Augmented asymmetrical visual field dependence in asymptomatic diabetics: Evidence of subclinical asymmetrical bilateral vestibular dysfunction

Razzak, Rima Abdul; Bagust, J.; Docherty, Sharon; Hussein, Wiam I.; Alotaibi, Abdullah M.

doi:10.1016/j.jdiacomp.2014.09.009

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…According to Cohen’s conventions [ 35 ], the effect size of glucose level on alignment errors was moderate in both frame conditions and large on the derived asymmetry index, however glucose levels in this study cannot predict, but may have some influence on verticality perception. These results are resonant to our previous study in which blood glucose levels in patients with diabetes portrayed a hyperglycemic range [ 15 ] and had a higher rate of larger alignment errors during visual conflict in comparison to euglycemic controls. For alignment errors, 26% of the diabetic participants exceeded a calculated top limit of 3.3 degrees from control group data, and almost 13% exceeded the maximal allowed value of 4 degrees.…”

Section: Discussionsupporting

confidence: 58%

“…Our interest in this cognitive ability relates to findings of a previous study investigating the effect of glycemic control on visual vertical (SVV) perception in elderly asymptomatic (without peripheral neuropathy or retinopathy) type 2 diabetic patients. Findings of that study indicated to decline in spatial perception ability during visual conflict in comparison to age-matched healthy controls, suggesting subclinical impairments of spatial orientation in patients with diabetes [ 15 ]. However, verticality perception in diabetics was not predicted by blood glucose levels or long term glycemic control (HbA 1c levels) in that study.…”

Section: Introductionmentioning

confidence: 99%

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High-normal blood glucose levels may be associated with decreased spatial perception in young healthy adults

et al. 2018

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The negative effects of high normal glucose on cognitive function were previously reported in euglycemic individuals of middle age and the elderly population. This study aimed at examining the effect of baseline blood glucose levels on spatial ability, specifically verticality perception on the computerized rod and frame test (CRFT) in young healthy adults. 63 healthy male medical students (age range from 18–23 years), of whom 30 were non-fasting outside the month of Ramadan and 33 fasting during Ramadan of the year 2016, were recruited in order to create varying degrees of glycemia during which verticality perception was carried out. Baseline blood glucose reading was obtained prior to commencing the CRFT test. Blood glucose levels at the time of testing decreased as the duration between the last meal and testing increased. A blood glucose range of 62–117 mg/dl was achieved among participants for this study. Linear regression analysis showed that blood glucose level at testing correlated positively with all alignment spatial error parameters, indicating a probable reduction of spatial perception ability with higher blood glucose levels. These results are consistent with other cognitive studies in older healthy humans and emphasize the critical impact of early glucose dys-homeostasis on cognitive function. They also indicate that elevated blood glucose may affect cognitive functioning outside of the usual complications of diabetes.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

High-normal blood glucose levels may be associated with decreased spatial perception in young healthy adults

et al. 2018

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“…There are two tools that are commonly used to measure the visual perception of verticality: The subjective visual vertical test (SVV) and the rod and frame test (RFT). Different studies looking into perception of visual verticality have revealed that it is impaired in neurological disorders such as stroke [ 73 , 74 , 75 ], Parkinson’s disease [ 76 , 77 ], multiple sclerosis [ 78 ], vestibular dysfunctions [ 79 , 80 , 81 ], chronic dizziness [ 82 ], and type II diabetes mellitus [ 83 ], among others.…”

Section: Discussionmentioning

confidence: 99%

Visual Verticality Perception in Spinal Diseases: A Systematic Review and Meta-Analysis

