Natural heme oxygenase-1 inducers in hepatobiliary function

Volti, Giovanni Li; Sacerdoti, David; Giacomo, Claudia Di; Barcellona, Maria Luisa; Scacco, Antonio; Murabito, Paolo; Biondi, Antonio; Burzotta, Francesco; Gazzolo, Diego; Abella, Raúl; Frigiola, Alessandro; Galvano, Fabio

doi:10.3748/wjg.14.6122

Cited by 43 publications

(25 citation statements)

References 75 publications

(77 reference statements)

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“…Normally, HO-l is expressed constitutively in Kuppfer cells, and HO-l induction in the human liver protects hepatocytes from EtOH-induced cytotoxicity. Li Volti et al (26) described the therapeutic effects of natural antioxidant compounds that modulate HO-l expression. The current results suggest that EAAem supplementation may have similar effects.…”

Section: G-i) Grp-75 Immunohistochemistry (Counterstained With Hematomentioning

confidence: 99%

Essential Amino Acid Supplementation Decreases Liver Damage Induced by Chronic Ethanol Consumption in Rats

Corsetti

Stacchiotti

Tedesco

et al. 2011

Int J Immunopathol Pharmacol

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The first two authors contributed equally to the work The liver sustains the greatest damage from ethanol (EtOH) abuse. EtOH and its metabolites impair hepatocyte metabolism, causing intracellular accumulation of proteins and lipids and increasing radical oxygen species production. These processes are toxic to the mitochondrial respiratory chain and to mitochondrial DNA. We have recently shown that supplementating the diet of rodents with an essential amino acid-enriched mixture (EAAem) significantly increases mitochondrial mass and number in cardiac and skeletal muscles and improves mitochondrial function in aged animals. Thus, in this study we sought to test whether EAAem supplementation could reduce EtOH-induced liver damage. Groups of adult male Wistar rats were fed a standard diet and water ad libitum (the control group), drinking water with 20% EtOH (the EtOH group), or drinking water with 20% EtOH and EAAem supplementation (1.5 g/kg/day) (the EtOH+EAAem group) for 2 months. The blood EtOH concentration was measured, and markers for fat (Oil-Red-O), mitochondria (Grp75, Cyt-c-ox), endoplasmic reticulum (Grp78), and inflammation (Heme Oxigenase 1, iNOS, and peroxisomes) were analyzed in the liver of animals in the various experimental groups. EAAem supplementation in EtOH-drinking rats ameliorated EtOHinduced changes in liver structure by limiting steatosis, recruiting more mitochondria and peroxisomes mainly to perivenous hepatocytes, stimulating or restoring antioxidant markers, limiting the expression of inflammatory processes, and reducing ER stress. Taken together, these results suggest that EAAem supplementation may represent a promising strategy to prevent and treat EtOH-induced liver damage.The liver is the major site of ethanol (EtOH) metabolism and thus sustains the most injury from chronic EtOH consumption. Indeed, alcoholrelated liver disease (ALD) is the second leading cause of death among alI liver disorders (I). ALD is a colIective term for the pathophysiological changes caused by chronic EtOH consumption, which include progressive liver damage due to

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Section: G-i) Grp-75 Immunohistochemistry (Counterstained With Hematomentioning

confidence: 99%

Essential Amino Acid Supplementation Decreases Liver Damage Induced by Chronic Ethanol Consumption in Rats

Corsetti

Stacchiotti

Tedesco

et al. 2011

Int J Immunopathol Pharmacol

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“…A number of natural phytocompounds have been shown to be effective non‐stressful and non‐cytotoxic inducers of HO‐1 (Li Volti et al . ). Some polyphenols, such as curcumin, caffeic acid phenethyl ester, and resveratrol, can act as HO‐1 inducers and their abilities to induce HO‐1 are consistent with their anti‐inflammatory properties (Motawi et al .…”

Section: Discussionmentioning

confidence: 97%

Amomum tsao‐ko fruit extract suppresses lipopolysaccharide‐induced inducible nitric oxide synthase by inducing heme oxygenase‐1 in macrophages and in septic mice

