Abstract:The effect of airway anaesthesia by lidocaine inhalation on the hypoxic ventilatory response was examined together with the heart rate response by the isocapnic progressive hypoxia test in human subjects. During the test, end-tidal P~o2 (PETCo2) was maintained at the resting level. However, because resting PETCoz tends to decrease by airway anaesthesia, we conducted the test at the resting PETCo2 determined both before (normocapnic) and after lidocaine (hypocapnic). Ventilatory and heart rate response were eva… Show more
“…They suggested that afferent vagal informa tion is required to elicit an increased rate of breathing in response to hypercapnia and hypoxemia. Little or no effect of airway anesthesia on the hypoxic venti latory and occlusion pressure responses in healthy subjects was reported by Tanaka et al [17] at our insti tute. Three possibilities may account for the discre pancy between those data and the results in this study.…”
We studied the breathing pattern and pulmonary function at rest, and ventilatory responses to progressive hypoxia and hypercapnia in 7 awake patients who had undergone esophageal-carcinoma resection with sectioning of the right pulmonary vagal branch by lymphadenectomy. Twelve control patients, who had received the same surgery without vagotomy, were also studied by the same protocol. Two months after the operation, both patient groups demonstrated substantial depressions in FVC and FEV1.0, and slight augmentations in breathing frequency, minute ventilation, and occlusion pressure at 0.2 s (P0.2) at rest. In the vagotomized group, the occlusion pressure responses to hypercapnia (ΔP0.2/ΔPaCO2) and hypoxia (ΔP0.2/ΔSaO2) in terms of response curve slope increased from 1.3 ± 1.2 to 1.9 ± 1.1 cm H2O/Torr and from 0.29 ± 0.19 to 0.88 ± 0.53 cm H2O/% (p < 0.05), respectively. Contrary to the vagotomized patients, the nonvagotomized control group exhibited no significant changes in ventilatory chemosensitivities. Furthermore, when comparing the control and vagotomized groups, postoperative ventilatory chemosensitivity responses in terms of both hypercapnic and hypoxic occlusion pressure responses were significantly higher in the latter. We suggest that (1) due to the development of the substantial mechanical limitation in pulmonary functions, the Hering-Breuer inflation reflex became activated after surgery, and (2) a diminished Hering-Breuer reflex effect to inhibit the respiratory centers by unilateral vagotomy may have resulted in augmented ventilatory chemosensitivities
“…They suggested that afferent vagal informa tion is required to elicit an increased rate of breathing in response to hypercapnia and hypoxemia. Little or no effect of airway anesthesia on the hypoxic venti latory and occlusion pressure responses in healthy subjects was reported by Tanaka et al [17] at our insti tute. Three possibilities may account for the discre pancy between those data and the results in this study.…”
We studied the breathing pattern and pulmonary function at rest, and ventilatory responses to progressive hypoxia and hypercapnia in 7 awake patients who had undergone esophageal-carcinoma resection with sectioning of the right pulmonary vagal branch by lymphadenectomy. Twelve control patients, who had received the same surgery without vagotomy, were also studied by the same protocol. Two months after the operation, both patient groups demonstrated substantial depressions in FVC and FEV1.0, and slight augmentations in breathing frequency, minute ventilation, and occlusion pressure at 0.2 s (P0.2) at rest. In the vagotomized group, the occlusion pressure responses to hypercapnia (ΔP0.2/ΔPaCO2) and hypoxia (ΔP0.2/ΔSaO2) in terms of response curve slope increased from 1.3 ± 1.2 to 1.9 ± 1.1 cm H2O/Torr and from 0.29 ± 0.19 to 0.88 ± 0.53 cm H2O/% (p < 0.05), respectively. Contrary to the vagotomized patients, the nonvagotomized control group exhibited no significant changes in ventilatory chemosensitivities. Furthermore, when comparing the control and vagotomized groups, postoperative ventilatory chemosensitivity responses in terms of both hypercapnic and hypoxic occlusion pressure responses were significantly higher in the latter. We suggest that (1) due to the development of the substantial mechanical limitation in pulmonary functions, the Hering-Breuer inflation reflex became activated after surgery, and (2) a diminished Hering-Breuer reflex effect to inhibit the respiratory centers by unilateral vagotomy may have resulted in augmented ventilatory chemosensitivities
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