Lichen Planus

Microarray-based Functional Nanoproteomics for an Industrial Approach to Cancer: I Bioinformatics and miRNAome

“…A unique combination of genomics and proteomics approaches can indeed represent a promising innovation for a unique personalized treatment of OLP and oral cancer [18]. This theoretical premise is unique for its potential clinical value, considering that the marginal (although significant) differences between randomly generated and experimentally validated miRNAs point to the critical importance of prospective validation in a patient cohort [19]. Assuming the prevalence rate reported in reference [2] in the range 1.27-1.57% and a precision of 5%, a minimum number of 20-24 patients, within the 95% confidence interval, is needed to validate our bioinformatics predictions.…”