Audiological assessment of neonatal hyperbilirubinemia

Mandour, Yasser; Sayed, Mohamed A. El; Morgan, Ashraf Elsayed; Bassam, Rehab; Fadl, Hamada; Elrefae, Ahmed

doi:10.1016/j.ijporl.2020.110126

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…11 The aetiology of and the effective prevention strategies for hyperbilirubinaemia have been described in clinical guidelines. 12 There has been extensive research and progress on the main causes of neonatal hyperbilirubinaemia. 13 Compared with another study, 14 this current study used INR to evaluate the correlation between hyperbilirubinaemia and coagulation.…”

Section: Discussionmentioning

confidence: 99%

Coagulation profile of neonates with hyperbilirubinaemia in full-term newborns

Zhou,

Huang,

Zhang

2023

J Int Med Res

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Objective: To determine the relationship between coagulation system markers and hyperbilirubinaemia in full-term neonates. Methods: This retrospective case–control study enrolled full-term neonates with hyperbilirubinaemia and healthy control full-term neonates. Prothrombin time (PT), thrombin time (TT), fibrinogen (Fbg), activated partial thromboplastin time (APTT) and international normalized ratio (INR) were recorded. The correlation between INR and total bilirubin and between INR and indirect bilirubin was analysed by linear regression analysis. Receiver operating characteristic curve analysis was used to assess the efficacy of INR to identify neonates with hyperbilirubinaemia. Results: This study enrolled 40 full-term neonates with hyperbilirubinaemia and 30 healthy controls. PT, INR and APTT were significantly higher in the neonates with hyperbilirubinaemia compared with the healthy controls. There was a significant positive correlation between INR and the level of total bilirubin in neonates with hyperbilirubinaemia ( R = 0.3327). There was also a significant positive correlation between INR and the level of indirect bilirubin in neonates with hyperbilirubinaemia ( R = 0.3406). INR in neonates with hyperbilirubinaemia significantly achieved an area under the curve of 0.800 (95% confidence interval, 0.6288, 0.9712; cut-off value, 1.060; specificity, 71.43%; sensitivity, 80.00%). Conclusion: These findings suggest that INR is a novel biomarker for the diagnosis of neonatal hyperbilirubinaemia in full-term neonates.

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Section: Discussionmentioning

confidence: 99%

Coagulation profile of neonates with hyperbilirubinaemia in full-term newborns

Zhou,

Huang,

Zhang

2023

J Int Med Res

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“…Hyperbilirubinemia often occurred in infants without apparent reason [11]. The causes of hyperbilirubinemia and effective prevention strategies have recommended as clinical guidelines [12]. The American Academic of Pediatrics(APP) recommends a follow-up visit after 48-72 h of the newborns discharged [13].…”

Section: Discussionmentioning

confidence: 99%

The Coagulation Analysis of Reveals Novel Biomarkers for Neonatal Hyperbilirubinemia in Full Term Newborn

Zhou

Liu

2021

Preprint

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Background: The coagulation test is used to evaluate in various diseases. Little is known about correlation between the coagulation test and neonatal hyperbilirubinemia. The aim of the study was to determine the neonatal coagulation analysis value in infants with neonatal hyperbilirubinemia as reliable markers. Methods: All newborns were born and inpatients in the newborn wards of the Chengdu Second People’s Hospital. Measurement of serum bilirubin was done to diagnose hyperbilirubinemia. All neonates involved were full term of either gender without any significant illness or major congenital malformations. Data were collected from newborns who had neonatal hyperbilirubinemia and healthy in Chengdu Second People’s Hospital. Prothrombin time(PT), Thrombin time(TT), Fibrinogen(Fbg), activated partial thromboplastin time(APTT), and calculated international normalized ration(INR) values were recorded. Linear relationship between INR and level of total bilirubin and indirect bilirubin were analyzed by linear regression. The receiver operating curve(ROC) and the area under the curve(AUC) were made evaluated. Results: In this case-control study, the mean PT, APTT level were significant higher in the infants with hyperbilirubinemia group compared to the healthy infants. We found the positive correlation between INR and total bilirubin(R=0.3327; P<0.0001). Furthermore, there was also significant positive correlation between INR and indirect bilirubin(R=0.3402; P<0.0001). Meanwhile, INR in neonates with hyperbilirubinemia significantly achieved an AUC of 0.800(95% CI=0.6288-0.9712, cutoff value 1.060, specificity71.43%, and sensitivity 80.00%).Conclusions: PT, APTT were significant high in neonatal hyperbilirubinemia group. Correlation were observed between the INR and neonatal hyperbilirubinemia. Importantly, the study revealed INR as novel biomarkers for diagnosis of neonatal hyperbilirubinemia in full term newborn.

