Auditory target processing in methadone substituted opiate addicts: The effect of nicotine in controls

Müller, Bernhard; Specka, Michael; Steinchen, Nicolai; Zerbin, Dieter; Lodemann, E.; Finkbeiner, Thomas; Scherbaum, Norbert

doi:10.1186/1471-244x-7-63

Cited by 14 publications

(17 citation statements)

References 36 publications

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“…This implies, that a paradigm or task is employed that can robustly elicit certain brain regions or more integrated functional circuits [e.g. [60][61][62]64]. Such paradigms can be cognitive tasks, but also more passive conditions such as the oddball paradigm [e.g.…”

Section: Fmri To Study Acute Pharmacological Effectsmentioning

confidence: 99%

Independent Component Analysis Applied to Pharmacological Magnetic Resonance Imaging (phMRI): New Insights Into the Functional Networks Underlying Panic Attacks as Induced by CCK-4

Dieler¹,

Sämann²,

Leicht³

et al. 2008

CPD

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Pharmacological magnetic resonance imaging (phMRI) is a method to study effects of psychopharmacological agents on neural activation. Changes of the blood oxygen level dependent (BOLD), the basis of functional MRI (fMRI), are typically obtained at relatively high sampling frequencies. This has more recently been exploited in the field of fMRI by applying independent component analysis (ICA), an explorative data analysis method decomposing activation into distinct neural networks. While already successfully used to investigate resting network and task-induced activity, its use in phMRI is new. Further extension of this method to tensorial probabilistic ICA (tensor PICA) allows to group similar brain activation across the anatomical, temporal, subject or session domain. This approach is useful for pharmacological experiments when no pharmacokinetic model exists. We exemplify this method using data from a placebo-controlled cholecystokinine-4 (CCK-4) injection experiment performed on 16 neuropsychiatrically and medically healthy males (age 25.6 +/- 4.2 years). Tensor PICA identified strong increases in activity in 12 networks. Comparison with results gained from the standard approach (voxelwise regression analysis) revealed good reproduction of areas previously associated with CCK-4 action, such as the anterior cingulate, orbitofrontal cortex, cerebellum, temporolateral, left parietal and insular areas, striatum, and precuneus. Several other components such as the dorsal anterior cingulate and medial prefrontal cortex were identified, suggesting higher sensitivity of the method. Exploration of the time courses of each activated network revealed differences, that might be lost when a fixed time course is modeled, e. g. neuronal responses to an acoustic warning signal prior to injection. Comparison of placebo and CCK-4 runs further showed that a proportion of networks are newly elicited by CCK-4 whereas other components are significantly active in the placebo conditions but further enhanced by CCK-4. In conclusion, group ICA is a promising tool for phMRI studies that allows quantifying and visualizing the modulation of neural networks by pharmacological interventions.

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Section: Fmri To Study Acute Pharmacological Effectsmentioning

confidence: 99%

Independent Component Analysis Applied to Pharmacological Magnetic Resonance Imaging (phMRI): New Insights Into the Functional Networks Underlying Panic Attacks as Induced by CCK-4

Dieler¹,

Sämann²,

Leicht³

et al. 2008

CPD

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“…Because it has been shown that nicotine can also affect the CNS of humans, in a novel study Muller et al () investigated the effect of nicotine on the P300 component among MMT subjects and found a decline in P300 amplitude among nicotine dependents (Muller et al, ). It was also suggested that target attentional processing disability can be reorganized for MMT subjects; however, a significant result of this study showed that the effects of nicotine on P300 amplitude among healthy subjects exceeds the effects of MMT on heroin dependents.…”

Section: Brain Electrophysiological Findingsmentioning

confidence: 99%

“…ERPs consist of time-locked components related to information processing operations that provide a reliable approach for studying brain-behavior relations, information processing, and cognitive biases (Boutros et al, 1997;Handy, 2005). Standard ERP investigations include three types of paradigms (Table II): 1) oddball paradigms (standard and target stimuli) during resting conditions (Bauer, 2001;Kivisaari et al, 2007;Muller et al, 2007;Singh et al, 2009) or during the exposure of various emotional targeting slides (Marques-Teixeira and Barbosa, 2005), 2) visual Go-No Go paradigms that use neutral or emotional conditions (Yang et al, 2009;Morie et al, 2014), and 3) the standard digit span Wechsler test paradigm (Papageorgiou et al, 2001(Papageorgiou et al, , 2003(Papageorgiou et al, , 2004Kalatzis et al, 2005).…”

