Auditory cortex stimulation for tinnitus

Ridder, Dirk De; Mulder, Gert De; Verstraeten, Edwin; Seidman, Michael D.; Elisevich, Kost; Sunaert, Stefan; Kovacs, Silvia; Kelen, Karolien Van der; Heyning, Paul Van de; Møller, Aage R.

doi:10.1007/978-3-211-33081-4_52

Cited by 85 publications

(47 citation statements)

References 113 publications

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“…Also wire electrodes have been inserted in the primary auditory cortex, with comparable results (De Ridder et al, 2007a; Seidman et al, 2008). …”

Section: The Involvement Of Central Auditory Pathways In Tinnitusmentioning

confidence: 87%

“…Electrodes can be placed anywhere on the cortex, e.g., motor cortex (Nguyen et al, 1997), somatosensory cortex (De Ridder et al, 2007b), auditory cortex (De Ridder et al, 2007a), or dorsolateral prefrontal cortex (De Ridder et al, 2011d). The target is usually retrieved by functional imaging such as fMRI (De Ridder et al, 2004) or PET scan, but can also be done using a combination of intraoperative electrophysiological measures (ERP; Pirotte et al, 2005) and functional imaging data (MRI; Pirotte et al, 2008).…”

Section: Brain Stimulation Techniquesmentioning

confidence: 99%

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Neuroimaging and Neuromodulation: Complementary Approaches for Identifying the Neuronal Correlates of Tinnitus

Langguth

Schecklmann

Lehner

et al. 2012

Front. Syst. Neurosci.

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An inherent limitation of functional imaging studies is their correlational approach. More information about critical contributions of specific brain regions can be gained by focal transient perturbation of neural activity in specific regions with non-invasive focal brain stimulation methods. Functional imaging studies have revealed that tinnitus is related to alterations in neuronal activity of central auditory pathways. Modulation of neuronal activity in auditory cortical areas by repetitive transcranial magnetic stimulation (rTMS) can reduce tinnitus loudness and, if applied repeatedly, exerts therapeutic effects, confirming the relevance of auditory cortex activation for tinnitus generation and persistence. Measurements of oscillatory brain activity before and after rTMS demonstrate that the same stimulation protocol has different effects on brain activity in different patients, presumably related to interindividual differences in baseline activity in the clinically heterogeneous study cohort. In addition to alterations in auditory pathways, imaging techniques also indicate the involvement of non-auditory brain areas, such as the fronto-parietal “awareness” network and the non-tinnitus-specific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdale. Involvement of the hippocampus and the parahippocampal region putatively reflects the relevance of memory mechanisms in the persistence of the phantom percept and the associated distress. Preliminary studies targeting the dorsolateral prefrontal cortex, the dorsal anterior cingulate cortex, and the parietal cortex with rTMS and with transcranial direct current stimulation confirm the relevance of the mentioned non-auditory networks. Available data indicate the important value added by brain stimulation as a complementary approach to neuroimaging for identifying the neuronal correlates of the various clinical aspects of tinnitus.

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“…Also wire electrodes have been inserted in the primary auditory cortex, with comparable results (De Ridder et al, 2007a; Seidman et al, 2008). …”

Section: The Involvement Of Central Auditory Pathways In Tinnitusmentioning

confidence: 87%

Section: Brain Stimulation Techniquesmentioning

confidence: 99%

Neuroimaging and Neuromodulation: Complementary Approaches for Identifying the Neuronal Correlates of Tinnitus

Langguth

Schecklmann

Lehner

et al. 2012

Front. Syst. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Another potential explanation may be that rTMS interferes with tinnitus by modulating inhibitory function in the thalamus (Langguth et al 2007b;May et al 2007) and that the exact cortical area does not matter as long as auditory corticothalamic loops are reached. It is also possible that rTMS exerts its activity on the primary auditory cortex (Lorenz et al 2010) via stimulation of the more superfi cial secondary auditory cortex, as suggested by fi ndings from epidural stimulation (De Ridder et al 2007). Direct comparison of the stimulated area and treatment effects on an individual level could help to clarify whether treatment response depends on exact coil positioning and what would be the optimal target .…”

Section: Statement Of Interestmentioning

confidence: 99%