Auditory event-related brain potentials in fibromyalgia syndrome

Alanoğlu, Ece; Ulaş, Ümit Hıdır; Özdağ, Fatih; Odabaşı, Zeki; Çakçı, Aytül; Vural, Okay

doi:10.1007/s00296-004-0443-3

Cited by 41 publications

(51 citation statements)

References 22 publications

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“…A consistent finding in FM patients is reduced amplitude of the p300 component compared to controls [27][28][29]. In contrast, the findings are less consistent with regard to p300 latency.…”

Section: Neuroimaging Studies In Cfs and Fmcontrasting

confidence: 57%

“…In contrast, the findings are less consistent with regard to p300 latency. Two studies found no difference in the latency of p300 [28,29], and one found increased latency [27]. Latency is often interpreted as indicating the speed of stimulus classification, and amplitude as an index of the brain activity associated with the task.…”

Section: Neuroimaging Studies In Cfs and Fmmentioning

confidence: 98%

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Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: New trends and future directions

Glass

2006

Curr Rheumatol Rep

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Fibromyalgia (FM) and chronic fatigue syndrome (CFS) patients often have memory and cognitive complaints. Objective cognitive testing demonstrates long-term and working memory impairments. In addition, CFS patients have slow information-processing, and FM patients have impaired control of attention, perhaps due to chronic pain. Neuroimaging studies demonstrate cerebral abnormalities and a pattern of increased neural recruitment during cognitive tasks. Future work should focus on the specific neurocognitive systems involved in cognitive dysfunction in each syndrome.

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Section: Neuroimaging Studies In Cfs and Fmcontrasting

confidence: 57%

Section: Neuroimaging Studies In Cfs and Fmmentioning

confidence: 98%

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: New trends and future directions

Glass

2006

Curr Rheumatol Rep

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“…Some previous studies indicated that, in patients with FM, cognitive performance is inversely related to self-reported pain (21,22), while other authors demonstrated an absence of this relationship in FM patients (15,23) and in female CFS patients (24). However, to the best of our knowledge the association between cognitive performance and experimental pain measurements and established measures of CS has never been examined in CFS patients.…”

Section: Participants and Assessmentsmentioning

confidence: 57%

Associations between cognitive performance and pain in chronic fatigue syndrome: comorbidity with fibromyalgia does matter

et al. 2015

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Background: In addition to the frequently reported pain complaints, performance-based cognitive capabilities in patients with chronic fatigue syndrome (CFS) with and without comorbid fibromyalgia (FM) are significantly worse than those of healthy controls. In various chronic pain populations, cognitive impairments are known to be related to pain severity. However, to the best of our knowledge, the association between cognitive performance and experimental pain measurements has never been examined in CFS patients.Objectives: This study aimed to examine the association between cognitive performance and self-reported as well as experimental pain measurements in CFS patients with and without FM.Study Design: Observational study.Setting: The present study took place at the Vrije Universiteit Brussel and the University of Antwerp.Methods: Forty-eight (18 CFS-only and 30 CFS+FM) patients and 30 healthy controls were studied. Participants first completed 3 performance-based cognitive tests designed to assess selective and sustained attention, cognitive inhibition, and working memory capacity. Seven days later, experimental pain measurements (pressure pain thresholds [PPT], temporal summation [TS], and conditioned pain modulation [CPM]) took place and participants were asked to fill out 3 questionnaires to assess self-reported pain, fatigue, and depressive symptoms.Results: In the CFS+FM group, the capacity of pain inhibition was significantly associated with cognitive inhibition. Self-reported pain was significantly associated with simple reaction time in CFS-only patients. The CFS+FM but not the CFS-only group showed a significantly lower PPT and enhanced TS compared with controls. Limitations:The cross-sectional nature of this study does not allow for inferences of causation. Conclusions:The results underline disease heterogeneity in CFS by indicating that a measure of endogenous pain inhibition might be a significant predictor of cognitive functioning in CFS patients with FM, while self-reported pain appears more appropriate to predict cognitive functioning in CFS patients without FM.

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“…In FMS perceptual amplification of pain, and neurosensitization are observed, both of which might be related to disinhibitory mechanisms (Howe and Sterman 1972). Ozgocmen et al (2002Ozgocmen et al ( , 2003, and Alanoglu et al (2005) demonstrated reduced P300 amplitudes in patients with FMS. As P300 has been proposed to reflect the activation of inhibitory processes, these findings are important.…”

Section: Introductionmentioning

confidence: 94%

Neurofeedback Intervention in Fibromyalgia Syndrome; a Randomized, Controlled, Rater Blind Clinical Trial

Kayıran

Dursun

et al. 2010

Appl Psychophysiol Biofeedback

104

101

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We designed a randomized, rater blind study to assess the efficacy of EEG Biofeedback (Neurofeedback-NFB) in patients with fibromyalgia syndrome (FMS). Eighteen patients received twenty sessions of NFB-sensory motor rhythm (SMR) treatment (NFB group) during 4 weeks, and eighteen patients were given 10 mg per day escitalopram treatment (control group) for 8 weeks. Visual Analog Scales for pain and fatigue, Hamilton and Beck Depression and Anxiety Inventory Scales, Fibromyalgia Impact Questionnaire and Short Form 36 were used as outcome measures which were applied at baseline and 2nd, 4th, 8th, 16th, 24th weeks. Mean amplitudes of EEG rhythms (delta, theta, alpha, SMR, beta1 and beta2) and theta/SMR ratio were also measured in NFB group. All post-treatment measurements showed significant improvements in both of the groups (for all parameters p < 0.05). NFB group displayed greater benefits than controls (for all parameters p < 0.05). Therapeutic efficacy of NFB was found to begin at 2nd week and reached to a maximum effect at 4th week. On the other hand, the improvements in SSRI treatment were also detected to begin at 2nd week but reached to a maximum effect at 8th week. No statistically significant changes were noted regarding mean amplitudes of EEG rhythms (p > 0.05 for all). However, theta/SMR ratio showed a significant decrease at 4th week compared to baseline in the NFB group (p < 0.05). These data support the efficacy of NFB as a treatment for pain, psychological symptoms and impaired quality of life associated with fibromyalgia.

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Auditory event-related brain potentials in fibromyalgia syndrome

Abstract: The results of our study reveal that FMS affects quality of life and dysfunction in cognitive abilities can be determined by brain event-related potentials.

Cited by 41 publications

References 22 publications

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: New trends and future directions

Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: New trends and future directions

Associations between cognitive performance and pain in chronic fatigue syndrome: comorbidity with fibromyalgia does matter

Neurofeedback Intervention in Fibromyalgia Syndrome; a Randomized, Controlled, Rater Blind Clinical Trial

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