Auditory event-related potentials (P300) in partial and generalized epileptic patients

Abstract

We evaluated the P300 components of event-related potentials (ERP) in 64 cryptogenic partial epilepsy (CPE) patients, and 52 idiopathic generalized epilepsy (IGE) patients as well as in their age-matched control groups. The P200, N200 and P300 latencies recorded from Cz were significantly longer in CPE patients compared with those of their control group (P = 0.0371, P = 0.0092 and P = 0.0405, respectively). The P200 and N200 latencies recorded from Fz were significantly longer than in their control group (P = 0.0448 and P = 0.0107) while the prolongation in the P300 latencies was not found to be statistically significant (P = 0.0733). All latencies were longer in IGE patients, and the amplitudes of the N200/P300 components of ERP were lower in both epileptic groups compared with their control groups, but these differences were not significant. The prolongation of the P300 latencies was not correlated with the type or serum level of antiepileptic drug or seizure control. Our findings suggest that the prolongation of the P300 latency of ERP is related to the type of epilepsy.

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

“…Nevertheless, Soysal et al 28 and Celebisoy et al 10 found no such correlation. Also, Ozmenek et al 24 and Soyal et al 28 found that chronic epilepsy patients had more prolonged P300 latencies than did normal individuals and there were significant differences on the basis of seizure type and anticonvulsant concentration. In the latest study, P300 latencies were longer in idiopathic primary generalized epilepsy than in secondary generalized epilepsy.…”

Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

“…Event-related potential (ERP) is an important method to evaluate the cognitive status of epilepsy patients (e.g., Sunaga et al, 1994;Soysal et al, 1999;Rodin et al, 1999;Tendon and Duban, 2000;Trinka et al, 2000;Sun et al, 2007). Differences in timing and scalp topography of particular ERP components allow inferences about the timing and spatial characteristics of brain activity involved in cognitive processing (Rugg and Coles, 1995).…”

Antiepileptic Drugs and the Significance of Event-Related Potentials

“…The earliest identified member of this family, auditory ERP-P300, is used as an objective criterion for evaluating cognitive functions. Clinical studies showed delayed and smaller P300 in epileptics compared with controls; irregular waves can also be observed in those patients (Soysal et al, 1999;Rodin et al, 1999;Trinka et al, 2001). In the traditional auditory oddball paradigm, P300 is elicited by an event that is both infrequent and task relevant.…”