Au nanoparticle/graphene nanocomposite as a platform for the sensitive detection of NADH in human urine

Maduraiveeran, Govindhan; Amiri, Mona; Chen, Aicheng

doi:10.1016/j.bios.2014.12.012

Cited by 150 publications

(59 citation statements)

References 53 publications

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“…Govindhan et al demonstrated an Au/rGO electrode to detect NADH via CV. Compared to previous works, the Au/rGO sensor had an almost 100 times higher sensitivity and extremely low detecting limit 128. H 2 O 2 generates in various enzymatic reactions.…”

Section: The Human‐like Senses and Feedbacksmentioning

confidence: 85%

Human‐Like Sensing and Reflexes of Graphene‐Based Films

et al. 2016

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Humans have numerous senses, wherein vision, hearing, smell, taste, and touch are considered as the five conventionally acknowledged senses. Triggered by light, sound, or other physical stimulations, the sensory organs of human body are excited, leading to the transformation of the afferent energy into neural activity. Also converting other signals into electronical signals, graphene‐based film shows its inherent advantages in responding to the tiny stimulations. In this review, the human‐like senses and reflexes of graphene‐based films are presented. The review starts with the brief discussions about the preparation and optimization of graphene‐based film, as where as its new progress in synthesis method, transfer operation, film‐formation technologies and optimization techniques. Various human‐like senses of graphene‐based film and their recent advancements are then summarized, including light‐sensitive devices, acoustic devices, gas sensors, biomolecules and wearable devices. Similar to the reflex action of humans, graphene‐based film also exhibits reflex when under thermal radiation and light actuation. Finally, the current challenges associated with human‐like applications are discussed to help guide the future research on graphene films. At last, the future opportunities lie in the new applicable human‐like senses and the integration of multiple senses that can raise a revolution in bionic devices.

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Section: The Human‐like Senses and Feedbacksmentioning

confidence: 85%

Human‐Like Sensing and Reflexes of Graphene‐Based Films

et al. 2016

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“…This system is important in pharmaceutical and food industry as well as in biotechnology industry since it is present in drugs, biosensors, but also in biofuel cells and bioreactors [1][2][3][4][5][6][7], nevertheless is expensive and the redox process is usually irreversible [3,6]. In the NAD + reduction, the reversible redox process occurs in nicotinamide ring, which accepts two electrons from a substrate in the presence of an appropriated enzyme, forming NADH: SH 2 + NAD + ⇄ S + NADH+ H + [3].…”

Section: Introductionmentioning

confidence: 99%

A Simple Procedure to Fabricate Paper Biosensor and Its Applicability—NADH/NAD+ Redox System

Ribau¹,

Fortunato²

2018

JPP

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Abstract:A simple device which incorporates three electrodes (working electrode, counter electrode and reference electrode) was constructed to be used currently in laboratories without elevated cost. It does not need more than 2 µL of electrolyte, sample or working solution, his support material is paper, and the working electrode which is based on carbon ink can incorporate enzymes and cofactors. To test this concept we started this investigation using the NADH/NAD + redox couple which is an omnipresent coenzyme in living systems but is also a challenge to electrochemistry. The paper sensor fabrication was simple, rapid and cheaper. NADH was incorporated in the carbon ink by mixing both and, this mixture was used to print the working electrode. The direct electrochemical system NADH/NAD + signal obtained, using this device, appeared at low potentials. A quasi-reversible diffusional redox process was achieved and regeneration of the NADH after oxidation was reached. This small paper device was not only used to study the redox process of NAD + /NADH, but also its behavior in the presence of electroactive (ascorbic acid) and non-eletroactive species (glucose).

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“…For these reasons, electrode materials showing enhanced catalytic activity are very important to attain extremely sensitive detection of glucose. Notably, NiCo 2 O 4 -polyaniline, Ag-CNT, Ni-CNT, graphene-CNT, graphene-polypyrrole, MnO 2 -rGO, NiO-CNT, TiO 2 -MWCNT, CdTe-CdS, graphene-CdS, PtM-CNT, Ni-carbon nanofiber and Pt-polypyrrole have been used as nanohybrid materials in the determination of glucose (Govindhan et al 2015;Baghayeri et al 2016;Yu et al 2016). Recently, nanostructured TiO 2 and Mn 3 O 4 have attracted enormous research interest in the design of electrochemical biosensors owing to their large electroactive surface area, electrocatalytic activity and enhanced electron transfer rate (Hu et al 2011;Reza et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Non-enzymatic detection of glucose in fruits using TiO2–Mn3O4 hybrid nano interface

et al. 2017

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Consumption of fruits leads to increase in glucose level in blood for diabetic patients, which in turn leads to peripheral, vascular, ocular complications and cardiac diseases. In this context, a non-enzymatic hybrid glucose biosensor was fabricated for the first time to detect glucose by immobilizing titanium oxide-manganese oxide (TiO 2 -Mn 3 O 4 ) nanocomposite and chitosan membrane on to the surface of Pt working electrode (Pt/TiO 2 -Mn 3 O 4 /chitosan). TiO 2 -Mn 3 O 4 nanocomposite catalyzed the oxidation of glucose to gluconolactone in the absence of glucose oxidase enzyme with high electron transfer rate, good biocompatibility and large surface coverage. Electrochemical measurements revealed the excellent sensing response of the developed biosensor towards glucose with a high sensitivity of 7.073 lA mM -1 , linearity of 0.01-0.1 mM, low detection limit of 0.01 lM, reproducibility of 1.5% and stability of 98.8%. The electrochemical parameters estimated from the anodic process were subjected to linear regression models for the detection of unknown concentration of glucose in different fruit samples.

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Au nanoparticle/graphene nanocomposite as a platform for the sensitive detection of NADH in human urine

Cited by 150 publications

References 53 publications

Human‐Like Sensing and Reflexes of Graphene‐Based Films

Human‐Like Sensing and Reflexes of Graphene‐Based Films

A Simple Procedure to Fabricate Paper Biosensor and Its Applicability—NADH/NAD+ Redox System

Non-enzymatic detection of glucose in fruits using TiO2–Mn3O4 hybrid nano interface

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