Auditory event-related potential abnormalities in bipolar disorder and schizophrenia

O’Donnell, Brian F.; Vohs, Jenifer L.; Hetrick, William P.; Carroll, Christine A.; Shekhar, Anantha

doi:10.1016/j.ijpsycho.2004.02.001

Cited by 171 publications

(143 citation statements)

References 34 publications

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“…Amplitude reductions and latency delays of the N100 wave have been described in chronic schizophrenia (Frangou et al, 1997;Karoumi et al, 2000;O'Donnell et al, 2004;Wood et al, 2006), but have not been evident in the non-psychotic relatives of patients (Frangou et al, 1997;Karoumi et al, 2000). To our knowledge, this is the first examination of N100 performance in the at-risk mental state.…”

Section: Discussionmentioning

confidence: 82%

“…To our knowledge, this is the first examination of N100 performance in the at-risk mental state. The existing evidence, although more limited than that for P300, indicates that the N100 deficits are not markers of risk but rather a correlate of chronic psychotic symptoms (Brown et al, 2002;Javitt et al, 2000;Kogoj et al, 2005;O'Donnell et al, 2004;Roth et al, 1980;Shelley et al, 1999;Sumich et al, 2007).…”

Section: Discussionmentioning

confidence: 97%

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Abnormal P300 in people with high risk of developing psychosis

et al. 2008

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Background: Individuals with an "At Risk Mental State" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.Method: 35 cases meeting PACE criteria for the At Risk Mental State (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 ±6.4 microvolt] compared to controls [12.7 ±5.8 microvolt] (p<0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis. Please find attached a fully revised manuscript titled "Abnormal P300 in people with high risk of developing psychosis". We also enclose a letter with the comments from the reviewers and our detailed answers on how we have done all the changes requested. (t-test; p=0.93). Those making a transition to psychosis were marginally more educated but this was only at trend level with a 3 year average difference in the age at which they completed their studies (t-test; p=0.07).Similarly, logistic regression analyses showed that compared to those who remained at risk, the seven cases who made a transition to psychosis had no significant differences in P300 amplitude/latency or N100 amplitude/latency (p values ranging from 0.30 to 0.63 for all four analyses). We have reported these comparisons very concisely and cautiously because referee #2 said that these analyses with only 7 individual making a transition were preliminary and power is limited. Please see results section paragraph 2. RESPONSE TO REVIEWER #2:Thank you for your suggestions, which have improved the paper. Below are your comments in blue-italics and how we have amended the manuscript accordingly in black with cross-references to the revised manuscript.This paper addresses an important and timely topic, namely, whether auditory P300 is reduced in subjects with at risk mental states and whether the P300 predicts subsequent conversion to psychosis. The study finds a significant deficit in P300 in ARMS subjects, relative to controls, replicating a previously a previously published report. The study had the potential to incrementally * 2. Response to Reviews 2 contribute to the literature by examining the utility of baseline P300 deficits as a predictor of subsequent conversion to psychosis; however, the negative finding coupled with the lack of power for this analysis (only 7 converters) make this aspect of the study inconclusive. More detailed comments are provided below:We have added a paragraph in the discussion to acknowledge the limitation of our small group of converters and how we have low statistical power to compa...

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 97%

Abnormal P300 in people with high risk of developing psychosis

et al. 2008

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“…Patients with bipolar disorder seem to show more consistent P300 deviations in both latency and amplitude than those with unipolar disorder (Vandoolaeghe et al, 1998). Whereas the magnitude of P300 abnormalities in bipolar disorder may be equal to those seen in schizophrenia (O'Donnell et al, 2004), differences in scalp topography may indicate differences in the affected neural generators (Salisbury et al, 1999).…”

Section: Mood Disordersmentioning

confidence: 90%

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan

Barry

Connolly

et al. 2009

Clinical Neurophysiology

996

845

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“…Cognitive deficits in BD may indicate that EEG recorded under cognitive task conditions would be better suited to identify electrophysiological correlates of cognitive dysfunctions. Event-related potential studies of P300 peak amplitudes produced inconsistent results in BD; Some studies reported reduced P300 amplitudes (Muir et al 1991;El-Badri et al 2001;Salisbury et al 1998Salisbury et al , 1999O'Donnell et al 2003O'Donnell et al , 2004bFridberg et al 2009), while some others reported no difference between healthy controls and patients with BD (Souza et al 1995;Strik et al 1998;Hall et al 2007;Kaya et al 2007;Schulze et al 2007Schulze et al , 2008.…”

Section: Introductionmentioning

confidence: 99%

Decrease of theta response in euthymic bipolar patients during an oddball paradigm

et al. 2012

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Theta oscillations are related to cognitive functions and reflect functional integration of frontal and medial temporal structures into coherent neurocognitive networks. This study assessed event-related theta oscillations in medication-free, euthymic patients with bipolar disorder upon auditory oddball paradigm. Twenty-two DSM-IV euthymic bipolar I (n = 19) and II (n = 3) patients and twenty-two healthy subjects were included. Patients were euthymic for at least 6 months, and psychotropic-free for at least 2 weeks. EEG was recorded at 30 electrode sites. Auditory oddball paradigm and sensory stimuli were used. Event-related Oscillations were analyzed using adaptive filtering in two different theta frequency bands (4-6 Hz, 6-8 Hz). In healthy subjects, slow theta (4-6 Hz) responses were significantly higher than those of euthymic patients upon target, non-target and sensory stimuli (p \ 0.05). Fast theta (6-8 Hz) responses of healthy subjects were significantly higher than those of euthymic patients upon target-only stimuli (p \ 0.05). Reduced theta oscillations during auditory processing provide strong quantitative evidence of activation deficits in related networks in bipolar disorder. Fast theta responses are related to cognitive functions, whereas slow theta responses are related to sensory processes more than cognitive processes.

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Auditory event-related potential abnormalities in bipolar disorder and schizophrenia

Cited by 171 publications

References 34 publications

Abnormal P300 in people with high risk of developing psychosis

Abnormal P300 in people with high risk of developing psychosis

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Decrease of theta response in euthymic bipolar patients during an oddball paradigm

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