Auditory processing in autism spectrum disorder: Mismatch negativity deficits

Vlaskamp, Chantal; Oranje, Bob; Madsen, Gitte; Jepsen, Jens Richardt Møllegaard; Durston, Sarah; Cantio, Cathriona; Glenthøj, Birte; Bilenberg, Niels

doi:10.1002/aur.1821

Cited by 53 publications

(45 citation statements)

References 51 publications

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“…Another study suggested that autistic school-age children do have auditory changes at the level measured by MMN, primarily preattentive responses ( 16 ). Vlaskamp et al ( 17 ) investigated MMN and P3a amplitudes in a large sample of children. The results indicated that MMN responses were reduced and P3a amplitudes were increased significantly in patients with ASDs.…”

Section: Central Auditory Processing Disorders and Autism Spectrum DImentioning

confidence: 99%

Central Auditory Processing Disorders in Individuals with Autism Spectrum Disorders

et al. 2018

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The etiology and the underlying pathogenetic mechanisms of autism spectrum disorders are still largely unknown. This article provides a comprehensive review of the studies that are relevant to autism spectrum disorders and central auditory processing disorders and also discusses the relationship between autism spectrum disorders and central auditory processing disorders in the light of recent studies on this subject, which may provide new pathways in a therapeutic perspective. Several studies confirm that most of the individuals with an autism spectrum disorder have some degree of sensory dysfunction related to disorders of processing auditory, visual, vestibular, and/or tactile stimuli. Among these studies, some have addressed central auditory processing disorders. There is an increasing amount of effort for studies regarding the link between autism spectrum disorders and central auditory processing disorders. Most of the studies investigating central auditory processing disorders in patients with autism spectrum disorders have used electrophysiological measurements such as mismatch negativity and P300 event-related potentials. In addition to these, several studies have reported deterioration in speech perception and expression in patients with autism spectrum disorders, which may also be related to central auditory processing disorders in this unique group of individuals.

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Section: Central Auditory Processing Disorders and Autism Spectrum DImentioning

confidence: 99%

Central Auditory Processing Disorders in Individuals with Autism Spectrum Disorders

et al. 2018

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“…Various electrophysiological and magnetoencephalographic studies have found evidence of altered latencies [31][32][33] and amplitudes [33,34] of cortical responses to auditory stimuli in ASD, yet at present, relatively few studies using such measures to investigate sensory processing in ASD have investigated heterogeneity. Admittedly, some studies do report differences based on presence or absence of intellectual disability [35], toleration of change [36], and verbal communication ability [37].…”

Section: Neurophysiologymentioning

confidence: 99%

“…Admittedly, some studies do report differences based on presence or absence of intellectual disability [35], toleration of change [36], and verbal communication ability [37]. Other studies exploring heterogeneity have reported associations between neurophysiological responses and various other variables in ASD [32,33,[38][39][40][41], including other measurements of sensory processing, such as questionnaires [34,[42][43][44][45]. However, no published neurophysiological studies have attempted to separate autistic individuals into subgroups based neural markers of sensory processing.…”

Section: Neurophysiologymentioning

confidence: 99%

Defining Clusters of Young Autistic and Typically-Developing Children Based on Loudness-Dependent Auditory Electrophysiological Responses

Dwyer

Wang

Meo-Monteil

et al. 2020

Preprint

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Background: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in Typical Development (TD) alongside Autism Spectrum Development (ASD). Methods: The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically-developing children based the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80 dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions. Results: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically-developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70 dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically-developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60 dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80 dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with both auditory distractibility and noise distress. This appears to provide evidence of coinciding behavioural and neural sensory atypicalities. Limitations : Replication may be needed to verify exploratory results. This analysis may ignore some variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Variability in sensory responses unrelated to loudness is ignored, leaving much room for additional research. Conclusions: Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviours, cognitive abilities, and autism diagnostic status.

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“…Various electrophysiological and magnetoencephalographic studies have found evidence of altered latencies [37][38][39] and amplitudes [39,40] of cortical responses to auditory stimuli in ASD, yet at present, relatively few studies using such measures to investigate sensory processing in ASD have investigated heterogeneity. Admittedly, some studies do report differences based on presence or absence of intellectual disability [41], toleration of change [42], and verbal communication ability [43].…”

Section: Neurophysiologymentioning

confidence: 99%

“…Admittedly, some studies do report differences based on presence or absence of intellectual disability [41], toleration of change [42], and verbal communication ability [43]. Another emerging group of studies exploring heterogeneity have reported associations between neurophysiological responses and various other variables in ASD [38,39,[44][45][46][47]. However, no published neurophysiological studies have attempted to separate autistic individuals into subgroups based neural markers of sensory processing.…”

Section: Neurophysiologymentioning

confidence: 99%

Defining Clusters of Young Autistic and Typically-Developing Children Based on Loudness-Dependent Auditory Electrophysiological Responses

Dwyer

Wang

Meo-Monteil

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have ordinarily used questionnaires and have rarely investigated sensory processing in Typical Development (TD) alongside Autism Spectrum Development (ASD). Methods:The present study used hierarchical clustering in a large sample to identify subgroups of young autistic and typically-developing children based the normalized global field power (GFP) of their event-related potentials (ERPs) to auditory stimuli of four different loudness intensities (50, 60, 70, 80 dB SPL): that is, based on an index of the relative strengths of their neural responses across these loudness conditions.Results: Four clusters of participants were defined. Normalized GFP responses to sounds of different intensities differed strongly across clusters. There was considerable overlap in cluster assignments of autistic and typically-developing participants, but autistic participants were more likely to display a pattern of relatively linear increases in response strength accompanied by a disproportionately strong response to 70 dB stimuli. Autistic participants displaying this pattern trended towards obtaining higher scores on assessments of cognitive abilities. There was also a trend for typically-developing participants to disproportionately fall into a cluster characterized by disproportionately/nonlinearly strong 60 dB responses. Greater auditory distractibility was reported among autistic participants in a cluster characterized by disproportionately strong responses to the loudest (80 dB) sounds, and furthermore, relatively strong responses to loud sounds were correlated with both auditory distractibility and noise distress. This appears to provide evidence of coinciding behavioural and neural sensory atypicalities. CLUSTERING LOUDNESS-DEPENDENT AUDITORY ERPS 3Limitations: Replication may be needed to verify exploratory results. This analysis may ignore some variability related to classical ERP latencies and topographies. The sensory questionnaire employed was not specifically designed for use in autism. Variability in sensory responses unrelated to loudness is ignored, leaving much room for additional research. Conclusions:Taken together, these data demonstrate the broader benefits of using electrophysiology to explore individual differences. They illuminate different neural response patterns and suggest relationships between sensory neural responses and sensory behaviours, cognitive abilities, and autism diagnostic status.

show abstract

Auditory processing in autism spectrum disorder: Mismatch negativity deficits

Cited by 53 publications

References 51 publications

Central Auditory Processing Disorders in Individuals with Autism Spectrum Disorders

Central Auditory Processing Disorders in Individuals with Autism Spectrum Disorders

Defining Clusters of Young Autistic and Typically-Developing Children Based on Loudness-Dependent Auditory Electrophysiological Responses

Defining Clusters of Young Autistic and Typically-Developing Children Based on Loudness-Dependent Auditory Electrophysiological Responses

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