High-normal blood glucose levels may be associated with decreased spatial perception in young healthy adults

Razzak, Rima Abdul; Alshaiji, Abdulla Faisal; Qareeballa, Abdulrahman; Mohamed, Mohamed Wael; Bagust, J.; Docherty, Sharon

doi:10.1371/journal.pone.0199051

Cited by 11 publications

(4 citation statements)

References 36 publications

(43 reference statements)

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“…The Raman signatures were affected only during sensing thus selectively responding to the glucose biological event, not influenced by other components in the electrolyte. The structural probe exhibited good sensitivity of glucose detection for physiologically relevant applications (glucose levels within blood samples range between 4 and 22 mM; Li et al, ; Razzak et al, ). Taking into consideration the prospect of miniaturized Raman spectrometers (Gnyba, Smulko, Kwiatkowski, & Wierzba, ; Jiang, Yang, Meng, Jiang, & Zhan, ), the structural probe could be easier implemented into real‐world biosensing applications.…”

Section: Resultsmentioning

confidence: 99%

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

Pappa²,

Pitsalidis³

et al. 2019

Biotech & Bioengineering

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A large amount of research within organic biosensors is dominated by organic electrochemical transistors (OECTs) that use conducting polymers such as poly(3,4‐ethylene dioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS). Despite the recent advances in OECT‐based biosensors, the sensing is solely reliant on the amperometric detection of the bioanalytes. This is typically accompanied by large undesirable parasitic electrical signals from the electroactive components in the electrolyte. Herein, we present the use of in situ resonance Raman spectroscopy to probe subtle molecular structural changes of PEDOT:PSS associated with its doping level. We demonstrate how such doping level changes of PEDOT:PSS can be used, for the first time, on operational OECTs for sensitive and selective metabolite sensing while simultaneously performing amperometric detection of the analyte. We test the sensitivity by molecularly sensing a lowest glucose concentration of 0.02 mM in phosphate‐buffered saline solution. By changing the electrolyte to cell culture media, the selectivity of in situ resonance Raman spectroscopy is emphasized as it remains unaffected by other electroactive components in the electrolyte. The application of this molecular structural probe highlights the importance of developing biosensing probes that benefit from high sensitivity of the material's structural and electrical properties while being complimentary with the electronic methods of detection.

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Section: Resultsmentioning

confidence: 99%

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

Pappa²,

Pitsalidis³

et al. 2019

Biotech & Bioengineering

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“…Razzak et al [58] aimed at examining the effect of baseline blood glucose levels on spatial ability, specifically verticality perception on the computerized rod and frame test (CRFT) in young healthy adults. 63 healthy male medical students (age range from 18 to 23 years), of whom 30 were nonfasting outside the month of Ramadan and 33 fasting during Ramadan of the year 2016, were recruited to create varying degrees of glycemia during which verticality perception was carried out.…”

Section: Neurology and Psychologymentioning

confidence: 99%

The Year in “Ramadan Fasting and Health” (2018): A Narrative Review

Beshyah

Badi²,

Elghul

et al. 2019

Ibnosina Journal of Medicine and Biomedical Sciences

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Invited Review introduCtionRamadan fasting (RF) is practiced by adult Muslims during the 9 th lunar month every year. It entails that they abstain from eating and drinking between dawn and sunset. Medical and religious scholars got closer in their approach to advice given to patients based on objective risk assessment. [1] Muslim patients with acute or chronic medical conditions may be exempted from fasting; many do still choose to observe the fast sometimes against medical advice. This may adversely affect their health if not addressed properly by evidence-based recommendations. [2] There has been a tremendous recent interest in the health implications of RF. Keeping up with developments in this area may prove difficult, and hence, a narrative overview under a single cover may be particularly useful in presenting a digest of the research and expert opinion in the year. [3] Our previous review of the literature published in 2017 was the most viewed Introduction: There has been an increased interest in health implications of Ramadan fasting (RF). Materials and Methods: This is a narrative, nonsystematic review of the literature including all relevant full articles in English in three electronic databases (Scopus, PubMed, and Google Scholar). The search term "Ramadan fasting" was used to identify the relevant records to provide a readily comprehensible concise account of the contributions made to research and clinical practice in 1 year (2018). Results: The publications spanned basic, clinical, ethical, professional, and cultural and advocacy facets of the subject. The publications crossed the conventional disciplinary lines and geographical locations and appeared in journals with varying systems of access. Only full-text research articles in English were reviewed. Review articles, news, note items, and correspondence were not included. No formal bibliometric analysis is presented. Emerging concepts are presented under the relevant subheading depending on the available literature. Impact of RF on diabetes control, pregnancy outcome and fetal life, and sports and athletes' well-being received somewhat more prominent coverage by research work published in 2018. Renovascular disease, and risk factors, posttransplant care, and some metabolic concerns for patients with hepatic, renal, and metabolic conditions were covered too. Patterns of use of emergency services during Ramadan and features of some specific medical emergencies were examined by some workers. Most interesting perhaps was the greater focus on documenting the perception, attitudes, and practices of both patients and healthcare professions regarding deciding and acting during Ramadan. Isolated research reports addressed subjects of wide nature from body composition and energy metabolism to smoking, law, music, and history. Conclusions: The volume of scholarly work on Ramadan fasting and health remains modest. Greater improvements in both quality and quantity of research on Ramadan are needed. Most studies indicate that Ramadan fasting is safe in mild and st...

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“…For the majority of healthy people, normal blood glucose levels are 4.0 to 5.4 mmol/L (72 to 99 mg/dL) fasting and up to 7.8 mmol/L (140 mg/dL) 2 hours after eating. For people with diabetes, blood glucose levels are 4 to 7 mmol/L before meals, and after meals up to 9 mmol/L for type 1 diabetics and up to 8.5 mmol/L for type 2 diabetics [51,52].…”

Section: Diabetes: a Deregulation Of Blood Glucose Levelsmentioning

confidence: 99%

Insight into continuous glucose monitoring: from medical basics to commercialized devices

et al. 2023

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According to the latest statistics, more than 537 million people around the world struggle with diabetes and its adverse consequences. As well as acute risks of hypo-or hyper-glycemia, long-term vascular complications may occur, including coronary heart disease or stroke, as well as diabetic nephropathy leading to end-stage disease, neuropathy or retinopathy. Therefore, there is an urgent need to improve diabetes management to reduce the risk of complications but also to improve patient's quality life. The impact of continuous glucose monitoring (CGM) is well recognized, in this regard. The current review aims at introducing the basic principles of glucose sensing, including electrochemical and optical detection, summarizing CGM technology, its requirements, advantages and disadvantages. The role of CGM systems in the clinical diagnostics/personal testing, difficulties in their utilization and recommendations are also discussed. In the end, challenges and prospects in future CGM systems are discussed and non-invasive, wearable glucose biosensors are introduced. Though the scope of this review is CGMs and provides information about medical issues and analytical principles, consideration of broader use will be critical in future if the right systems are to be selected for effective diabetes management.

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High-normal blood glucose levels may be associated with decreased spatial perception in young healthy adults

Cited by 11 publications

References 36 publications

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

A highly sensitive molecular structural probe applied to in situ biosensing of metabolites using PEDOT:PSS

The Year in “Ramadan Fasting and Health” (2018): A Narrative Review

Insight into continuous glucose monitoring: from medical basics to commercialized devices

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