Central Auditory Processing Disorders in Individuals with Autism Spectrum Disorders

Ocak, Emre; Eshraghi, Rebecca S.; Danesh, Ali A.; Mittal, Rahul; Eshraghi, Adrien A.

doi:10.4274/balkanmedj.2018.0853

Cited by 24 publications

(18 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we investigated how excitatory afferent input regulates neuronal FMRP through a systematic characterization of the time course of FMRP changes in primary cochlear neurons following afferent deprivation. In the auditory system, hearing impairment at young ages leads to neuronal loss and long‐term alterations of neuronal properties and connectivity (Clarkson, Antunes, & Rubio, 2016; Hagerman et al, 2017; Kotak et al, 2005; Ocak, Eshraghi, Danesh, Mittal, & Eshraghi, 2018; Takesian, Kotak, & Sanes, 2009). Unilateral cochlea removal provides a powerful approach for examining the effect of excitatory afferent deprivation or hearing loss on the central nervous system, particularly in the mammalian ventral cochlear nucleus (VCN) and its avian analogue, the nucleus magnocellularis (NM).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Wang

Sakano

et al. 2020

J of Comparative Neurology

View full text Add to dashboard Cite

Afferent activity dynamically regulates neuronal properties and connectivity in the central nervous system. The Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates cellular and synaptic properties in an activitydependent manner. Whether and how FMRP level and localization are regulated by afferent input remains sparsely examined and how such regulation is associated with neuronal response to changes in sensory input is unknown. We characterized changes in FMRP level and localization in the chicken nucleus magnocellularis (NM), a primary cochlear nucleus, following afferent deprivation by unilateral cochlea removal. We observed rapid (within 2 hr) aggregation of FMRP immunoreactivity into large granular structures in a subset of deafferented NM neurons. Neurons that exhibited persistent FMRP aggregation at 12-24 hr eventually lost cytoplasmic Nissl substance, indicating cell death. A week later, FMRP expression in surviving neurons regained its homeostasis, with a slightly reduced immunostaining intensity and enhanced heterogeneity. Correlation analyses under the homeostatic status (7-14 days) revealed that neurons expressing relatively more FMRP had a higher capability of maintaining cell body size and ribosomal activity, as well as a better ability to detach inactive presynaptic terminals. Additionally, the intensity of an inhibitory postsynaptic protein, gephyrin, was reduced following deafferentation and was positively correlated with FMRP intensity, implicating an involvement of FMRP in synaptic dynamics in response to reduced afferent inputs. Collectively, this study demonstrates that afferent input regulates FMRP expression and localization in ways associated with multiple types of neuronal responses and synaptic rearrangements.

show abstract

Section: Introductionmentioning

confidence: 99%

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Wang

Sakano

et al. 2020

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

“…Many individuals with autism (ASD) exhibit symptoms related to atypical selective auditory attention [American Psychiatric Association, 2013; Marco, Hinkley, Hill, & Nagarajan, 2011; Ocak, Eshraghi, Danesh, Mittal, & Eshraghi, 2018]. For instance, individuals with ASD often feel overwhelmed in loud, multisource settings [Alcántara, Weisblatt, Moore, & Bolton, 2004; Birch, 2003; Grandin, 1995], and overarousal may be related to overarching problems filtering targets from noise [Haigh, Heeger, Dinstein, Minshew, & Behrmann, 2015; Simmons et al, 2007; Vilidaite, Yu, & Baker, 2017].…”

