Augmentation of Heme Oxygenase-1 Expression on the Graft Immediately After Implantation in Adult Living Donor Liver Transplantation

Transient Limb Ischemia Induces Remote Preconditioning in Liver among Rats: The Protective Role of Heme Oxygenase-1

“…It has been reported that increased expression were mainly in the Kupffer cells after living liver transplantation in adult recipients (37). However, the parenchymal cells also express HO-1 under stress (36,38).…”

Natural heme oxygenase-1 inducers in hepatobiliary function

“…In conclusion, HO-1 genotype is associated with outcome after liver transplantation, suggesting that HO-1 mediates graft survival after liver transplantation. Excessive shear stress secondary to portal hypertension is probably involved in the augmented HO-1 expression in small-forsize graft liver [53] . In this model, recombinant Ad-HO-1 administered to donors 48 h before transplantation enhances HO-1 expression in both whole and small-forsize allografts, with a predominant augmentation in the small-for-size allografts, suggesting favorable conditions for the induction of HO-1 expression in small-for-size allografts.…”

Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspases

“…The HSP heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the heme degradation pathway (13) induced by inflammatory cytokines, oxidation, ischemia, hypoxia and endotoxins (14). HO-1 is a highly conserved stress protein that has been shown to act in a non-selective manner to confer protection to normal and cancerous organs, tissues and cells against harmful stimuli and pathological processes (15). The lack of selectivity of the protective function associated with HO-1 may result in tumor resistance to chemotherapeutic drugs (16 we demonstrated that HO-1 can protect CML cells from apoptosis, and that an association exists between HO-1 and CML cell growth (17).…”