Augmentation of T-cell immune responses and signal transduction proteins in oral cancer patients: potential for IL-2-mediated immunotherapy

Cheriyan, Vino T.; Thomas, Cessal; Balaram, Prabha

doi:10.1007/s00432-011-1012-2

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…It directly promotes the transcription of FoxP3 [ 28 , 29 ]. Moreover, IL-2 has been shown to augment TCR-ζ (CD247) expression in chronic inflammation [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

et al. 2015

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BackgroundInduction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects.MethodsThe mRNA levels of T cell-related genes associated with tolerance or rejection (CD247, GZMB, PRF1, FOXP3, MAN1A1, TCAIM, and TLR5) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor-based triple immunosuppression and induction with rabbit anti-thymocyte globulin (rATG, n = 24), basiliximab (n = 17), or without induction (no-induction, n = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis.ResultsrATG treatment caused an intense reduction in all T cell type population and natural killer (NK) cells within 7 days, then a slow increase and repopulation was observed. This was also noticed in the expression levels of CD247, FOXP3, GZMB, and PRF1. The basiliximab group exhibited higher CD247, GZMB, FOXP3 and TCAIM mRNA levels and regulatory T cell (Treg) counts than the no-induction group. The levels of MAN1A1 and TLR5 mRNA expressions were increased, whereas TCAIM decreased in the rATG group as compared with those in the no-induction group.ConclusionThe rATG induction therapy was associated with decreased T and NK cell-related transcript levels and with upregulation of two rejection-associated transcripts (MAN1A1 and TLR5) shortly after KTx. Basiliximab treatment was associated with increased absolute number of Treg cells, and increased level of FOXP3 and TCAIM expression.

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“…It directly promotes the transcription of FoxP3 [ 28 , 29 ]. Moreover, IL-2 has been shown to augment TCR-ζ (CD247) expression in chronic inflammation [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

et al. 2015

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“…None of our previous studies analyzed the impact of an altered methylation pattern of these genes obtained from pre-operative oral brushing samples on post-surgical clinical outcome. Recently, few studies from other authors demonstrated that genetic and epigenetic alterations of some genes of our 13-gene panel may play a role in OSCC prognosis, presence of metastasis and response to treatment [18,[21][22][23][24][25][26]. For example, Marsit et al, starting from a case series of 68 post-surgical Formalin Fixed Paraffin Embedded (FFPE) OSCC samples revealed that an altered methylation pattern of ZAP70 and GP1BB is associated with poor survival [18].…”

Section: Introductionmentioning

confidence: 99%

Pre-Operative Evaluation of DNA Methylation Profile in Oral Squamous Cell Carcinoma Can Predict Tumor Aggressive Potential

Gissi

Fabbri

Gabusi

et al. 2020

IJMS

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Background: Prognosis of oral squamous cell carcinoma (OSCC) is difficult to exactly assess on pre-operative biopsies. Since OSCC DNA methylation profile has proved to be a useful pre-operative diagnostic tool, the aim of the present study was to evaluate the prognostic impact of DNA methylation profile to discriminate OSCC with high and low aggressive potential. Methods: 36 OSCC cases underwent neoplastic cells collection by gentle brushing of the lesion, before performing a pre-operative biopsy. The CpG islands methylation status of 13 gene (ZAP70, ITGA4, KIF1A, PARP15, EPHX3, NTM, LRRTM1, FLI1, MiR193, LINC00599, MiR296, TERT, GP1BB) was studied by bisulfite Next Generation Sequencing (NGS). A Cox proportional hazards model via likelihood-based component-wise boosting was used to evaluate the prognostic power of the CpG sites. Results: The boosting estimation identified five CpGs with prognostic significance: EPHX3-24, EPHX3-26, ITGA4-3, ITGA4-4, and MiR193-3. The combination of significant CpGs provided promising results for adverse events prediction (Brier score = 0.080, C-index = 0.802 and AUC = 0.850). ITGA4 had a strong prognostic power in patients with early OSCC. Conclusions: These data confirm that the study of methylation profile provides new insights into the molecular mechanisms of OSCC and can allow a better OSCC prognostic stratification even before surgery.

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Lichen Planus

Bragazzi¹,

Nicolini²

2015

Genomics, Personalized Medicine and Oral Disease

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Augmentation of T-cell immune responses and signal transduction proteins in oral cancer patients: potential for IL-2-mediated immunotherapy

Cited by 7 publications

References 28 publications

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

Pre-Operative Evaluation of DNA Methylation Profile in Oral Squamous Cell Carcinoma Can Predict Tumor Aggressive Potential

Lichen Planus

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