Auditory findings associated with Zika virus infection: an integrative review

Barbosa, Maria Helena de Magalhães; Magalhães-Barbosa, Maria Clara de; Robaina, Jaqueline Rodrigues; Prata‐Barbosa, Arnaldo; Lima, Maria Luiza Cunha; Cunha, Antonio José Ledo Alves da

doi:10.1016/j.bjorl.2019.05.002

Cited by 31 publications

(32 citation statements)

References 57 publications

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“…The prevalence of ocular disorder was reported in five SRs ranging from 0.9%% (from one study with 395 livebirth pregnancies) to 58.6% (17 ocular findings with microcephaly associated in 29 infants) 15 18 21 24 25 30 32. Abnormal amniotic fluid was described only by Krauer et al 15 Auditory disorder was described by Krauer et al 15 (prevalence of 13%—3 cases in 24 mother–infant pairs) and Soriano-Arandes et al 26 (prevalence of 7%—5 cases in 70 children with laboratory diagnosis of ZIKV infection) and Barbosa et al 34 (variations in the frequency of altered otoacoustic emissions testing (OAE) and automated auditory brainstem (a-ABR) response testing across the studies in 515 children: altered OAE varied from 0% to 75%, while altered a-ABR varied from 0% to 29.2%). The prevalence of cardiovascular damage was reported by Coelho et al 18 (prevalence of 1%—3 cases in 301 livebirth pregnancies), Soriano-Arandes et al 26 (prevalence of 13.6%—14 cases in103 ZIKV cases) and Minhas et al 35 (prevalence of 67% of heart failure in a cohort with nine adults positive for ZIKV and no previous cardiac history).…”

Section: Resultsmentioning

confidence: 98%

“…After screening titles and abstracts, we selected 85 for full-text screening. Of these, 21 met our inclusion criteria 15–35. The main reasons for exclusion at the full-text stage were articles not being SRs (but rather overviews or literature reviews) and studies only reported symptoms but not outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 21 included SRs, the most commonly reported outcome was microcephaly, reported in 14 SRs,15–26 30 32 12 SRs reported on GBS,15 16 19 20 22 23 25 27 29–31 33 11 SRs reported on malformations or congenital abnormalities,18–20 22 26 30–34 9 reported on brain,15 17 21 24–26 28 30 32 7 SRs reported on ocular disorders15 18 21 24 25 30 32 and 6 SRs on termination of pregnancy, fetal death and perinatal death 15 18–20 30 33. Three SRs or fewer reported on auditory disorder,15 26 34 cardiovascular damage,18 26 35 neurological complications,16 25 33 intrauterine growth restrictions,15 25 abnormal amniotic fluid,15 epilepsy21 and death due Zika infection 16…”

Section: Resultsmentioning

confidence: 99%

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Health outcomes associated with Zika virus infection in humans: a systematic review of systematic reviews

et al. 2019

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ObjectiveWith the emergence of Zika virus (ZIKV) disease in Central and South America in the mid-2010s and recognition of the teratogenic effects of congenital exposure to ZIKV, there has been a substantial increase in new research published on ZIKV. Our objective is to synthesise the literature on health outcomes associated with ZIKV infection in humans.MethodsWe conducted a systematic review (SR) of SRs following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched MEDLINE, Embase, Cochrane and LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde) databases from inception to 22 July 2019, and included SRs that reported ZIKV-associated health outcomes. Three independent reviewers selected eligible studies, extracted data and assessed the quality of included SRs using the AMSTAR 2 (A MeaSurement Tool to Assess Systematic Reviews 2) tool. Conflicts were resolved by consensus or consultation with a third reviewer.ResultsThe search yielded 1382 unique articles, of which 21 SRs met our inclusion criteria. The 21 SRs ranged from descriptive to quantitative data synthesis, including four meta-analyses. The most commonly reported ZIKV-associated manifestations and health outcomes were microcephaly, congenital abnormalities, brain abnormalities, neonatal death and Guillain-Barré syndrome. The included reviews were highly heterogeneous. The overall quality of the SRs was critically low with all studies having more than one critical weakness.ConclusionThe evolving nature of the literature on ZIKV-associated health outcomes, together with the critically low quality of existing SRs, demonstrates the need for high-quality SRs to guide patient care and inform policy decision making.PROSPERO registration numberCRD42018091087.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Health outcomes associated with Zika virus infection in humans: a systematic review of systematic reviews

