Augmented ventilatory activities after airway anaesthesia in humans.

Tanaka, Yukio; Morikawa, Takamichi; Honda, Yoshiyuki

doi:10.2170/jjphysiol.36.645

Cited by 2 publications

(4 citation statements)

References 23 publications

(24 reference statements)

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“…Ventilatory pattern and heart rate at rest (Table 2) In the normoxic measurements, a small but significant decrease in PETCo2 was observed after lidocaine inhalation. In our previous study (TANAKA et al, 1986), however, no appreciable changes in the PETCo2 level were noticed, although we observed the presence of hypoxemia after lidocaine. Therefore, underlying hypoxemia may have stimulated the ventilation to decrease the resting PETCo2.…”

Section: Resultscontrasting

confidence: 69%

“…This phenomenon is believed to be chiefly due to the suppression of the cardioinhibitory center, which is mediated by the activation of pulmonary stretch receptors (STEPHERD and VANHOUTTE, 1979). As discussed in our previous paper (TANAKA et al, 1986), airway anaesthesia seems to preferentially block the stretch receptors (FAHIM and JAIN, 1979;WINNING et al, 1985), although the extent of the blockade is uncertain. Therefore, a decreased heart rate at rest during hypocapnic breathing seems to be conceivable.…”

Section: Resultsmentioning

confidence: 92%

“…Hypoxic responses (Tables 3-5) Lidocaine inhalation caused marked hypoxemia, accompanying a large increase in A-aDo2 (TANAKA et al, 1986). For this reason, it was considered inappropriate to evaluate the hypoxic responses as a function of PETo 2 changes, and (SLUTSKY and REBUCK, 1978) was used to assess the hypoxic responses.…”

Section: Resultsmentioning

confidence: 99%

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Effect of airway anaesthesia on the ventilatory and heart rate responses to isocapnic progressive hypoxia.

1986

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The effect of airway anaesthesia by lidocaine inhalation on the hypoxic ventilatory response was examined together with the heart rate response by the isocapnic progressive hypoxia test in human subjects. During the test, end-tidal P~o2 (PETCo2) was maintained at the resting level. However, because resting PETCoz tends to decrease by airway anaesthesia, we conducted the test at the resting PETCo2 determined both before (normocapnic) and after lidocaine (hypocapnic). Ventilatory and heart rate response were evaluated as a linear function of oxygen saturation of the arterial blood (Sao2). In the "hypocapnic" runs, ventilatory responses tended to be depressed, while the slope of heart rate response-PET~o2 relationship increased after lidocaine. However, when PETC02 was restored to the normocapnic level, ventilation apparently increased from the control, and the augmented slope in the heart rate response disappeared. Although the elevated ventilation in normocapnic hypoxia might be due simply to the increased ventilatory response to C02, we suggested that the augmented slope in the heart rate response in hypocapnic hypoxia might be related not only to PET~o2 level itself but also to the direct effect of airway anaesthesia.Key words : airway anaesthesia, hypoxia, control of breathing, control of heart rate.It has been repeatedly confirmed by many investigators that airway anaesthesia induces enhanced ventilatory response to hypercapnia (CROSS et al., 1976; SULLIVAN and YU,1983;WINNING et al., 1985). However, it seems uncertain at present if this is also the case with response to other ventilatory stimuli. Recently, SULLIVAN and DEWEESE (1985) reported the lack of effect of lidocaine inhalation on hypoxic ventilation, and stated that only hypercapnic ventilation is increased after airway

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Section: Resultscontrasting

confidence: 69%

Section: Resultsmentioning

confidence: 92%

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Effect of airway anaesthesia on the ventilatory and heart rate responses to isocapnic progressive hypoxia.

1986

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“…Our data agree well with the reports that the venti latory response to CCL increased after airway anesthe sia [13,14]. The activity of slowly adapting stretch receptors (SARs) is known to cause respiratory inhibi tion, whereas rapidly adapting stretch receptors pro mote respiratory stimulation [2].…”

Section: Co2 Responsessupporting

confidence: 91%

Effect of Unilateral Pulmonary Vagotomy on Respiratory Control in Man

Takaishi

Isono²,

Nishibayashi³

et al. 1990

Respiration

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We studied the breathing pattern and pulmonary function at rest, and ventilatory responses to progressive hypoxia and hypercapnia in 7 awake patients who had undergone esophageal-carcinoma resection with sectioning of the right pulmonary vagal branch by lymphadenectomy. Twelve control patients, who had received the same surgery without vagotomy, were also studied by the same protocol. Two months after the operation, both patient groups demonstrated substantial depressions in FVC and FEV_1.0, and slight augmentations in breathing frequency, minute ventilation, and occlusion pressure at 0.2 s (P_0.2) at rest. In the vagotomized group, the occlusion pressure responses to hypercapnia (ΔP_0.2/ΔP_aCO₂) and hypoxia (ΔP_0.2/ΔS_aO₂) in terms of response curve slope increased from 1.3 ± 1.2 to 1.9 ± 1.1 cm H₂O/Torr and from 0.29 ± 0.19 to 0.88 ± 0.53 cm H₂O/% (p < 0.05), respectively. Contrary to the vagotomized patients, the nonvagotomized control group exhibited no significant changes in ventilatory chemosensitivities. Furthermore, when comparing the control and vagotomized groups, postoperative ventilatory chemosensitivity responses in terms of both hypercapnic and hypoxic occlusion pressure responses were significantly higher in the latter. We suggest that (1) due to the development of the substantial mechanical limitation in pulmonary functions, the Hering-Breuer inflation reflex became activated after surgery, and (2) a diminished Hering-Breuer reflex effect to inhibit the respiratory centers by unilateral vagotomy may have resulted in augmented ventilatory chemosensitivities

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Augmented ventilatory activities after airway anaesthesia in humans.

Cited by 2 publications

References 23 publications

Effect of airway anaesthesia on the ventilatory and heart rate responses to isocapnic progressive hypoxia.

Effect of airway anaesthesia on the ventilatory and heart rate responses to isocapnic progressive hypoxia.

Effect of Unilateral Pulmonary Vagotomy on Respiratory Control in Man

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