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“…Pewarnaan kuning pada sklera, kulit dan membran mukosa merupakan gejala klinis yang umum terjadi. 2 Terdapat dua jenis hiperbilirubinemia yaitu hiperbilirubinemia indirek atau tidak terkonjugasi dan hiperbilirubinemia direk atau terkonjugasi. 3 Bayi baru lahir dapat diperiksa kadar bilirubin sebelum dipulangkan dari rumah sakit.…”

Section: Pendahuluanunclassified

Mekanisme Terjadinya Hiperbilirubinemia pada Bayi Berat Lahir Rendah

Gerungan

Wilar

Mantik

2022

eCL

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Hyperbilirubinemia is frequently found in newborns, especially in low birth weight (LBW) infants (less than 2,500 g). Hyperbilirubinemia is an increase in bilirubin higher than 5 mg/dL which clinically manifests as icterus. This study aimed to evaluate the relationship between LBW and the incidence of hyperbilirubinemia as well as the underlying mechanism. This was a literature study. Article searching used databases of Pubmed and Google Schoolar and the keywords were Hyperbilirubinemia AND Low birth weight NAD Neonatal Jaundice. The results showed a relationship between LBW and the incidence of hyperbilirubinemia. There were increases of hemoglobin, heme catabolism, and destruction of bilirubin due to liver immaturity, impaired liver function and perfusion and bilirubin conjugation ability, less of albumin as the transportation protein and uridine diphosphate glucuronyltransferase (UDP-GT) to convert indirect bilirubin to direct bilirubin in the liver. In conclusion, there is a relationship between low birth weight and hyperbilirubinemia that occurs due to liver immaturity, impaired liver function and perfusion, and less of albumin and UDP-GT enzyme.Keywords: hyperbilirubinemia; low birth weight; neonatal jaundice Abstrak: Hiperbilirubinemia merupakan masalah yang sering terjadi pada bayi baru lahir terlebih bayi dengan berat lahir rendah (<2.500 gram). Hiperbilirubinemia merupakan peningkatan kadar bilirubin serum >5mg/dL yang bermanifestasi klinis berupa ikterus. Penelitian ini bertujuan untuk mengetahui hubungan antara BBLR dengan kejadian hiperbilirubinemia dan mekanisme terjadinya. Jenis penelitian ialah suatu literature review. Pencarian artikel menggunakan Pubmed dan Google Schoolar dengan kata kunci Hyperbilirubinemia AND Low birth weight AND Neonatal Jaundice. Hasil penelitian mendapatkan adanya hubungan antara BBLR dengan kejadian hiperbilirubinemia. Terdapat peningkatan jumlah hemoglobin, katabolisme heme dan penghan-curan bilirubin yang terjadi antara lain karena imaturitas hati yang belum optimal mengkonju-gasikan bilirubin, terganggunya fungsi dan perfusi hati serta kemampuan mengkonjugasi bilirubin, rendahnya kadar protein albumin sebagai transportasi dan enzim uridin difosfat glukoronid transferase (UDP-GT) untuk mengonversi bilirubin indirek menjadi bilirubin direk di dalam hati. Simpulan penelitian ini ialah terdapat hubungan antara BBLR dengan hiperbilirubinemia yang dapat terjadi karena imaturitas hati, terganggunya fungsi dan perfusi hati, serta kurangnya protein albumin dan enzim UDP-GT.Kata kunci: hiperbilirubinemia; low birth weight; neonatal jaundice

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Audiological assessment of neonatal hyperbilirubinemia

Cited by 5 publications

References 5 publications

Coagulation profile of neonates with hyperbilirubinaemia in full-term newborns

Coagulation profile of neonates with hyperbilirubinaemia in full-term newborns

The Coagulation Analysis of Reveals Novel Biomarkers for Neonatal Hyperbilirubinemia in Full Term Newborn

Mekanisme Terjadinya Hiperbilirubinemia pada Bayi Berat Lahir Rendah

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