Augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo.

Djeu, Julie Y.; Huang, Kaixing; Herberman, Ronald B.

doi:10.1084/jem.151.4.781

Cited by 72 publications

(19 citation statements)

References 14 publications

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“…High levels of IFNg at week 7 PI in the 'infection + glucan' group correlated with the highest foot pad thickness at this time indicating the maximum level of infection. Djeu et al [22] also proved that antigens like viruses, bacterial products, and tumor cells are able to induce interferon (IFN) from NK cells and IFN-mediated boosting of NK activity. This may be the cause for increase of NK activity in 'infection only' group as well with time of infection because parasitic antigens can induce the release of IFNs to boost the NK cell activity.…”

Section: Discussionmentioning

confidence: 99%

Aureobasidium-Derived Soluble Branched (1,3-1,6) β-Glucan (Sophy β-glucan) Enhances Natural Killer Activity in Leishmania amazonensis-Infected Mice

et al. 2009

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Abstract:The b-glucans derived from yeast cell walls have been reported for having many immunomodulatory activities in vivo and in vitro. In this study, Aureobasidium-derived soluble branched (1,3-1,6) b-glucan (Sophy b-glucan) was checked for natural killer (NK) activity and for the production of IFN-g and IL-4 in Leishmania amazonensis infection. The main experiment was performed with a group of female C57BL/6 and BALB/c mice, orally supplemented with 5% of Sophy b-glucan and infected with promastogotes of L. amazonensis (1 × 10 7 ) into the footpad. Increase in the footpad thickness with time was observed in BALB/c mice in spite of the oral Sophy b-glucan supplement, but it was less in C57BL/6 mice. The difference in overall mean footpad thickness between 'infection only' versus 'infection + glucan' groups was statistically significant (P < 0.001). High NK activity in C57BL/6 than BALB/c mice was observed in 'glucan only' group compared to the control group and also in 'infection + glucan' group compared to 'infection only' group. The difference in the NK activity among these groups was significant (P < 0.05). The IFN-g level increased at weeks 7 and 8 post-infection in C57BL/6 mice and was significantly high in 'infection + glucan' group compared to the 'infection only' group (P < 0.05). IL-4 levels did not increase up to detectable levels throughout the study. The results led a conclusion that Sophy b-glucan enhances NK activity and cellular immunity in L. amazonensis-infected mice.

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Section: Discussionmentioning

confidence: 99%

Aureobasidium-Derived Soluble Branched (1,3-1,6) β-Glucan (Sophy β-glucan) Enhances Natural Killer Activity in Leishmania amazonensis-Infected Mice

et al. 2009

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“…Therefore, one cannot rule out the possibility that inoculation of certain tumor cells into older or beige mice leads to rapid production of interferon with an increase in the cytotoxic activity of NK cells in vivo to the levels observed in young, normal mice. The YAC and R L 6 1 cell lines used here are able to induce in vivo augmentation of NK activity and interferon production (Djeu et al, 1980), but this probably would not occur rapidly enough to affect the results in the 4-h i.v.…”

Section: Discussionmentioning

confidence: 99%

Radioisotope assay for evaluation of in vivo natural cell‐mediated resistance of mice to local transplantation of tumor cells

Gorelik

Herberman

1981

Intl Journal of Cancer

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A radioisotopic assay based on the rate of elimination of ['lslldUrd-labelled (5) This adoptive transfer of the cytotoxicity was mediated by non-adherent, non-T cells that expressed asialo GMI. Despite these correlations between NK activity and the in vivo assay, two major discrepancies were found: YAC-I cells were eliminated at the same rate in young and old mice, and beige mice were as effective for in vivoclearance of tumor cells as were normal C57BU6 mice. These data suggested that other natural effector cells may participate in the in vivodestruction of the transplanted tumor cells or that different regulatory processes may operate in vivo. Our findings provide further evidence that natural cell-mediated immunity can play an important role in the in vivoelimination of the transplanted tumor cells and indicate that this CM occur at the local site of tumor inoculation as well as in the lungs or other organs.

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“…A rapid and high increase of natural killer (NK) activity has been demonstrated in mice inoculated with a variety of viruses [34], immunoadjuvants such as bacillus calmette-Guerin, (BCG) [36] or tumor cells [5].…”

Section: Introductionmentioning

confidence: 99%

Production of cytokines after lipopolysaccharide stimulation of murine spleen cells during lymphoma development in AKR mice

Vaillier

Daculsi

Legrand

et al. 1989

Cancer Immunol Immunother

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Injection of syngeneic lymphoma cells in AKR mice, resulted in an important increase of splenic natural killer (NK) activity in the early days following the graft. Modifications of the production of different types of cytokine: interferon, interleukins 1 and 2, tumor necrosis factor (IFN, IL-1, IL-2, TNF), involved in the regulation of NK activity, were investigated in short-term cultures of total, adherent and non-adherent fractionated spleen cells, using lipopolysaccharide as the triggering or amplifying agent. Upon stimulation with lipopolysaccharide, splenocytes from lymphoma-grafted mice released a large amount of interferon as compared to controls with a maximum level 1 day after the graft. Equal amounts of IFN-gamma and IFN-alpha/beta were detected. Treatment of spleen cells prior to culture with anti-(asialo-GM1) or anti-(Thy-1.1) antibodies reduced interferon production by 80% and 50% respectively. This finding indicates that (a) the IFN-gamma is produced by Thy-1-positive cells and (b) the production of IFN-gamma by these cells is at least partially under the control of asialo-GM1-positive cells. We also showed that non-adherent fractionated spleen cells from lymphoma-grafted mice produced IL-1 and IL-2. IL-1 was released by asialo-GM1-positive cells and IL-2 by Thy-1-positive cells. Adherent cells released only IL-1. In contrast, total cells released smaller amounts of IL-1 and IL-2, suggesting a reciprocal inhibition between subpopulations of non-adherent and adherent cells. A high level of TNF production by adherent cells was observed only 4 days after the graft. These results indicate that graft of lymphoma cells entails important modifications of spleen cell populations releasing different types of cytokines implicated in NK activation.

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Augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo.

Cited by 72 publications

References 14 publications

Aureobasidium-Derived Soluble Branched (1,3-1,6) β-Glucan (Sophy β-glucan) Enhances Natural Killer Activity in Leishmania amazonensis-Infected Mice

Aureobasidium-Derived Soluble Branched (1,3-1,6) β-Glucan (Sophy β-glucan) Enhances Natural Killer Activity in Leishmania amazonensis-Infected Mice

Radioisotope assay for evaluation of in vivo natural cell‐mediated resistance of mice to local transplantation of tumor cells

Production of cytokines after lipopolysaccharide stimulation of murine spleen cells during lymphoma development in AKR mice

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