Section: Introductionmentioning

confidence: 99%

Neural Evidence for Speech Processing Deficits During a Cocktail Party Scenario in Minimally and Low Verbal Adolescents and Young Adults with Autism

et al. 2020

View full text Add to dashboard Cite

As demonstrated by the Cocktail Party Effect, a person's attention is grabbed when they hear their name in a multispeaker setting. However, individuals with autism (ASD) are commonly challenged in multispeaker settings and often do not respond to salient speech, including one's own name (OON). It is unknown whether neural responses during this Cocktail Party scenario differ in those with ASD and whether such differences are associated with expressive language or auditory filtering abilities. We measured neural responses to hearing OON in quiet and multispeaker settings using electroencephalography in 20 minimally or low verbal ASD (ASD-MLV), 27 verbally fluent ASD (ASD-V), and 27 neurotypical (TD) participants, ages 13-22. First, we determined whether TD's neural responses to OON relative to other names could be quantified with early frontal mismatch responses (MMRs) and late, slow shift parietal and frontal responses (LPPs/ FNs). Second, we compared the strength of MMRs and LPPs/FNs across the three groups. Third, we tested whether participants with poorer auditory filtering abilities exhibited particularly weak neural responses to OON heard in a multispeaker setting. Our primary finding was that TDs and ASD-Vs, but not ASD-MLVs, had significant MMRs to OON in a multispeaker setting, and strength of LPPs positively correlated with auditory filtering abilities in those with ASD. These findings reveal electrophysiological correlates of auditory filtering disruption within a clinical population that has severe language and communication impairments and offer a novel neuroimaging approach to studying the Cocktail Party effect in neurotypical and clinical populations.

show abstract

“…Moreover, unlike the puzzle in Shic's study, which is a silent game, our activity was playing a xylophone therefore producing musical tone. Considering that presenting a congruent sound induces faster orientation towards a target stimulus during a visual exploration task [55] and that children with ASD demonstrate atypical auditory processing with preserved or heightened abilities in musical processing [56,57], the auditory component might have biased attentional focus in the two paradigms in different ways. Third, Shic et al [16] proposed that children attend to elements that are within reach of their ability to comprehend, according to McCall and McGhee's [58] moderate discrepancy hypothesis, which could result in reduced attention to the shared activity especially in children with higher symptom severity.…”

Section: Discussionmentioning

confidence: 99%

The impact of social complexity on the visual exploration of others' actions in preschoolers with autism spectrum disorder

et al. 2021

View full text Add to dashboard Cite

Background Typical development of socio-communicative skills relies on keen observation of others. It thus follows that decreased social attention negatively impacts the subsequent development of socio-communicative abilities in children with autism spectrum disorders (ASD). In addition, studies indicate that social attention is modulated by context and that greater social difficulties are observed in more socially demanding situations. Our study aims to investigate the effect of social complexity on visual exploration of others’ actions in preschoolers. Methods To investigate the impact of social complexity, we used an eye-tracking paradigm with 26 typically developing preschoolers (TD, age = 3.60 ± 1.55) and 37 preschoolers with ASD (age = 3.55 ± 1.21). Participants were shown videos of two children engaging in socially simple play (parallel) versus socially complex play (interactive). We subsequently quantified the time spent and fixation duration on faces, objects, bodies, as well as the background and the number of spontaneous gaze shifts between socially relevant areas of interest. Results In the ASD group, we observed decreased time spent on faces. Social complexity (interactive play) elicited changes in visual exploration patterns in both groups. From the parallel to the interactive condition, we observed a shift towards socially relevant parts of the scene, a decrease in fixation duration, as well as an increase in spontaneous gaze shifts between faces and objects though there were fewer in the ASD group. Limitations Our results need to be interpreted cautiously due to relatively small sample sizes and may be relevant to male preschoolers, given our male-only sample and reported phenotypic differences between males and females. Conclusion Our results suggest that similar to TD children, though to a lesser extent, visual exploration patterns in ASD are modulated by context. Children with ASD that were less sensitive to context modulation showed decreased socio-communicative skills or higher levels of symptoms. Our findings support using naturalistic designs to capture socio-communicative deficits in ASD.

show abstract

Central Auditory Processing Disorders in Individuals with Autism Spectrum Disorders

Cited by 24 publications

References 57 publications

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation

Neural Evidence for Speech Processing Deficits During a Cocktail Party Scenario in Minimally and Low Verbal Adolescents and Young Adults with Autism

The impact of social complexity on the visual exploration of others' actions in preschoolers with autism spectrum disorder

Contact Info

Product

Resources

About