Auditory Outcome After Cochlear Implantation in Patients With Congenital Nonsyndromic Hearing Loss

Popov, T.; Stancheva, I; Kachakova, Darina; Rangachev, J.; Konov, D.; Varbanova, S.; Mitev, Vanio; Kaneva, Radka; Попова, Д.

doi:10.1097/mao.0000000000000348

Cited by 9 publications

(4 citation statements)

References 29 publications

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“… 39 The tool was also used to compare patients with different age groups 40 or patients with the same age but different groups with various etiologic factors for hearing loss. 41 Although different age groups and different etiologic factors on hearing loss demonstrate different improvement charts, in general following implantation and rehabilitation, auditory perception improves over time and this improvement occurs steadily over 6 month or 1-year intervals. 38 Also the studies demonstrated that the earlier the implantation the better the auditory responses.…”

Section: Discussionmentioning

confidence: 99%

Does size of the cochlear nerve affect postoperative auditory performance in pediatric cochlear implant patients with normal cochlear nerves?

Gözen

Yener

Kara

et al. 2022

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Does size of the cochlear nerve affect postoperative auditory performance in pediatric cochlear implant patients with normal cochlear nerves?

Gözen

Yener

Kara

et al. 2022

Brazilian Journal of Otorhinolaryngology

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“…The first locus for autosomal recessive NSHL was mapped to 13q12 (Guilford et al, 1994), which subsequently led to the identification of mutations in GJB2 (MIM 121011) (Kelsell et al, 1997). This gene is considered to be responsible for up to 50% of autosomal recessive NSHL in childhood in many parts of the world (Guilford et al, 1994; Popov et al, 2014). Prior to 2010, despite intense efforts by leading laboratories over nearly two decades, only 60 deafness genes had been discovered.…”

Section: Gene Discovery In Nshl: the Impact Of Wesmentioning

confidence: 99%

Whole-exome sequencing and its impact in hereditary hearing loss

et al. 2015

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Summary Next-generation sequencing (NGS) technologies have played a central role in the genetic revolution. These technologies, especially whole-exome sequencing, have become the primary tool of geneticists to identify the causative DNA variants in Mendelian disorders, including hereditary deafness. Current research estimates that 1% of all human genes have a function in hearing. To date, mutations in over 80 genes have been reported to cause nonsyndromic hearing loss (NSHL). Strikingly, more than a quarter of all known genes related to NSHL were discovered in the past 5 years via NGS technologies. In this article, we review recent developments in the usage of NGS for hereditary deafness, with an emphasis on whole-exome sequencing.

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“…Thus, it is necessary to periodically monitor children with CIs not only to make adjustments related to the programming of the electronic device, but also to check the development and rhythm of the development of auditory and linguistic abilities. To evaluate the ability of auditory speech perception in silence, there are different procedures, including the Glendonald Auditory Screening Procedure (GASP) (18,19) , which has been shown to be an effective evaluation instrument for assessing the auditory performance of children with hearing loss (3,(20)(21)(22) .…”

Section: Introductionmentioning

confidence: 99%

Glendonald Auditory Screening Procedure (GASP): marcadores clínicos de desenvolvimento das habilidades de reconhecimento e compreensão auditiva em crianças usuárias de implante coclear

Silva

Moret

Silva

et al. 2019

CoDAS

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RESUMO Objetivo Verificar a influência da idade de implantação no desenvolvimento das habilidades de reconhecimento auditivo em conjunto fechado e compreensão auditiva em crianças usuárias de implante coclear unilateral, comparando grupos distintos e determinar os marcadores clínicos de desenvolvimento destas habilidades. Método Participaram do estudo 180 crianças operadas e ativadas até os 36 meses de idade e que utilizaram o IC durante, no mínimo, 60 meses. Foram analisadas as habilidades de reconhecimento auditivo em conjunto fechado e compreensão auditiva por meio das Provas 5 e 6 do GASP. Para investigar a influência da idade na implantação, as crianças foram divididas em três grupos: implantadas antes dos 18 meses (G1), entre 19 e 24 meses (G2) e entre 25 e 36 meses de idade (G3). Resultados Não houve diferença estatisticamente significante quando comparados os três grupos. As crianças desenvolveram progressivamente as habilidades auditivas, apresentando a habilidade de reconhecimento auditivo em conjunto fechado por volta dos 41±4 meses de uso do IC e a de compreensão auditiva por volta dos 53±4 meses. Conclusão Não houve correlação entre o desempenho auditivo e a idade de implantação para as crianças implantadas antes dos 36 meses de idade. Para as habilidades de reconhecimento e compreensão auditivas, o marcador clínico foi aos 41±4 e aos 53±4 meses de idade auditiva, respectivamente. Para tanto, espera-se que, por volta dos 60 meses de uso do IC, as crianças implantadas durante o período sensível possam compreender a fala sem o auxílio da leitura orofacial, alcançando as habilidades auditivas mais complexas.

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Auditory Outcome After Cochlear Implantation in Patients With Congenital Nonsyndromic Hearing Loss

Abstract: The results from our study suggest that children with GJB2-related deafness show better auditory performance after cochlear implantation than age-matched children with GJB2-nonrelated sensorineural hearing loss.

Cited by 9 publications

References 29 publications

Does size of the cochlear nerve affect postoperative auditory performance in pediatric cochlear implant patients with normal cochlear nerves?

Does size of the cochlear nerve affect postoperative auditory performance in pediatric cochlear implant patients with normal cochlear nerves?

Whole-exome sequencing and its impact in hereditary hearing loss

Glendonald Auditory Screening Procedure (GASP): marcadores clínicos de desenvolvimento das habilidades de reconhecimento e compreensão auditiva em crianças usuárias de implante coclear

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