Shin

Ryu

Jang

et al. 2015

Int J Experimental Path

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Amomum tsao-ko Crevost et Lemarié (Zingiberaceae) has traditionally been used to treat inflammatory and infectious diseases, such as throat infections, malaria, abdominal pain and diarrhoea. This study was designed to assess the anti-inflammatory effects and the molecular mechanisms of the methanol extract of A. tsao-ko (AOM) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and in a murine model of sepsis. In LPS-induced RAW 264.7 macrophages, AOM reduced the production of nitric oxide (NO) by inhibiting inducible nitric oxide synthase (iNOS) expression, and increased heme oxygenase-1 (HO-1) expression at the protein and mRNA levels. Pretreatment with SnPP (a selective inhibitor of HO-1) and silencing HO-1 using siRNA prevented the AOM-mediated inhibition of NO production and iNOS expression. Furthermore, AOM increased the expression and nuclear accumulation of NF-E2-related factor 2 (Nrf2), which enhanced Nrf2 binding to antioxidant response element (ARE). In addition, AOM induced the phosphorylation of extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) and generated reactive oxygen species (ROS). Furthermore, pretreatment with N-acetyl-l-cysteine (NAC; a ROS scavenger) diminished the AOM-induced phosphorylation of ERK and JNK and AOM-induced HO-1 expression, suggesting that ERK and JNK are downstream mediators of ROS during the AOM-induced signalling of HO-1 expression. In LPS-induced endotoxaemic mice, pretreatment with AOM reduced NO serum levels and liver iNOS expression and increased HO-1 expression and survival rates. These results indicate that AOM strongly inhibits LPS-induced NO production by activating the ROS/MAPKs/Nrf2-mediated HO-1 signalling pathway, and supports its pharmacological effects on inflammatory diseases.

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“…Specifically, those afflicted with chronic lung conditions and some form of a psychiatric disorder tend to show patterns of worse symptoms and greater functional impairment than those without [106]. Given the current lack of systematic reviews regarding the impact of mental health symptoms on clinical disease outcomes Resveratrol is an antidiabetic agent that modulates SIRT1, thereby improving glucose homeostasis and inhibiting diabetic neuropathy [73][74][75][76] Quercetin is protective against oxidative stress and lipid peroxidation [77] Ferulic acid has shown to reduce blood glucose levels [78,79] (−)-Epigallocatechin 3-O-gallate regulates glucose homeostasis and decreases renal advanced glycation end products (AGEs) accumulation and proteinuria (common in diabetic nephropathy) [80] Suppression of hyperglycemia, AGEs, and related oxidative stress and cytokine activations by various polyphenols [80] Attenuation of diabetic cataracts, retinopathy, hyperlipidemia, oxidative stress, and increase in insulin sensitivity with green tea polyphenols [81] HEPATOBILIARY DISEASE Fibrosis, cholestasis, chlolithiasis, cirrhosis, portal hypertension, liver failure Curcumin, quercetin Natural inducers of heme oxygenase-1, a stress response enzyme induced as a protective mechanism for protection against inflammatory processes, oxidative tissue damage, and induction of liver regeneration [82] Quercetin prevents ethanol toxicity in human hepatocytes through p38 and ERK/Nrf2 transduction pathway [82][83][84] …”

Section: Cf-related Mental Impairmentsmentioning

confidence: 99%

The Emergence of Polyphenols in the Potentiation of Treatment Modality in Cystic Fibrosis

Kubow

Fung

Naqvi

et al. 2015

Diet and Exercise in Cystic Fibrosis

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Natural heme oxygenase-1 inducers in hepatobiliary function

Cited by 43 publications

References 75 publications

Essential Amino Acid Supplementation Decreases Liver Damage Induced by Chronic Ethanol Consumption in Rats

Essential Amino Acid Supplementation Decreases Liver Damage Induced by Chronic Ethanol Consumption in Rats

Amomum tsao‐ko fruit extract suppresses lipopolysaccharide‐induced inducible nitric oxide synthase by inducing heme oxygenase‐1 in macrophages and in septic mice

The Emergence of Polyphenols in the Potentiation of Treatment Modality in Cystic Fibrosis

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