macrovascular e esclerose sistêmica

Godoi

Barbosa²,

Godoi³

et al. 2009

J. vasc. bras.

View full text Add to dashboard Cite

ResumoEste artigo tem como objetivo revisar os aspectos descritos na literatura sobre o acometimento da macrovasculatura na esclerose sistêmica e avaliar a ocorrência e distribuição das alterações macrovasculares nos pacientes com esclerose sistêmica através do eco-Doppler e do índice tornozelo-braço, além da associação desses achados com as características demográficas, forma clínica, tempo de evolução da doença, fenômeno de Raynaud (FR), alterações digitais, ulcerações de membros, reabsorção de falange, amputação, bem como fatores de risco e antecedentes da doença ateromatosa. O estudo foi prospectivo, do tipo série de casos, constituído de 20 pacientes, sendo 19 do sexo feminino, com idade média de 46,30 anos. Todos os pacientes tinham fenômeno de Raynaud objetivo, 85% a forma clínica difusa, 55% alteração de polpa digital, 15% úlcera atual de membros, 25% reabsorção de falange, nenhuma amputação e 70% de um a quatro fatores de risco. Foram estudadas pelo eco-Doppler as artérias aorta e carótida, dos membros inferiores e superiores, para a avaliação de espessamento do complexo íntimo-medial e presença de placas e aneurismas. Nas artérias dos membros inferiores, foi também realizado o índice tornozelo-braço. O índice tornozelo-braço foi normal em todos os pacientes; entretanto, 12 (60%) destes apresentaram doença macrovascular pelo eco-Doppler, sendo nove (45%) na aorta, seis (30%) nas carótidas, uma (5%) nas artérias dos membros superiores e sete (35%) nas dos membros inferiores. Observou-se associação entre doença macrovascular e alterações de polpas digitais (p = 0,0045). A doença macrovascular foi identificada em 60% dos pacientes através do eco-Doppler, mas não pelo índice tornozelo-braço, que foi normal em todos. Verificou-se associação significante da doença macrovascular com as alterações atuais de polpas digitais, o que não ocorreu com as demais variáveis estudadas. Palavras-chave:Esclerose sistêmica, efeito Doppler, aterosclerose. AbstractThe objectives of this article are to review aspects described in the literature on macrovasculature onset in systemic sclerosis and to assess occurrence and distribution of macrovascular alterations in patients with systemic sclerosis using Doppler ultrasound and ankle-brachial index. In addition, the article evaluates the association of these findings with demographic characteristics, clinical form, clinical course of the disease, Raynaud's phenomenon, digital changes, limb ulcers, reabsorption of phalanges, amputation, and risk factors and antecedents of atheromatous disease. A prospective, case series study of 20 patients was performed. The sample was comprised of 19 women, with a mean age of 46.30 years. All patients had objective Raynaud's phenomenon, 85% were diffuse, 55% had digital pulp changes, 15% current limb ulcer, 25% reabsorption of phalange, no amputations, and 70% presented one to four risk factors. Studies were performed by color Doppler ultrasound of the aortic and carotid arteries and lower and upper limb arteries to assess thickening of the inti...

show abstract

“…1,2 It is a disease of low incidence, with an average of 4 to 19 new cases per million inhabitants and preferentially affects females (4:1). 1 The age group most affected is between the third and fi fth decades of life. 3,4 Its etiopathogenesis has not been completely clarifi ed.…”

Section: Introductionmentioning

confidence: 99%

“…The microcirculation undergoes a process of primary vasculitis, which in conjunction with differing vessel thicknesses may cause total obliteration of the vessel due to collagen deposition, thereby leading to clinical manifestations of varying degrees of severity. 1,2,3,5 This disease presents a variety of clinical features. Raynaud's phenomenon is usually its fi rst manifestation, and skin thickening, esophageal dysmotility, restrictive pulmonary disease, pulmonary hypertension, arthralgia, myopathy, myocardiopathy and progressive renal insuffi ciency are also observed.…”

Section: Introductionmentioning

confidence: 99%

“…Raynaud's phenomenon is usually its fi rst manifestation, and skin thickening, esophageal dysmotility, restrictive pulmonary disease, pulmonary hypertension, arthralgia, myopathy, myocardiopathy and progressive renal insuffi ciency are also observed. [1][2][3] The thickening of the skin (scleroderma) presents an initial phase of edema that makes the skin swollen and shiny, followed by a hardening phase in which the skin starts to have a dried-out, rough and inelastic appearance, and a third phase in which, in most patients, the skin gradually starts to take on an atrophied and thin appearance. 1,3 The orofacial manifestations include stiffness and atrophy of the facial skin that gives the face a mask-like appearance; progressive limitation of mouth opening; skin and mucosa pigmentation (melanoleukoderma) and telangiectasia; hardening and loss of elasticity of the oral mucosa; hardening of the tongue and soft palate; varying degrees of xerostomy; periodontitis; and diffi culty in chewing, speaking and swallowing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and radiographic study of orofacial alterations in patients with systemic sclerosis

Marcucci

Abdala

2009

Braz. oral res.

View full text Add to dashboard Cite

Systemic sclerosis (SS) is an autoimmune disease with great repercussions on the hard and soft tissues of the orofacial region. The aim of this study was to investigate the relationship between mandibular osteolysis and mouth opening measurements, duration of disease and presence/absence of teeth. Twenty-fi ve subjects were selected: 15 diagnosed with systemic sclerosis and 10 healthy controls. The SS patients were grouped according to the presence (group I) or absence (group II) of mandibular osteolysis. The healthy subjects served as the control group (III). All of them underwent panoramic radiography on Ortophos ® equipment (Siemens) and were clinically examined, with mouth opening measurement. We observed that group I had a longer duration of the disease than group II (p = 0.003). Groups I and II presented the same mean mouth opening. There was an increasing correlation between mouth opening and duration of the disease in group I (p = 0.095), but this was not observed in group II (p = 0.596). There was no correlation between presence/absence of teeth and osteolysis (p > 0.999), or between presence/absence of teeth and side of osteolysis (p = 0.143). We could conclude that osteolysis seemed to develop in patients with a longer duration of the disease, but did not modify the degree of mouth opening in relation to patients without osteolysis, and the presence/absence of teeth was not signifi cant. On the other hand, in the osteolysis cases, the longer the duration of the disease, the greater the opening of the mouth.

show abstract

Ausência de correlação entre as alterações morfológicas e bioquímicas na microcirculação de pacientes com esclerose sistêmica

Cited by 3 publications

References 16 publications

Estudo da macrovasculatura por ultra-sonografia Doppler na esclerose sistêmica

Estudo da macrovasculatura por ultra-sonografia Doppler na esclerose sistêmica

Envolvimento macrovascular e esclerose sistêmica

Clinical and radiographic study of orofacial alterations in patients with systemic sclerosis

Contact Info

Product

Resources

About