ROS and radiotherapy: more we care

Sonveaux, Pierre

doi:10.18632/oncotarget.16613

Cited by 32 publications

(25 citation statements)

References 8 publications

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“…In fact, the availability of the local molecular oxygen improves the efficacy of radiotherapy, as DNA lesions caused by ROS produced during water radiolysis react with oxygen to form stable DNA peroxides (Sonveaux, 2017). In fact, the availability of the local molecular oxygen improves the efficacy of radiotherapy, as DNA lesions caused by ROS produced during water radiolysis react with oxygen to form stable DNA peroxides (Sonveaux, 2017).…”

Section: Lack Of Oxygenmentioning

confidence: 99%

“…This lack of oxygen within the spheroids has been also linked to a decrease in the cell damage mediated by radiation. In fact, the availability of the local molecular oxygen improves the efficacy of radiotherapy, as DNA lesions caused by ROS produced during water radiolysis react with oxygen to form stable DNA peroxides (Sonveaux, 2017). Having this in mind, the cancer cells that receive less oxygen, such as those from spheroids core, are typically more radioresistant (Gray, Conger, Ebert, Hornsey, & Scott, 1953;Grimes & Partridge, 2015).…”

Section: Lack Of Oxygenmentioning

confidence: 99%

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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Nunes

Barros

Costa

et al. 2018

Biotech & Bioengineering

505

445

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Three-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described. HIGHLIGHTS•The suitability of 3D cell culture models for drug screening purposes is highlighted. •Spheroids and in vivo human solid tumors structural and functional similarities are emphasized.•The drug resistance mechanisms exhibited by spheroids are described.•Therapeutic approaches used to surpass spheroids' drug resistance mechanisms are described. K E Y W O R D Sdrug resistance, drugs, in vitro models, solid tumors, spheroids

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Section: Lack Of Oxygenmentioning

confidence: 99%

Section: Lack Of Oxygenmentioning

confidence: 99%

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Nunes

Barros

Costa

et al. 2018

Biotech & Bioengineering

505

445

View full text Add to dashboard Cite

show abstract

“…There is enhanced ROS production in irradiated cells The enhanced ROS production is caused by radiolysis of water by ionizing radiation . In fact, it is the increased ROS that contributes to cell‐killing as these ROS can cause DNA lesions.…”

Section: Resultsmentioning

confidence: 99%

“…Reactive oxygen species (ROS) are free radicals or chemically unstable molecules containing oxygen but are more reactive than molecular oxygen . First described only 60 years ago their roles in normal cell function and diseases (eg, cancer and inflammation) are still being unraveled . From being seen as damaging agents produced by phagocytes , it is now known that all cell types produce ROS and that both beneficial and harmful levels of ROS can exist in cellular environments .…”

Section: Introductionmentioning

confidence: 99%

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Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Lee¹,

Suresh²,

Ekpenyong³

2018

Journal of Biophotonics

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Quantum dots (QDs) are semiconductor nanoparticles ranging in size from 2 to 10 nm. QDs are increasingly being developed for biomedical imaging, targeted drug delivery and green energy technology. These have led to much research on QD interactions with various physical, chemical and biological systems. For biological systems, research has focused on the biocompatibility/cytotoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems and bioactive molecules might be used to alter the optoelectronic properties of QDs. Here, it is shown that these properties can be altered by reactive oxygen species (ROS) from chemotherapeutic media and biological cells following controlled changes in cellular activities. Using CdSe/ZnS core-shell QDs, spectroscopic analysis of optically excited QDs with HL60, K562 and T98G cancer cell lines is performed. Our results show statistically significant (P < 0.0001) modulation of the fluorescence emission spectra of the QDs due to the ROS produced by common chemotherapeutic drugs, daunorubicin and doxorubicin and by cells following chemotherapy/radiotherapy. This optical modulation, in addition to assessing ROS generation, will possibly enhance applications of QDs in simultaneous diagnostic imaging and nanoparticle-mediated drug delivery as well as simultaneous ROS assessment and radiosensitization for improved outcomes in cancer treatments. Reactive molecular species produced by biological cells and chemotherapeutic drugs can create electric fields that alter the photophysical properties of QDs, and this can be used for concurrent monitoring of cellular activities, while inducing changes in those cellular activities. K E Y W O R D Scancer, chemotherapy, fluorescence, quantum dot, radiotherapy, reactive oxygen species

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Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Zhou,

Li,

et al. 2024

Advanced Materials

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Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, and producing anticancer microbial agents in situ to suppress tumor growth. Despite the unique advantages of bacteria‐based cancer biotherapy, the insufficient treatment efficiency limits its application in the complete ablation of malignant tumors. The combination of nanomedicine and engineered bacteria has attracted increasing attention owing to their striking synergistic effects in cancer treatment. Engineered bacteria that act as natural vehicles can effectively deliver nanomedicines to tumor sites. Moreover, bacteria provide an opportunity to enhance nanomedicines by modulating the TME and producing substrates to support nanomedicine‐mediated anticancer reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, and catalytic properties, and plays an important role in promoting bacteria‐mediated biotherapies. The synergistic anticancer effects of engineered bacteria and nanomedicines in cancer therapy are comprehensively summarized in this review. Attention is paid not only to the fabrication of nanobiohybrid composites, but also to the interpromotion mechanism between engineered bacteria and nanomedicine in cancer therapy. Additionally, recent advances in engineered bacteria‐synergized multimodal cancer therapies have also been highlighted.This article is protected by copyright. All rights reserved

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ROS and radiotherapy: more we care

Cited by 32 publications

References 8 publications

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

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