A Multi‐stopband Photonic‐Crystal Microchip for High‐Performance Metal‐Ion Recognition Based on Fluorescent Detection

Huang, Yu; Li, Fengyu; Qin, Meng; Jiang, Lei; Song, Yanlin

doi:10.1002/anie.201302311

Cited by 152 publications

(117 citation statements)

References 51 publications

(16 reference statements)

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“…PhCs are a kind of well-known photonic nanomaterial with spatially ordered lattices that exhibit brilliant structural colors. [75][76][77][78][79][80][81][82][83] Because of the periodic arrangement of the dielectric materials, an amazing property known as the photonic band gap (PBG) appears. This leads to the light that with certain wavelengths or frequencies located in the PBG being prohibited from propagating through the PhCs.…”

Section: Phc Barcodes From Single Emulsionsmentioning

confidence: 99%

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

Zhao

Cheng

Shang

et al. 2014

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The increasing use of high-throughput assays in biomedical applications, including drug discovery and clinical diagnostics, demands effective strategies for multiplexing. One promising strategy is the use of barcode particles that encode information about their specific compositions and enable simple identification. Various encoding mechanisms, including spectroscopic, graphical, electronic, and physical encoding, have been proposed for the provision of sufficient identification codes for the barcode particles. These particles are synthesized in various ways. Microfluidics is an effective approach that has created exciting avenues of scientific research in barcode particle synthesis. The resultant particles have found important application in the detection of multiple biological species as they have properties of high flexibility, fast reaction times, less reagent consumption, and good repeatability. In this paper, research progress in the microfluidic synthesis of barcode particles for multiplex assays is discussed. After introducing the general developing strategies of the barcode particles, the focus is on studies of microfluidics, including their design, fabrication, and application in the generation of barcode particles. Applications of the achieved barcode particles in multiplex assays will be described and emphasized. The prospects for future development of these barcode particles are also presented.

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Section: Phc Barcodes From Single Emulsionsmentioning

confidence: 99%

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

Zhao

Cheng

Shang

et al. 2014

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189

139

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“…This multi-stopbands PC-chip performs a highly effi cient multi-targets discrimination for twelve metal ions based on only one simple sensor. [ 98 ] The PC microchip was easily fabricated by hydrophilic colloidal particle self-driven deposition on the hydrophilic areas of a hydrophilic-hydrophobic patterned substrate from lithography. As shown in Figure 4 a, fi rstly, hydrophobic CH 3 (CH 2 ) 17 PO 3 H 2 was the self-assembly monolayer (SAM) on glass substrate.…”

Section: Photolithography For Sensing Arraysmentioning

confidence: 99%

Printable Functional Chips Based on Nanoparticle Assembly

Huang

Qin

et al. 2016

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With facile manufacturability and modifiability, impressive nanoparticles (NPs) assembly applications were performed for functional patterned devices, which have attracted booming research attention due to their increasing applications in high-performance optical/electrical devices for sensing, electronics, displays, and catalysis. By virtue of easy and direct fabrication to desired patterns, high throughput, and low cost, NPs assembly printing is one of the most promising candidates for the manufacturing of functional micro-chips. In this review, an overview of the fabrications and applications of NPs patterned assembly by printing methods, including inkjet printing, lithography, imprinting, and extended printing techniques is presented. The assembly processes and mechanisms on various substrates with distinct wettabilities are deeply discussed and summarized. Via manipulating the droplet three phase contact line (TCL) pinning or slipping, the NPs contracted in ink are controllably assembled following the TCL, and generate novel functional chips and correlative integrate devices. Finally, the perspective of future developments and challenges is presented and widely exhibited.

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“…Although aP Cc hip with multiple stop bands could achieve successful multianalysis with asimple dye, [9] the fabrication and integration of multiplex PC materials matrix still remains ac omplex process. As ac lass of periodic structured materials,P Cs can control the propagation of light, which is characterized by an angle dependence.…”

mentioning

confidence: 99%

A Rainbow Structural‐Color Chip for Multisaccharide Recognition

Qin

Huang

et al. 2016

Angewandte Chemie

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Acritical requirement for the successful recognition of multiple analytes is the acquisition of abundant sensing information. However,for this to be achieved requires massive chemical sensors or multiplex materials,whichcomplicates the multianalysis.Thus,there is aneed to develop astrategy for the facile and efficient recognition of multiple analytes.Herein, we explore the angle-dependent structural colors of photonic crystals to provide abundant optical information, thereby generating ar ainbow-color chip to realize the convenient recognition of multiple analytes.Bysimply using amultiangle analysis method, the monophotonic crystal matrix chip can differentially enhance fluorescence signals over broad spectral ranges,t herebyr esulting in abundant sensing information for highly efficient multiple analysis.T welve saccharides with similar structures,a sw ell as saccharides in different concentrations and mixtures,were successfully discriminated.The recognition of multiple analytes has drawn increased attention in the areas of clinical diagnosis, [1] biological screening, [2] thef ood industry, [3] vapor monitoring, [4] etc. A critical requirement for successful multiple recognition is the acquisition of abundant sensing information. In general, large numbers of sensing molecules or indicators have to be employed to attain sufficient sensing information, but this always involves complicated synthesis or massive screening programs.[5] Selective signal enhancement by physical methods could provide an opportunity for increased sensing information to achieve facile and efficient recognition of multiple analytes,w ithout the need for large numbers of chemical compounds.P hotonic crystals (PCs) have been widely employed to facilitate the area of detection, mainly through structural colors, [6] reflectance, [7] and fluorescence enhancement [8] induced by the unique photonic stop bands, which endow the platform with the desired abundant optical information. Although aP Cc hip with multiple stop bands could achieve successful multianalysis with asimple dye, [9] the fabrication and integration of multiplex PC materials matrix still remains ac omplex process. As ac lass of periodic structured materials,P Cs can control the propagation of light, which is characterized by an angle dependence.[10] APCmatrix with along-range-ordered structure can exhibit structural colors in consecutive spectra, reminiscent of ar ainbow seen in nature.A ss hown in Figure 1a,aPC matrix film assembled from poly(styrene/ methyl methacrylate/acrylic acid) [poly(St-MMA-AA)] latex particles with diameter of 270 nm exhibits as trong red color when illuminated with white light at normal incidence.When the film is rotated, which causes as imultaneous increase in the incident angle and reflection angle from 08 8 to 808 8,t he color changes from red to orange and finally to bluish violet. Thus,w ith various detection angles (referred to as the reflection angles,w hich are equal to the incident angles), as ingle PC matrix can serve as ap latform to...

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A Multi‐stopband Photonic‐Crystal Microchip for High‐Performance Metal‐Ion Recognition Based on Fluorescent Detection

Cited by 152 publications

References 51 publications

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

Printable Functional Chips Based on Nanoparticle Assembly

A Rainbow Structural‐Color Chip for Multisaccharide Recognition

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