AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

Zhou, Lu; Liu, Guojie; Wang, Yang; Liu, Jianling; Zhang, Yajie; Ma, Yong

doi:10.1039/c9ra07404j

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…It has been shown that DNA strands are unable to close the pore entrances below a certain size [386]. Nonetheless, such short sequences can be employed as linkers to block the mesopores with proteins [387], small gold nanoparticles [388] and magnetic γ-Fe 2 O 3 nanoparticles [389].…”

Section: Thermo-responsive Msnsmentioning

confidence: 99%

“…Thermo-Responsive Disassembling Gatekeepers DNA Large DNA strands acting as gatekeepers that dehybridize above a certain temperature, triggering drug release [231,[384][385][386] Short DNA strands used as linkers for grafting bulky gatekeepers (proteins, small nanoparticles) that allow drug release when strands dehybridize upon heating [387][388][389] Peptides…”

Section: Approach Description Referencementioning

confidence: 99%

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Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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Section: Thermo-responsive Msnsmentioning

confidence: 99%

Section: Approach Description Referencementioning

confidence: 99%

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

Siddiqui

Rehman

ul-Haq

et al. 2022

International Journal of Pharmaceutics: X

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Facile fabrication of hypercrosslinked microporous polymer nanospheres for effective inhibition of triple negative breast cancer cells proliferation

Razzaque

Guo

Weng

et al. 2022

Journal of Colloid and Interface Science

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AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

Abstract: Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release.

Cited by 3 publications

References 27 publications

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications

Facile fabrication of hypercrosslinked microporous polymer nanospheres for effective inhibition of triple negative breast cancer cells proliferation

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