Au@p4VP core@shell pH-sensitive nanocomposites suitable for drug entrapment

Clara-Rahola, Joaquim; Moscoso, Ana; Ruiz-Muelle, Ana Belén; Laurenti, Marco; López‐Romero, Juan Manuel; Fernández, Ignacio; Díaz, J. Fernando; Rubio-Retama, Jorge; Fery, Andreas; Contreras‐Cáceres, Rafael

doi:10.1016/j.jcis.2017.12.072

Cited by 22 publications

(13 citation statements)

References 56 publications

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“…In contrast, the homopolymer CC01 showed variable swelling capacities due to the basic nature of the pyridine nitrogen ring [34]. The critical pH value determined was found to be 4.9, which was very similar to that reported by Clara-Rahola et al [35]. This homopolymer presented a significant swelling capacity, because, at these values, the pyridine groups of p(4VP) are protonated; thus, the repulsive electrostatic contribution induces the swelling of the polymer structure forming hydrogen bonds with the water molecules in the medium.…”

Section: Resultssupporting

confidence: 72%

Synthesis and Characterization of Clay Polymer Nanocomposites of P(4VP-co-AAm) and Their Application for the Removal of Atrazine

et al. 2019

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Atrazine (ATZ) is an herbicide which is applied to the soil, and its mechanism of action involves the inhibition of photosynthesis. One of its main functions is to control the appearance of weeds in crops, primarily in corn, sorghum, sugar cane, and wheat; however, it is very toxic for numerous species, including humans. Therefore, this work deals with the adsorption of ATZ from aqueous solutions using nanocomposite materials, synthesized with two different types of organo-modified clays. Those were obtained by the free radical polymerization of 4-vinylpyridine (4VP) and acrylamide (AAm) in different stoichiometric ratios, using tetrabutylphosphonium persulfate (TBPPS) as a radical initiator and N,N′-methylenebisacrylamide (BIS) as cross-linking agent. The structural, morphological, and textural characteristics of clays, copolymers, and nanocomposites were determined through different analytical and instrumental techniques, i.e., X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Adsorption kinetics experiments of ATZ were determined with the modified and synthesized materials, and the effect of the ratio between 4VP and AAm moieties on the removal capacities of the obtained nanocomposites was evaluated. Finally, from these sets of experiments, it was demonstrated that the synthesized nanocomposites with higher molar fractions of 4VP obtained the highest removal percentages of ATZ.

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Section: Resultssupporting

confidence: 72%

Synthesis and Characterization of Clay Polymer Nanocomposites of P(4VP-co-AAm) and Their Application for the Removal of Atrazine

et al. 2019

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“…Second, at pH above 7, It is quite likely that DOX is attached to doxy-AuNPs via H-bond interaction. The N , N -dimethyl amino group of doxycycline may involve in making H-bonding with the hydroxyl group of DOX present at a proximal position of the amino group on the side ring. , To provide some level of understanding, morphological changes of DOX-loaded doxy-AuNPs were examined by TEM. DOX molecules showed tendency to give rise to a more complex network of doxy-AuNPs after loading on the surface of doxy-AuNPs (Figure c).…”

Section: Resultsmentioning

confidence: 99%

In Vitro Drug Release and Biocatalysis from pH-Responsive Gold Nanoparticles Synthesized Using Doxycycline

et al. 2019

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pH-sensitive doxycycline gold nanoparticles (doxy-AuNPs) are reported here to act as effective drug nanocarriers and as biocatalysts. The AuNPs were synthesized with doxy as the reducing and capping agent. Various parameters were optimized to find the best conditions for the synthesis of doxy-AuNPs, and these were characterized with UV−vis, X-ray diffraction (XRD), FTIR, and transmission electron microscopy (TEM). Doxy-AuNPs were then loaded with the anticancer drug doxorubicin (DOX), where 70% of the initially available drug was loaded within 24 h. Furthermore, pH-dependent drug release was measured at 60% with in vitro measurements in phosphate-buffered saline (PBS). In addition, the doxy-AuNPs were applied as a biocatalyst. Oxidation of dopamine was taken as a model reaction to determine the catalytic activity of doxy-AuNPs. Almost complete oxidation of dopamine occurred in 5 min, which indicates the fast response of synthesized doxy-AuNPs as a biocatalyst. Hence, doxy-AuNPs are a versatile platform for drug loading and biocatalyst.

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“…Two of the more investigated hydrogels in colloidal chemistry are made of poly( N -isopropylacrylamide) (pNIPAM) and poly(4-vinylpyridine) (p4VP). − These nanoparticles possess thermo- and pH-responsive capabilities, respectively. The former has the volume phase transition temperature at about 32 °C, and the latter has the phase transition at pH 4.8.…”

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confidence: 99%

Scaling Laws in the Diffusive Release of Neutral Cargo from Hollow Hydrogel Nanoparticles: Paclitaxel-Loaded Poly(4-vinylpyridine)

et al. 2020

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We study the nonequilibrium diffusive release of electroneutral molecular cargo encapsulated inside hollow hydrogel nanoparticles. We propose a theoretical model that includes osmotic, steric, and short-range polymer−cargo attractions to determine the effective cargo−hydrogel interaction, u eff *, and the effective diffusion coefficient of the cargo inside the polymer network, D eff *. Using dynamical density functional theory (DDFT), we investigate the scaling of the characteristic release time, τ 1/2 , with the key parameters involved in the process, namely, u eff *, D eff *, and the swelling ratio. This effort represents a full study of the problem, covering a broad range of cargo sizes and providing predictions for repulsive and attractive polymer shells. Our calculations show that the release time through repulsive polymer networks scales with q 2 e βu eff * /D eff * for βu eff * ≫ 1. In this case, the cargo molecules are excluded from the shell of the hydrogel. For attractive shells, the polymer retains the cargo molecules on its internal surface and its interior, and the release time grows exponentially with the attraction strength. The DDFT calculations are compared to an analytical model for the mean first passage time, which provides an excellent quantitative description of the kinetics for both repulsive and attractive shells without fitting parameters. Finally, we apply the method to reproduce experimental results on the release of paclitaxel from hollow poly(4-vinylpyridine) nanoparticles and find that the slow release of the drug can be explained in terms of the strong binding attraction between the drug and the polymer.

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Au@p4VP core@shell pH-sensitive nanocomposites suitable for drug entrapment

Cited by 22 publications

References 56 publications

Synthesis and Characterization of Clay Polymer Nanocomposites of P(4VP-co-AAm) and Their Application for the Removal of Atrazine

Synthesis and Characterization of Clay Polymer Nanocomposites of P(4VP-co-AAm) and Their Application for the Removal of Atrazine

In Vitro Drug Release and Biocatalysis from pH-Responsive Gold Nanoparticles Synthesized Using Doxycycline

Scaling Laws in the Diffusive Release of Neutral Cargo from Hollow Hydrogel Nanoparticles: Paclitaxel-Loaded Poly(4-vinylpyridine)

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