Au-NPs enhanced SPR biosensor based on hairpin DNA without the effect of nonspecific adsorption

Luan, Qingfen; Zhou, Kebin; Tan, Haina; Yang, Dan; Yao, Xin

doi:10.1016/j.bios.2010.10.035

Cited by 26 publications

(8 citation statements)

References 42 publications

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“…Restriction endonucleases are important enzymes for genotyping, mapping and recombinant DNA technology 78,79 . Recently, Luan et al 80 reported a novel Au NPs-amplified SPR strategy for sensing of RsaI endonuclease (5 x 10 −8 M) without the effect from nonspecific adsorption. RsaI endonuclease is known for specifically recognizing the GTAC sequence and cleaving between the T and A.…”

Section: Sensing Of Dna and Oligonucleotidesmentioning

confidence: 99%

Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications

Zeng

Baillargeat²,

et al. 2014

Chem. Soc. Rev.

1,062

563

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The main challenge for all electrical, mechanical and optical sensors is to detect low molecular weight (less than 400 Da) chemical and biological analytes under extremely dilute conditions. Surface plasmon resonance sensors are the most commonly used optical sensors due to their unique ability for real-time monitoring the molecular binding events. However, their sensitivities are insufficient to detect trace amounts of small molecular weight molecules such as cancer biomarkers, hormones, antibiotics, insecticides, and explosive materials which are respectively important for early-stage disease diagnosis, food quality control, environmental monitoring, and homeland security protection. With the rapid development of nanotechnology in the past few years, nanomaterials-enhanced surface plasmon resonance sensors have been developed and used as effective tools to sense hard-to-detect molecules within the concentration range between pmol and amol. In this review article, we reviewed and discussed the latest trend and challenges in engineering and applications of nanomaterials-enhanced surface plasmon resonance sensors (e.g., metallic nanoparticles, magnetic nanoparticles, carbon-based nanomaterials, latex nanoparticles and liposome nanoparticles) for detecting "hard-to-identify" biological and chemical analytes. Such information will be viable in terms of providing a useful platform for designing future ultrasensitive plasmonic nanosensors.

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Section: Sensing Of Dna and Oligonucleotidesmentioning

confidence: 99%

Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications

Zeng

Baillargeat²,

et al. 2014

Chem. Soc. Rev.

1,062

563

View full text Add to dashboard Cite

show abstract

“…One reason is that the assembling requires continuing. The other reason is the limited phosphate backbone stress and steric hindrance inhibiting the unrestricted assembling of DNA, and the superabundant DNA causes the unspecific adsorption or dispersion [22].…”

Section: Dna Assembling Controlmentioning

confidence: 99%

DNA cyclic assembling control in an electrochemical strategy with MoS2@AuNPs for determination of kanamycin

Wang

Zhang

et al. 2021

Microchim Acta

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A sensitive electrochemical strategy was established for kanamycin determination. A specific aptamer was modified on the electrode as the probe, followed by a cyclic hybridization chain reaction (HCR) with methylene blue, causing an increasing signal response. In the presence of kanamycin, it can initiatively convolve the aptamer and prevent further DNA assembling, resulting in a signal distinction sensitive to the target amount. However, the signal reproducibility is low. To improve the precision, the HCR procedure was investigated. The results demonstrated that the optimal amount of assembled DNA is 12-fold to that of aptamer. This amount was then controlled in further assays. Admittedly, controlled DNA assembling commonly indicates a limited signal amplification. To further enhance the sensitivity, a nanocomposite based on MoS 2 and AuNPs was modified on the electrode. The results of the assay proved that the signal distinction sensitive to target amount increased by 50%. A linearity range is obtained from 0.01 nM to 1.0 μM of kanamycin, and the LOD is 8.4 pM. Subsequently, this strategy was employed to detect kanamycin in chicken liver and milk sample; the recovery results suggest that it possess a satisfactory application prospect in analysis of agricultural products.

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“…35 These hairpin DNA fragments are of particular interest in biosensing as they can be functionalized by different elements such as gold nanoparticles, a dye or a molecular probe. [36][37][38][39] Intrinsically, emerging rhodamine B nanocrystals are highly fluorescent (Fig. 4a).…”

Section: Sensing Platform Evaluation: Hairpin-shaped Dnamentioning

confidence: 99%

Fluorescent molecular nanocrystals anchored in sol–gel thin films: a label-free signalization function for biosensing applications

Dubuisson

Szunerits²,

Bacia

et al. 2011

New J. Chem.

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Au-NPs enhanced SPR biosensor based on hairpin DNA without the effect of nonspecific adsorption

Cited by 26 publications

References 42 publications

Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications

Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications

DNA cyclic assembling control in an electrochemical strategy with MoS2@AuNPs for determination of kanamycin

Fluorescent molecular nanocrystals anchored in sol–gel thin films: a label-free signalization function for biosensing applications

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