Section: Standard Erp Paradigmsmentioning

confidence: 99%

Neuroelectrophysiological approaches in heroin addiction research: A review of literatures

Motlagh

Ibrahim

Menke

et al. 2016

J of Neuroscience Research

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Neuroelectrophysiological properties have been used in human heroin addiction studies. These studies vary in their approach, experimental conditions, paradigms, and outcomes. However, it is essential to integrate previous findings and experimental methods for a better demonstration of current issues and challenges in designing such studies. This Review examines methodologies and experimental conditions of neuroelectrophysiological research among heroin addicts during withdrawal, abstinence, and methadone maintenance treatment and presents the findings. The results show decrements in attentional processing and dysfunctions in brain response inhibition as well as brain activity abnormalities induced by chronic heroin abuse. Chronic heroin addiction causes increased β and α2 power activity, latency of P300 and P600, and diminished P300 and P600 amplitude. Findings confirm that electroencephalography (EEG) band power and coherence are associated with craving indices and heroin abuse history. First symptoms of withdrawal can be seen in high-frequency EEG bands, and the severity of these symptoms is associated with brain functional connectivity. EEG spectral changes and event-related potential (ERP) properties have been shown to be associated with abstinence length and tend to normalize within 3-6 months of abstinence. From the conflicting criteria and confounding effects in neuroelectrophysiological studies, the authors suggest a comprehensive longitudinal study with a multimethod approach for monitoring EEG and ERP attributes of heroin addicts from early stages of withdrawal until long-term abstinence to control the confounding effects, such as nicotine abuse and other comorbid and premorbid conditions.

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“…Some studies reported changes in P300 amplitude and latency in cases of chronic consumption of nicotine, alcohol, as well as cannabis, opioids, cocaine, and ecstasy (Table 2) (8,(54)(55)(56)(57)(58)(59)(60).…”

Section: Review Of Literaturementioning

confidence: 99%

“…ERP components such as auditory evoked P300, associated with cognitive processes (i.e., attention and orientation), show low amplitude and long latency in acute and chronic diseases (4)(5)(6). P300 testing is an unbiased and non-invasive method, standardized for assessing cognitive processes (7)(8)(9)(10). We have reviewed the existing literature in this field to better understand the role of P300 testing in diagnostics of different diseases.…”

Section: Introductionmentioning

confidence: 99%

P300 as an auxiliary method in clinical practice: A review of literature

Titlić

Mihalj

Petrovic

et al. 2016

JHSCI

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Cognitive functions can be assessed and followed up over a period of time with cognitive evoked potentials (CEP) P300� In this context, brainstem auditory evoked potentials (BAEP) are most commonly used, but visual evoked potentials (VEP) are utilized as well� The research in this area has demonstrated that these techniques could be used as a supplemental method in diagnostics of numerous diseases such as Alzheimer's disease, mild cognitive impairment, vascular dementia, epilepsy, craniocerebral trauma, Parkinson's disease, multiple sclerosis, and other degenerative diseases� In addition, P300 can also be used as an auxiliary method in the diagnostics of mental disorders conditions such as schizophrenia, panic disorders, narcotic drug addiction, nicotinism, alcoholism, etc� The method assists in monitoring the course of diseases leading to encephalopathy, such as liver and kidney damage and grave anaemia� The advantages of P300 testing are easy application, non-invasiveness, and an unlimited number of potential applications� Moreover, the results obtained with this method are measurable and can be compared�

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Auditory target processing in methadone substituted opiate addicts: The effect of nicotine in controls

Cited by 14 publications

References 36 publications

Independent Component Analysis Applied to Pharmacological Magnetic Resonance Imaging (phMRI): New Insights Into the Functional Networks Underlying Panic Attacks as Induced by CCK-4

Independent Component Analysis Applied to Pharmacological Magnetic Resonance Imaging (phMRI): New Insights Into the Functional Networks Underlying Panic Attacks as Induced by CCK-4

Neuroelectrophysiological approaches in heroin addiction research: A review of literatures

P300 as an auxiliary method in clinical practice: A review of literature

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