Auditory event related potentials in patients with epilepsy on sodium valproate monotherapy

Panagopoulos, Gregory; Thomaides, T.; Tagaris, G.; Karageorgiou, Climentini

doi:10.1111/j.1600-0404.1997.tb00240.x

Cited by 16 publications

(6 citation statements)

References 11 publications

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“…The time span between seizure onset and ERP recording needs to be further investigated. Secondly, the effect of antiepileptic drugs (AEDs) may not be neglected [33][34][35]. There was not significant difference in MMN/MMP between the group with monotherapy and that with polytherapy, which was consistent with the previous finding [36].…”

Section: Mmn/mmp Changes In Tle Patientssupporting

confidence: 87%

Mismatch negativity is abnormal but not lateralizing in temporal lobe epilepsy

Zhao

Mao

et al. 2017

Epilepsy & Behavior

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We investigated the changes of mismatch negativity (MMN) in patients with temporal lobe epilepsy (TLE) and explored the possible role of MMN in lateralizing their seizure focus. Thirty patients with TLE and thirty healthy controls were included. MMN was elicited in each subject. Patients with TLE were divided into three subgroups: unilateral left TLE; unilateral right TLE, and bilateral TLE. MMN amplitudes and latencies were compared between the patients with TLE and the control group, and also among the three subgroups of TLE, using repeated measures analyses of variance (ANOVA). To assess the lateralizing value of MMN, MMN latencies and amplitudes at the mastoid sites between the ipsilateral and contralateral sides of epileptic focus in patients with unilateral TLE were compared using t-test. Compared with controls, each subgroup of patients with TLE had longer latencies of MMN at both fronto-central and mastoid sites, but the amplitudes of MMN were not significantly different. The amplitudes and latencies of MMN were not significantly different between the ipsilateral and contralateral sides of seizure focus at mastoid sites. The present findings of prolonged latencies of MMN are suggestive of cognitive impairment in TLE. Both the mastoid sites and the fronto-central sites are involved, which likely reflect widespread cortical abnormalities in TLE. However, the changes of MMN during the interictal phase are not useful for lateralizing the seizure focus in patients with TLE.

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Section: Mmn/mmp Changes In Tle Patientssupporting

confidence: 87%

Mismatch negativity is abnormal but not lateralizing in temporal lobe epilepsy

Zhao

Mao

et al. 2017

Epilepsy & Behavior

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“…Similar observations have been reported for valproic acid (VPA). Pana-gopoulos et al found a significantly prolonged P300 latency in patients taking VPA, while no cognitive impairment was observed in children taking VPA 8,20 . Naganuma et al examined auditory ERP in patients with benign childhood epilepsy with centrotemporal spike and found that P300 latency was significantly prolonged in patients receiving CBZ, but Chen et al failed to detect cognitive impairment in children on CBZ 8,21 .…”

Section: Discussionmentioning

confidence: 95%

Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy

Jurić

Marković

et al. 2021

ACC

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Epilepsy is one of the most prevalent chronic neurological diseases, affecting about 70 million people worldwide. Patients with epilepsy often encounter cognitive dysfunction, which is influenced by different factors including age at the onset of epilepsy, etiology of epilepsy, type of seizures, seizure frequency and duration, psychiatric comorbidity, and antiepileptic drug (AED) therapy. Event-related potentials are useful, noninvasive, objective clinical and research instrument for evaluation of cognitive functions in patients. The aim of this study was to investigate and determine the effect of AED monotherapy and polytherapy on cognitive changes in patients with epilepsy, detected with P300 event-related potentials and compared with age-and gender-matched healthy individuals. The study was conducted in 82 patients with generalized and focal epilepsy and 82 healthy individuals aged 18-65 years. Cognitive evoked P300 potentials were recorded in all study subjects using auditory 'oddball' paradigm. The results showed the patients taking AED polytherapy to have a significantly longer P300 latency and significantly lower N200-P300 amplitude. These results indicate that AED polytherapy might worsen cognitive impairment in patients with epilepsy.

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“…The influence of anti-epileptic medication on P300 remains controversial. [37][38][39][40][41][42] The small number of participants in this study, combined with the use of multiple drugs by many of our patients, makes it difficult to discuss the possible influence of medication on our results. A direct comparison was impossible since the doses of different substances cannot be meaningfully compared.…”

Section: Discussionmentioning

confidence: 99%