Obrero‐Gaitán

Molina

Casado

et al. 2020

JCM

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Patients diagnosed with traumatic or non-traumatic spinal pain and idiopathic scoliosis frequently suffer from imbalance. The evaluation of the perception of verticality by means of visual tests emerges as a quick and easy tool for clinical management of the balance disorders. Several studies have assessed the visual perception of verticality in spinal diseases obtaining controversial results. The aim of our study is to analyze the perception of visual verticality in subjects with several spinal diseases in comparison with healthy subjects. A meta-analysis was carried out. PubMed MEDLINE, Scopus, WoS, CINAHL, and SciELO databases were searched until January 2020. The standardized mean difference (SMD) was calculated to analyze differences between patients and healthy controls. Fifteen studies with a total of 2052 patients were included. In comparison with healthy subjects, a misperception of verticality was found in patients with spinal pain when the perception of the verticality was assessed with the rod and frame test (SMD = 0.339; 95% confidence interval (CI) = 0.181, 0.497; p < 0.001). It seems that the perception of visual verticality is not altered in patients with idiopathic scoliosis (p = 0.294). The present meta-analysis shows a misperception of visual verticality only in patients with spinal pain.

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“…It may have been preferable to include serial Rod and Frame testing sessions in the same participants, however, this was not carried out due to the vulnerability of the RFT to learning and practice effects, as alignment errors can be significantly decreased by only one retest (Noriaki, 1965). Then again, the computerized RFT has been used in many studies and shown to be sensitive enough to detect differences between control groups and other groups with different conditions, such as chronic neck pain (Docherty et al, 2012), diabetes mellitus (Abdul Razzak et al, 2015), or even between genders (Abdul Razzak et al, 2014). So the failure to detect any fasting effects is most likely due to its nonexistence, rather than the test's failure to detect them.…”

Section: Limitations and Conclusionmentioning

confidence: 99%

Is spatial orientation affected by Ramadan fasting?

Razzak¹,

Mohamed²,

Alshaiji³

et al. 2019

NFS

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1 Abstract Purpose-Ramadan intermittent fasting (RIF) has produced heterogeneous and domain-specific effects on cognitive function. The present study investigates the effect of RIF on verticality perception or estimation of subjective visual vertical (SVV) in young adults. The significance of SVV is that it is essential for spatial orientation, upon which many daily activities depend.Methodology -Verticality perception was assessed with a computerized version of the Rod and Frame Test (CRFT) in two visual conditions: without a surrounding frame, and with a distracting tilted frame. The tilted frame condition measures level of visual dependence, or reliance of visual cues for posture and orientation. 39 young adult male males were recruited at different stages of Ramadan fasting: 21 were tested at the end of the first week (Week 1) and 18 others at the end of the third week (Week 3) of Ramadan. 39 participants were also recruited to serve as a non-fasting control group. Factorial ANOVA analyses were conducted to identify the main effects of fasting status, time-of-day and the interaction between them on blood glucose levels, nocturnal sleep duration and vertical alignment errors. Findings-The main effect of fasting status on glucose level was significant (P = 0.03). There was a significant time-of-day main effect on glucose levels (P = 0.007) and sleep duration (P = 0.004) only in fasting participants. Neither the main effects of fasting status nor time-of-day were significant for rod alignment errors in both visual conditions. The interaction of fasting status and time-of-day was not significant either. This may indicate that any negative effect of Ramadan fasting on activities that are critically dependent on verticality perception and spatial orientation, such as sports and driving, may not be due to verticality misperception.Originality-The present study was the first to investigate the effect of Ramadan fasting on spatial orientation. It demonstrated robustness of verticality perception to fasting status and the point of fasting during Ramadan. Verticality perception was also unaffected by time of day effects in nonfasting and fasting groups at two different points of Ramadan. This study corroborates others reporting heterogeneous effects of Ramadan fasting on cognitive function.

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Augmented asymmetrical visual field dependence in asymptomatic diabetics: Evidence of subclinical asymmetrical bilateral vestibular dysfunction

Cited by 9 publications

References 26 publications

High-normal blood glucose levels may be associated with decreased spatial perception in young healthy adults

High-normal blood glucose levels may be associated with decreased spatial perception in young healthy adults

Visual Verticality Perception in Spinal Diseases: A Systematic Review and Meta-Analysis

Is spatial orientation affected by Ramadan fasting?

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