“…[5] in this issue of Oncotarget constitutes a particularly good example of how cancer cells can exploit their metabolic activities to resist to radiotherapy, and of what can be done therapeutically to counteract such intrinsic radioresistance. As metabolic entities, cancer cells are deemed to reach three objectives: the production of enough energy for cell proliferation and repair (bioenergetics), the generation of building blocks for the same purposes (biosynthesis), and the maintenance of a pool of reductive molecules that protect against redox stress [6].…”