et al. 2019

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“…Seven (38.9%) presented a hearing evaluation suggestive of middle ear alterations in at least one of the ears at the time of the audiometric/imitanciometric test. All of those children (7) presented congested upper airways at the time of the exam (i.e., congested mucosa, rhinorrhea, report of recent upper airway infection or allergic exacerbation). One of the children (n.2) had already presented this type of condition since the neurodiagnostic ABR test, at 23 months of life, in which delayed wave absolute latencies were identified.…”

Section: Resultsmentioning

confidence: 99%

“…[3][4][5] However, few studies to date have assessed the hearing function of infected children without microcephaly. 6,7 On the other hand, ocular findings in non-microcephalic children have been reported. 8 The hearing screening of children with risk indicators for hearing loss must be conducted by the otoacoustic emission (OAE) and the auditory brainstem response (ABR) tests.…”

Section: Introductionmentioning

confidence: 99%

Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Barbosa

Garcia

Magalhães‐Barbosa

et al. 2019

Int Arch Otorhinolaryngol

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Introduction The association between prenatal Zika virus infection and hearing alterations in offspring has been the object of some studies, although few have assessed children without microcephaly. However, a current trend to include prenatal Zika virus exposure in the group of risk indicators for hearing loss is noted. Objective To present a series of 27 children prenatally exposed to the Zika virus submitted to multiple hearing assessments over time. Methods A cohort of children born to symptomatic mothers with laboratorial Zika virus infection confirmation during pregnancy was submitted to an otoacoustic emission test, auditory brainstem response test (automated, neurodiagnostic and frequency-specific), audiometry, and imitanciometry over a period of 36 months since birth. The hearing assessment was performed independently of the presence of microcephaly or other apparent signs of congenital Zika syndrome. Results The hearing tests presented predominantly normal results. Some children had signs of middle ear pathology. The only microcephalic child had normal electrophysiological tests, as well as preserved audiometric thresholds, but presented altered motor responses to sound. Conclusion Prenatal exposure to Zika virus does not always determine hearing impairment. This risk seems to be more associated to the severity of the central nervous system damage. Hearing screening and follow-ups of the affected children are important, as well as further research in this area.

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Zika virus can directly infect and damage the auditory and vestibular components of the embryonic chicken inner ear

Thawani

Sammudin

Reygaerts

et al. 2020

Developmental Dynamics

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Background: Sensorineural hearing loss is an understudied consequence of congenital Zika syndrome, and balance disorders are essentially unreported to date. Also lacking is information about the susceptibility and the pathogenesis of the developing inner ear following Zika virus (ZIKV) exposure. To address this, ZIKV was delivered directly into the otic cup/otocyst of chicken embryos and infection of inner ear tissues was evaluated using immunohistochemistry. Results: After injections on embryonic days 2 to 5, ZIKV infection was observed in 90% of the samples harvested 2 to 8 days later; however, the degree of infection was highly variable across individuals. ZIKV was detected in all regions of the inner ear, associated ganglia, and in the surrounding periotic mesenchyme. Detection of virus peaked earlier in the ganglion and vestibular compartments, and later in the cochlea. ZIKV infection increased cell death robustly in the auditory ganglion, and modestly in the auditory sensory organ. Macrophage accumulation was found to overlap with dense viral infection in some tissues. Additionally, dysmorphogenesis of the semicircular canals and ganglion was observed for a subset of injection conditions.Conclusions: This article presents evidence of direct ZIKV infection of developing inner ear epithelium and shows previously unknown inner ear dysmorphogenesis phenotypes.

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Auditory findings associated with Zika virus infection: an integrative review

Cited by 31 publications

References 57 publications

Health outcomes associated with Zika virus infection in humans: a systematic review of systematic reviews

Health outcomes associated with Zika virus infection in humans: a systematic review of systematic reviews

Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Zika virus can directly infect and damage the auditory and vestibular components of the embryonic chicken inner ear

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