Auditory brainstem response to speech in children with high functional autism spectrum disorder

Ramezani, Maryam; Lotfi, Yones; Moossavi, Abdollah; Bakhshi, Enayatollah

doi:10.1007/s10072-018-3594-9

Cited by 23 publications

(18 citation statements)

References 26 publications

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“…The ABR has provided the most insight into the function of brainstem centers in ASD. The majority of studies of the ABR in subjects with ASD over the past 40 years provide evidence that subjects with ASD have smaller amplitudes in waves I, II, III, IV, and V (Ornitz et al, 1972 ; Gillberg et al, 1983 ; Martineau et al, 1987 , 1992 ; Klin, 1993 ), longer latencies between waves I-III and waves I-V (Taylor et al, 1982 ), and longer latencies/slower responses (Ornitz, 1969 ; Student and Sohmer, 1978 ; Rosenblum et al, 1980 ; Sohmer, 1982 ; Tanguay et al, 1982 ; Gillberg et al, 1983 ; Sersen et al, 1990 ; Thivierge et al, 1990 ; Wong and Wong, 1991 ; Maziade et al, 2000 ; Kwon et al, 2007 ; Roth et al, 2012 ; Azouz et al, 2014 ; Taş et al, 2017 ; Miron et al, 2018 , 2021 ; Ramezani et al, 2019 ; Delgado et al, 2021 ; reviewed in Talge et al, 2018 ). These longer latency and lower amplitude responses have been attributed to the immaturity of brainstem circuits (Li et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behaviors, poor social skills, and difficulties with communication. Beyond these core signs and symptoms, the majority of subjects with ASD have some degree of auditory and vestibular dysfunction. Dysfunction in these sensory modalities is significant as normal cognitive development depends on an accurate representation of our environment. The hearing difficulties in ASD range from deafness to hypersensitivity and subjects with ASD have abnormal sound-evoked brainstem reflexes and brainstem auditory evoked potentials. Vestibular dysfunction in ASD includes postural instability, gait dysfunction, and impaired gaze. Untreated vestibular dysfunction in children can lead to delayed milestones such as sitting and walking and poor motor coordination later in life. Histopathological studies have revealed that subjects with ASD have significantly fewer neurons in the auditory hindbrain and surviving neurons are smaller and dysmorphic. These findings are consistent with auditory dysfunction. Further, the cerebellum was one of the first brain structures implicated in ASD and studies have revealed loss of Purkinje cells and the presence of ectopic neurons. Together, these studies suggest that normal auditory and vestibular function play major roles in the development of language and social abilities, and dysfunction in these systems may contribute to the core symptoms of ASD. Further, auditory and vestibular dysfunction in children may be overlooked or attributed to other neurodevelopmental disorders. Herein we review the literature on auditory and vestibular dysfunction in ASD. Based on these results we developed a brainstem model of central auditory and vestibular dysfunction in ASD and propose that simple, non-invasive but quantitative testing of hearing and vestibular function be added to newborn screening protocols.

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Section: Introductionmentioning

confidence: 99%

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Mansour

Burchell

Kulesza

2021

Front. Integr. Neurosci.

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“…Whereas, another study found longer wave V for school aged ASD children (Kamita et al, 2020 ). A study concluded that latencies of all speech-evoked ABR waves and V-A complex duration are longer in the ASD group compared to healthy controls (Ramezani et al, 2019 ). Other studies found differences in specific waves such as latencies in waves C, D, E, F (El Shennawy et al, 2014 ), and wave O (El Shennawy et al, 2014 ; Jones et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder

Seif

Shea

Schmid

et al. 2021

Front. Integr. Neurosci.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects one in 66 children in Canada. The contributions of changes in the cortex and cerebellum to autism have been studied for decades. However, our understanding of brainstem contributions has only started to emerge more recently. Disruptions of sensory processing, startle response, sensory filtering, sensorimotor gating, multisensory integration and sleep are all features of ASD and are processes in which the brainstem is involved. In addition, preliminary research into brainstem contribution emphasizes the importance of the developmental timeline rather than just the mature brainstem. Therefore, the purpose of this systematic review is to compile histological, behavioral, neuroimaging, and electrophysiological evidence from human and animal studies about brainstem contributions and their functional implications in autism. Moreover, due to the developmental nature of autism, the review pays attention to the atypical brainstem development and compares findings based on age. Overall, there is evidence of an important role of brainstem disruptions in ASD, but there is still the need to examine the brainstem across the life span, from infancy to adulthood which could lead the way for early diagnosis and possibly treatment of ASD.

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“…The FFR is sensitive to changes in human communication involving hearing, language, and learning. For more than 2 decades, studies have shown that FFR is able to reveal different aspects of communication impairment, such as auditory processing deficits (Filippini et al, 2012;Graydon et al, 2019;Johnson et al, 2005;Koravand et al, 2019;Krishnamurti et al, 2013;Lotfi et al, 2019), phonological disorders (Bonacina et al, 2019;Ferreira et al, 2019), learning difficulties (Banai et al, 2009;Malayeri et al, 2014), dyslexia (Basu et al, 2010;Hornickel & Kraus, 2013), and a Speech, Language and Hearing Sciences Graduate Program, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil even autism (Chen et al, 2019;Font-Alaminos et al, 2020;Ramezani et al, 2018). The FFR proves to be very versatile, and its application goes beyond assessment related to hearing only, as it provides rich information about the neural encoding of speech.…”

mentioning

confidence: 99%

Frequency-Following Response in Newborns and Infants: A Systematic Review of Acquisition Parameters

Lemos

Nunes

Evangelista

et al. 2021

J Speech Lang Hear Res

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Purpose The purpose of this study is to characterize parameters used for frequency-following response (FFR) acquisition in children up to 24 months of age through a systematic review. Method The study was registered in PROSPERO and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses' recommendations. Search was performed in six databases (LILACS, LIVIVO, PsycINFO, PubMed, Scopus, and Web of Science) and gray literature (Google Scholar, OpenGrey, ProQuest)as well as via manual searches in bibliographic references. Observational studies using speech stimuli to elicit the FFR in infants with normal hearing on the age range from 0 until 24 months were included. No restrictions regarding language and year of publication were applied. Risk of bias was assessed with the Joanna Briggs Institute Critical Appraisal Checklist. Data on stimulus, presentation rate, time window for analysis, number of sweeps, artifact rejection, online filters, stimulated ear, and examination condition were extracted. Results Four hundred fifty-nine studies were identified. After removing duplicates and reading titles and abstracts, 15 articles were included. Seven studies were classified as low risk of bias, seven as moderate risk, and one as high risk. Conclusions There is a consensus in the use of some acquisition parameters of the FFR with speech stimulus, such as the vertical mounting, the use of alternating polarity, a sampling rate of 20000 Hz, and the /da/ synthesized syllable of 40 ms in duration as the preferred stimulus. Although these parameters show some consensus, the results disclosed lack of a single established protocol for FFR acquisition with speech stimulus in infants in the investigated age range.

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Auditory brainstem response to speech in children with high functional autism spectrum disorder

Cited by 23 publications

References 26 publications

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder

A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder

Frequency-Following Response in Newborns and Infants: A Systematic Review of Acquisition Parameters

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