Auditory attention in early Parkinson's disease: An impairment in focused attention

Sharpe, Margaret H.

doi:10.1016/0028-3932(92)90019-i

Cited by 61 publications

(37 citation statements)

References 37 publications

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“…On the one hand, the possibility of a cognitive resource dedicated to sentence processing has emerged from a series of negative correlations between sentence comprehension difficulty and nonsyntactic measures of executive functioning (Grossman et al, 1992). On the other hand, PD patients have demonstrated parallel impairments on verbal and nonverbal measures of executive function and selective attention (Sharpe, 1992;Maddox et al, 1996;Taylor et al, 1986;Brown & Marsden, 1988, 1991. These findings would be most consistent with a material-neutral, general-purpose disorder of executive functioning.…”

Section: Introductionmentioning

confidence: 77%

“…However, this was not found. Many studies have shown that PD patients are impaired on nonlinguistic tasks that challenge cognitive resources with dual task measures, selective attention, and the development of internally generated cognitive strategies for atypically ordered arrays of information (Brown & Marsden, 1988, 1991Sharpe, 1992;Maddox et al, 1996;Taylor et al, 1986). In this context, our observations can be interpreted to support the claim that a material-neutral, general-purpose cognitive resource is compromised in these PD patients.…”

Section: Figmentioning

confidence: 96%

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Cognitive Resource Limitations during Sentence Comprehension in Parkinson's Disease

et al. 2000

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Section: Introductionmentioning

confidence: 77%

Section: Figmentioning

confidence: 96%

Cognitive Resource Limitations during Sentence Comprehension in Parkinson's Disease

et al. 2000

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“…In addition, PD patients present difficulties in shifting from one cognitive set to another at the WCST (Lees & Smith, 1983;Bowen et al, 1975), and likewise, they are unable to maintain a set against competing alternatives at the odd-man-out choice discrimination task (Flowers & Robertson, 1985). Finally, they are more prone to interference in the presence of a distractor stimulus compared with normal controls, as measured on a dichotic listening task (Sharpe, 1992). Moreover, several behavioral studies indicate that parkinsonian patients with overall well-preserved cognitive functions may nevertheless be impaired at a variety of visual attention tasks (Filoteo et al, 1995;Wright, Burns, Geffen, & Geffen, 1990;Yamada, Izyuuinn, Schulzer, & Hirayama, 1990) and more specifically at tasks tapping selective attention mechanisms (Cools, Rogers, Barker, & Robbins, 2009;Henik, Singh, Beckley, & Rafal, 1993;Pillon et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Disentangling the Role of Cortico-Basal Ganglia Loops in Top–Down and Bottom–Up Visual Attention: An Investigation of Attention Deficits in Parkinson Disease

Tommasi

Fiorio

Yelnik

et al. 2015

Journal of Cognitive Neuroscience

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Abstract■ It is solidly established that top-down (goal-driven) and bottom-up (stimulus-driven) attention mechanisms depend on distributed cortical networks, including prefrontal and frontoparietal regions. On the other hand, it is less clear whether the BG also contribute to one or the other of these mechanisms, or to both. The current study was principally undertaken to clarify this issue. Parkinson disease (PD), a neurodegenerative disorder primarily affecting the BG, has proven to be an effective model for investigating the contribution of the BG to different brain functions; therefore, we set out to investigate deficits of top-down and bottom-up attention in a selected cohort of PD patients. With this objective in mind, we compared the performance on three computerized tasks of two groups of 12 parkinsonian patients (assessed without any treatment), one otherwise pharmacologically treated and the other also surgically treated, with that of a group of controls. The main behavioral tool for our study was an attentional capture task, which enabled us to tap the competition between top-down and bottom-up mechanisms of visual attention. This task was suitably combined with a choice RT and a simple RT task to isolate any specific deficit of attention from deficits in motor response selection and initiation. In the two groups of patients, we found an equivalent increase of attentional capture but also comparable delays in target selection in the absence of any salient distractor (reflecting impaired top-down mechanisms) and movement initiation compared with controls. In contrast, motor response selection processes appeared to be prolonged only in the operated patients. Our results confirm that the BG are involved in both motor and cognitive domains. Specifically, damage to the BG, as it occurs in PD, leads to a distinct deficit of top-down control of visual attention, and this can account, albeit indirectly, for the enhancement of attentional capture, reflecting weakened ability of top-down mechanisms to antagonize bottom-up control. ■

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“…Nondemented Parkinson's disease patients display a number of neuropsychological deficits that are present at all stages of the disease (Lees and Smith, 1983;Boller et al, 1984;Taylor et al, 1986;Brown and Marsden, 1988). These deficits are mostly "frontal-like" in nature and consist of problems of attention (Flowers and Robertson, 1985;Downes et al, 1989;Sharpe, 1990Sharpe, , 1992 and "executive functions" (e.g., planning and cognitive flexibility) (Cooper et al, 1991;Owen et al, 1992). Other cognitive functions, such as working memory, have been found to be relatively unimpaired in Parkinson's disease patients (Freedman and Oscar-Berman, 1986;Taylor et al, 1986) but when present may be related to attentional processes involved in taskrelated learning strategies (Pillon et al, 1998;Nieoullon, 2002) .…”

mentioning

confidence: 99%

The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys

Schneider

Tinker²,

Menzaghi³

et al. 2003

J Pharmacol Exp Ther

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Monkeys that receive chronic low dose (CLD) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration develop deficits in spatial delayed-response task performance. The present study examined the extent to which SIB-1553A [(Ϯ)-4-{[2-(1-methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride], a novel neuronal nicotinic acetylcholine receptor (nAChR) agonist with selectivity for ␤4 subunit-containing nAChRs, could counteract this cognitive deficit produced by CLD MPTP exposure. Prior to MPTP treatment, monkeys displayed a delay-dependent decrement in performance on a variable delayed response task. CLD MPTP treatment caused a shift to a delay-independent pattern of responding on this task, such that short-delay trials were performed as poorly as long-delay trials. At lower doses (e.g., 0.025 mg/kg), SIB-1553A significantly improved performance on short-delay trials but only at 24 h after drug administration. At higher doses (e.g., 0.50 mg/kg), SIB-1553A significantly improved performance on both short-and longdelay trials at both 20 min and 24 h after drug administration. When tested 24 h after drug administration, monkeys performed long-delay trials with greater accuracy than they did under normal (pre-MPTP) conditions. These results suggest that at lower doses, SIB-1553A may be more effective in improving attentional deficits associated with CLD MPTP exposure, whereas at higher doses, SIB-1553A may effectively improve both attentional and memory performance.

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Auditory attention in early Parkinson's disease: An impairment in focused attention

Cited by 61 publications

References 37 publications

Cognitive Resource Limitations during Sentence Comprehension in Parkinson's Disease

Cognitive Resource Limitations during Sentence Comprehension in Parkinson's Disease

Disentangling the Role of Cortico-Basal Ganglia Loops in Top–Down and Bottom–Up Visual Attention: An Investigation of Attention Deficits in Parkinson Disease

The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys

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