2001
DOI: 10.1002/1521-3757(20010903)113:17<3212::aid-ange3212>3.0.co;2-t
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Aufspüren eines Paradigmenwechsels auf dem Gebiet der molekularen Erkennung: von den selektiven Rezeptoren zu den differenziellen Rezeptoren

Abstract: Das Gebiet der molekularen Erkennung hat ein Stadium erreicht, an dem relativ zielsicher Rezeptoren, die ein hohes Maû an Vorhersagbarkeit und gute Selektivitätseigenschaften gegenüber vielen kleinen und mittelgroûen Molekülen haben, entworfen und synthetisiert werden können. Der Antrieb dieses Ziel zu erreichen, lag vorwiegend darin, die auûergewöhnlich spezifischen bindenden Wechselwirkungen der Natur zu verstehen und nachzuahmen, die exemplarisch in der Schlüssel-Schloss-Analogie zum Ausdruck kommen (Abbild… Show more

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Cited by 91 publications
(23 citation statements)
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References 132 publications
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“…[21] Despite the successful use of some of these sensors in various applications, artificial electronic noses and tongues often lack selectivity and sensitivity compared with the original biological systems, in which recognition and amplification is based on structure-dependent binding to the receptor as a result of specific molecular recognition. [22,23] To benefit from the high sensitivity of the olfactory system, olfactory receptor cells have been directly attached to the surface of suitable sensor chips. [24] Nevertheless, the reproducibility of the measurements and the lifetime of the biosensors still need improvement to build highly performing and robust devices.…”
Section: Sensing Mixtures Of Volatile Compoundsmentioning
confidence: 99%
See 1 more Smart Citation
“…[21] Despite the successful use of some of these sensors in various applications, artificial electronic noses and tongues often lack selectivity and sensitivity compared with the original biological systems, in which recognition and amplification is based on structure-dependent binding to the receptor as a result of specific molecular recognition. [22,23] To benefit from the high sensitivity of the olfactory system, olfactory receptor cells have been directly attached to the surface of suitable sensor chips. [24] Nevertheless, the reproducibility of the measurements and the lifetime of the biosensors still need improvement to build highly performing and robust devices.…”
Section: Sensing Mixtures Of Volatile Compoundsmentioning
confidence: 99%
“…Sensors based on differential pattern recognition using synthetic molecular receptors generated as combinatorial libraries have recently been described as a further step to mimic human olfaction. [23] In contrast to highly selective binding to a specific receptor, differential pattern recognition uses non-specific interactions by simultaneously responding to different receptors in an array, but to different degrees. [23] Sensing based on reversible DCC: The recent development of DCC [5][6][7][8][9][10] based on the reversible formation of covalent bonds [25] brings new aspects to the research on compound mixtures.…”
Section: Sensing Mixtures Of Volatile Compoundsmentioning
confidence: 99%
“…Often, anion recognition [237][238][239][240][241][242] is more difficult to achieve with a controlled relative geometry of host and guest so that it may be more challenging to design a threaded host-guest complex based on anions. This may be the reason, why the anion templates for the formation of catenanes or rotaxanes are limited in number and have been used less often than those based on cation recognition.…”
Section: Anion-templated Synthesis Of Rotaxanes and Their Structural mentioning
confidence: 99%
“…[11] In particular, sensor arrays are a verified valid detection method in the area of multi-analyte testing and high-throughput analysis. [12] Generally, array sensing needs large numbers of serial compounds as sensors to perform the correlative differential analysis. It involves complicated chemical synthesis and valid compound screening.…”
mentioning
confidence: 99%
“…[12] Generally, array sensing needs large numbers of serial compounds as sensors to perform the correlative differential analysis. Although many serial sensors have been designed and synthesized, [12][13][14] it is still a challenge to achieve multi-testing sensor array conveniently and develop general and high-performance multi-analyte detection methods. Although many serial sensors have been designed and synthesized, [12][13][14] it is still a challenge to achieve multi-testing sensor array conveniently and develop general and high-performance multi-analyte detection methods.…”
mentioning
confidence: 99%